Emotional modulation of human memory processes and corticohippocampal systems

人类记忆过程和皮质海马系统的情绪调节

• 批准号: 9269373
• 负责人: Maureen Ritchey
• 金额: $ 24.7万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9269373
• 关键词: Accounting; Address; Affect; Amygdaloid structure; Anterior; Area; Arousal; Automobile Driving; Award; Base of the Brain; Behavioral; Binding; Boston; Brain; Complex; Disease; Electric Stimulation; Electroencephalography; Emotional; Emotions; Environment; Episodic memory; Foundations; Functional Magnetic Resonance Imaging; Hippocampus (Brain); Human; Image; Impairment; Intervention; Investigation; Laboratory Research; Learning; Link; Maintenance; Major Depressive Disorder; Medial; Mediating; Memory; Memory impairment; Mental disorders; Mentors; Methods; Modeling; Neurobiology; Patients; Phase; Post-Traumatic Stress Disorders; Process; Property; Psychology; Research; Research Proposals; Resolution; Resources; Retrieval; Role; Scalp structure; Structure; System; Temporal Lobe; Testing; Time; Training; Work; abstracting; cognitive neuroscience; college; efficacy testing; improved; innovation; insight; memory process; nervous system disorder; neuromechanism; novel; planetary Atmosphere; post-doctoral training; programs; public health relevance; relating to nervous system; research study

Modified Project Summary/Abstract Section The proposed research will be completed at Boston College as part of the R00 phase of the award. Emotion has complex effects on episodic memory, enhancing certain aspects of memory, such as item recognition, but not other forms of memory, such as memory for context. Yet, the mechanisms underlying these phenomena are poorly understood. In general, episodic memories depend on the integrity of neural structures within the medial temporal lobes, and these structures are connected with two distinct cortico-hippocampal systems. The amygdala—known to mediate emotion effects on memory— is differentially connected with these systems, leading to the proposal that emotional memory effects can be explained in terms of differential modulation of cortico-hippocampal systems. The proposed research will address these questions by using a combination of functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and transcranial electrical stimulation (tES). These methods will allow investigation of how emotion influences activity in cortical and hippocampal regions and alters the oscillatory signatures of memory processes. During the mentored phase of the proposal, which was conducted at UC Davis with Drs. Charan Ranganath and Andrew Yonelinas, the candidate obtained new training in high-resolution fMRI and EEG/ tES. During the current independent phase of the proposal, the candidate will use these methods to test novel predictions about the roles of cortico-hippocampal systems and theta oscillations in driving emotional memory phenomena. The candidate will establish her research laboratory dedicated to the cognitive neuroscience of memory and its modulation by emotion. The research environment at Boston College is optimal for this work. Boston College has committed substantial resources to psychology research, offering facilities and resources within the department and access to world-class imaging facilities in the Boston area. Thus, the research plan builds on a strong foundation of training, and it will take place in an atmosphere conducive to productive research. The results will significantly advance current understanding of the neural mechanisms supporting arousal-mediated memory modulation.

修改后的项目摘要/摘要部分 这项拟议的研究将在波士顿学院完成，作为该奖项R00阶段的一部分。情绪对情景记忆有复杂的影响，可以增强记忆的某些方面，如项目识别，但不能增强其他形式的记忆，如背景记忆。然而，人们对这些现象背后的机制知之甚少。一般来说，情景记忆依赖于内侧颞叶内神经结构的完整性，这些结构与两个不同的皮质-海马区系统相连。杏仁核--已知的调节情绪对记忆的影响--与这些系统有不同的联系，导致了一种观点，即情绪记忆效应可以通过皮质-海马体系统的不同调制来解释。这项拟议的研究将结合使用功能磁共振成像(FMRI)、脑电(EEG)和经颅电刺激(TES)来解决这些问题。这些方法将有助于研究情绪如何影响大脑皮层和海马区的活动，并改变记忆过程的振荡特征。在加州大学戴维斯分校与Charan Ranganath博士和Andrew Yonelinas博士一起进行的提案的指导阶段，候选人获得了高分辨率fMRI和EEG/TES方面的新培训。在提案目前的独立阶段，候选人将使用这些方法来测试关于皮质-海马体系统和theta振荡在驱动情绪记忆现象中的作用的新预测。这位候选人将建立她的研究实验室，致力于研究记忆的认知神经科学及其情绪调节。波士顿学院的研究环境最适合这项工作。波士顿学院在心理学研究上投入了大量资源，在系内提供设施和资源，并在波士顿地区提供世界级的成像设施。因此，研究计划建立在坚实的培训基础上，并将在有利于生产性研究的气氛中进行。这一结果将极大地促进当前对支持唤醒中介记忆调制的神经机制的理解。