IGF::OT::IGF Centralized Omics REsource (CORE)

NHLBI精准医学反式组学（TOPMed）项目将通过收集和结合全基因组测序（WGS）和其他组学数据（例如DNA甲基化特征、RNA表达谱、代谢物谱），以及来自心脏、肺、血液和睡眠（HLBS）疾病研究的分子、行为、成像、环境和临床数据，支持该研究所更大的精准医学计划。

The NHLBI Trans-Omics for Precision Medicine (TOPMed) program will support the Institute’s larger precision medicine initiative by collecting and coupling whole-genome sequencing (WGS) and other -omics data (e.g., DNA methylation signature, RNA expression profiles, metabolite profiles) with molecular, behavioral, imaging, environmental, and clinical data from studies focused on heart, lung, blood and sleep (HLBS) disorders. The TOPMed program aims to: •Collect and assemble -omics (RNASeq, methylation, metabolomics, epigenomics, and proteomics) data with WGS and clinical outcomes data across diverse populations including those traditionally underrepresented in research. •Build a data commons repository that the scientific community can use for future research and to enable precision medicine. •Stimulate systems medicine approaches that help organize data to ensure they are accessible and interpretable for health disease research. •Promote discoveries about the fundamental mechanisms that underlie HLBS disorders.