Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
批准号:
9194369
负责人:
Francis Joseph McClernon
金额:
$43.48万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-08-15 至 2019-06-30
关键词:
AbstinenceAcuteAddressAdolescentAdolescent and Young AdultAdultAffectAgeCigaretteCotinineDependenceDizzinessDoseDouble-Blind MethodEvaluationFamily Smoking Prevention and Tobacco Control ActFrequenciesGoalsHealthIndividualLogistic RegressionsMethodsNicotineNicotine DependenceParticipantPatternPlasmaPublic HealthRandomizedReactionRegression AnalysisReportingResearchRiskRoleSamplingSelf-AdministeredSeriesSmokeSmokerSmokingSmoking BehaviorTestingTimeTobaccoTobacco DependenceTobacco smokeTobacco useToxicant exposureauthoritycigarette smokingexperienceimprovedpopulation healthreduce tobacco useresearch studysexyoung adult
中文摘要
2009年通过的《家庭吸烟预防和烟草控制法》为FDA提供了监管
英文摘要
Passage of the Family Smoking Prevention and Tobacco Control Act in 2009 provides the FDA with regulatory
authority to reduce the nicotine content of cigarettes if doing so will result in improved population health.
Accumulating evidence suggests that reducing nicotine content in cigarettes reduces smoking behavior and
toxicant exposure among adult daily, dependent smokers. However, such research leaves open the question
of the effects of nicotine reduction on experimentation with cigarettes among adolescents and young adults at
risk for progression to regular use and dependence. This is an important question since a nicotine content that
reduces tobacco use and dependence among daily smokers could conceivably support continued
experimentation and progression to dependence among non-daily smokers. The overarching goal of the
proposed research is to evaluate reactions to, and choices to self-administer, cigarette smoke with varying
nicotine content among low-frequency, non-dependent adolescent/young adult smokers between the ages of
18-25 yrs. The proposed sample (n=90) approximates the age and smoking patterns of individuals
experimenting with cigarettes and as such, will provide critical information about the role of nicotine content in
promoting and sustaining continued experimentation and progression to use. Participants will undergo three
sessions in which their reactions to fixed doses of smoke from investigational cigarettes with three different
nicotine contents (15.8 mg/gram of tobacco, 2.5 mg/g, and .4 mg/g). Following the third fixed-dose session,
participants will return to the lab to choose one of the cigarettes to self-administer. Order of the fixed-dose
sessions will be counterbalanced and randomly assigned; all tests will be conducted double-blind. We
hypothesize that intermediate nicotine content cigarettes will produce greater positive reactions than very low
nicotine content cigarettes and less negative reactions than normal nicotine content cigarettes. Participants will
choose to self-administer intermediate content cigarettes over the others. The proposed research will provide
an evaluation of the amount of nicotine in cigarette smoke that produces reactions associated with progression
from initial smoking to nicotine dependence in a sample representative of individuals experimenting with
cigarette use. Specifically, observing that a nicotine content level (2.4 mg/g) that reduces smoking among
dependent, daily smokers, results in reactions and choices that are associated with progression to regular
smoking and dependence, can have a significant impact in establishing new cigarette product standards.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Impact of new standards for tobacco products among dual e-cigarette/combusted cigarette users
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批准号:10160863
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项目类别:
-
资助金额:$47.19万
-
财政年份:2019
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负责人:Francis Joseph McClernon
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依托单位:
Environment Cue-Reactivity: Brain, Behavior and Clinical Outcomes in Tobacco Use
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批准号:8786243
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项目类别:
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资助金额:$42.62万
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财政年份:2014
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负责人:Francis Joseph McClernon
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依托单位:
Environment Cue-Reactivity: Brain, Behavior and Clinical Outcomes in Tobacco Use
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批准号:9282738
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项目类别:
-
资助金额:$49.42万
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财政年份:2014
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负责人:Francis Joseph McClernon
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依托单位:
Environment Cue-Reactivity: Brain, Behavior and Clinical Outcomes in Tobacco Use
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批准号:9064181
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项目类别:
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资助金额:$46.83万
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财政年份:2014
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负责人:Francis Joseph McClernon
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依托单位:
Environment Cue-Reactivity: Brain, Behavior and Clinical Outcomes in Tobacco Use
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批准号:8918572
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项目类别:
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资助金额:$45.46万
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财政年份:2014
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负责人:Francis Joseph McClernon
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依托单位:
Resting State Functional Connectivity and Addiction at Duke (RAD) Repository
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批准号:8526624
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项目类别:
-
资助金额:$8.36万
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财政年份:2012
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负责人:Francis Joseph McClernon
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依托单位:
Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments
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批准号:8400691
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项目类别:
-
资助金额:$24.49万
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财政年份:2012
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负责人:Francis Joseph McClernon
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依托单位:
Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments
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批准号:8507195
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项目类别:
-
资助金额:$27.17万
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财政年份:2012
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负责人:Francis Joseph McClernon
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依托单位:
Development of a Smartphone-Based Virtual Sensor for Detecting Smoking Behavior
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批准号:8402249
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项目类别:
-
资助金额:$19.63万
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财政年份:2012
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负责人:Francis Joseph McClernon
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依托单位:
Neuroimaging Studies
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批准号:8375651
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项目类别:
-
资助金额:$8.3万
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财政年份:2012
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负责人:Francis Joseph McClernon
-
依托单位:
Development of a Smartphone-Based Virtual Sensor for Detecting Smoking Behavior
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批准号:8494033
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项目类别:
-
资助金额:$18.84万
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财政年份:2012
-
负责人:Francis Joseph McClernon
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依托单位:
Neuroimaging Studies
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批准号:8004224
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项目类别:
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资助金额:$9.13万
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财政年份:2010
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负责人:Francis Joseph McClernon
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依托单位:
Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine Dependence
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批准号:8432059
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项目类别:
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资助金额:$32.36万
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财政年份:2009
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负责人:Francis Joseph McClernon
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依托单位:
Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine Dependence
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批准号:8092867
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项目类别:
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资助金额:$33.71万
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财政年份:2009
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负责人:Francis Joseph McClernon
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依托单位:
Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine Dependence
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批准号:7777886
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项目类别:
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资助金额:$34.75万
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财政年份:2009
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负责人:Francis Joseph McClernon
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依托单位:
Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine Dependence
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批准号:7581390
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项目类别:
-
资助金额:$37.84万
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财政年份:2009
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负责人:Francis Joseph McClernon
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依托单位:
Brain Substrates of Extinction-Based Treatment for Nicotine Dependence
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批准号:7848887
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项目类别:
-
资助金额:$38.61万
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财政年份:2008
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负责人:Francis Joseph McClernon
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依托单位:
Brain Substrates of Extinction-Based Treatment for Nicotine Dependence
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批准号:8264209
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项目类别:
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资助金额:$37.45万
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财政年份:2008
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负责人:Francis Joseph McClernon
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依托单位:
Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction
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批准号:7462880
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项目类别:
-
资助金额:$33.35万
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财政年份:2008
-
负责人:Francis Joseph McClernon
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依托单位:
Brain Substrates of Extinction-Based Treatment for Nicotine Dependence
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批准号:8081712
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项目类别:
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资助金额:$37.45万
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财政年份:2008
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负责人:Francis Joseph McClernon
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依托单位:
海外基金