Emotional modulation of human memory processes and corticohippocampal systems

修改项目摘要/摘要部分 拟议的研究将在波士顿学院完成，作为该奖项R 00阶段的一部分。情绪对情景记忆有着复杂的影响，它能增强记忆的某些方面，比如项目识别，但不能增强其他形式的记忆，比如对背景的记忆。然而，这些现象背后的机制知之甚少。一般来说，情景记忆依赖于内侧颞叶内神经结构的完整性，这些结构与两个不同的皮质-海马系统相连。杏仁核-已知介导情绪对记忆的影响-与这些系统有差异，导致情绪记忆效应可以用皮质-海马系统的差异调制来解释。拟议的研究将通过使用功能性磁共振成像（fMRI），脑电图（EEG）和经颅电刺激（tES）的组合来解决这些问题。这些方法将允许调查情绪如何影响皮层和海马区域的活动，并改变记忆过程的振荡特征。在加州大学戴维斯分校与Charan Ranganath博士和Andrew Yonelinas博士一起进行的建议的指导阶段，候选人获得了高分辨率fMRI和EEG/ tES的新培训。在提案的当前独立阶段，候选人将使用这些方法来测试关于皮质海马系统和θ振荡在驱动情绪记忆现象中的作用的新预测。候选人将建立她的研究实验室，致力于记忆的认知神经科学及其情绪调节。波士顿学院的研究环境是这项工作的最佳选择。波士顿学院已承诺大量的资源，心理学研究，提供设施和资源的部门和访问世界一流的成像设施在波士顿地区。因此，研究计划将建立在坚实的培训基础上，并将在有利于进行富有成效的研究的气氛中进行。这一结果将大大推进目前对支持觉醒介导的记忆调制的神经机制的理解。

Modified Project Summary/Abstract Section The proposed research will be completed at Boston College as part of the R00 phase of the award. Emotion has complex effects on episodic memory, enhancing certain aspects of memory, such as item recognition, but not other forms of memory, such as memory for context. Yet, the mechanisms underlying these phenomena are poorly understood. In general, episodic memories depend on the integrity of neural structures within the medial temporal lobes, and these structures are connected with two distinct cortico-hippocampal systems. The amygdala—known to mediate emotion effects on memory— is differentially connected with these systems, leading to the proposal that emotional memory effects can be explained in terms of differential modulation of cortico-hippocampal systems. The proposed research will address these questions by using a combination of functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and transcranial electrical stimulation (tES). These methods will allow investigation of how emotion influences activity in cortical and hippocampal regions and alters the oscillatory signatures of memory processes. During the mentored phase of the proposal, which was conducted at UC Davis with Drs. Charan Ranganath and Andrew Yonelinas, the candidate obtained new training in high-resolution fMRI and EEG/ tES. During the current independent phase of the proposal, the candidate will use these methods to test novel predictions about the roles of cortico-hippocampal systems and theta oscillations in driving emotional memory phenomena. The candidate will establish her research laboratory dedicated to the cognitive neuroscience of memory and its modulation by emotion. The research environment at Boston College is optimal for this work. Boston College has committed substantial resources to psychology research, offering facilities and resources within the department and access to world-class imaging facilities in the Boston area. Thus, the research plan builds on a strong foundation of training, and it will take place in an atmosphere conducive to productive research. The results will significantly advance current understanding of the neural mechanisms supporting arousal-mediated memory modulation.