EXERCISE OPTION PERIOD 1, TASK AREA 5 METABOLOMICS, FOR CORE YEAR 5.

核心第 5 年练习选项第 1 期，任务领域 5 代谢组学。

• 批准号: 10706416
• 负责人: RICHARD GIBBS
• 金额: $ 837.8万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-25 至 2023-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10706416
• 关键词: Area; Blood; Consent; Data; Ensure; Exercise; Generations; Genomics; Goals; Heart; Human; Informatics; Lung; Manuals; Measures; Medicine; Methods; National Heart, Lung, and Blood Institute; Phenotype; Plasma; Protocols documentation; Quality Control; Reporting; Research; Sampling; Secure; Serum; Services; Sleep; TimeLine; Trans-Omics for Precision Medicine; college; data exchange; experience; flexibility; human genome sequencing; meetings; metabolomics; operation; preference; programs; repository; tool

Safeguarding the integrity of the samples, their associated information, and their corresponding data is of the utmost importance to the Baylor College of Medicine (BCM) and Metabolon. Accordingly, both BCM and Metabolon are amenable and flexible to the NHLBI preferences concerning sample chain of custody and secure data transfers. Our academic partner, with whom Metabolon has extensive working experience, also has these protocols in place due to their own extensive experience in receiving genomic samples. We are committed to working with NHLBI to provide confidence in our workflow for all TOPMed CORE projects. To meet the goals of this solicitation, we will provide a manual of operations, receive and manage plasma or serum samples from the BCM Human Genome Sequencing Center (HGSC) and the TOPMed Project Studies, transfer these samples to Metabolon or per NHLBI preference have Metabolon directly receive and manage samples while adhering to defined protocols and timelines, return normalized and analysis-ready metabolomics results to the Project Studies via the TOPMed IRC, provide necessary bi-weekly and close out reports, and participate in meetings to ensure the successful completion of our objectives. If requested, we can provide expertise and tools for analyzing heart, lung, blood and sleep-related phenotypes with these metabolomics data. The objectives of Task 5 outlined in the solicitation will be accomplished by pursing the following aims:

保护样本、相关信息和相应数据的完整性对于贝勒医学院 (BCM) 和 Metabolon 至关重要。因此，BCM 和 Metabolon 都能够灵活地适应 NHLBI 关于样本监管链和安全数据传输的偏好。我们的学术合作伙伴 Metabolon 拥有丰富的工作经验，由于他们在接收基因组样本方面拥有丰富的经验，因此也制定了这些协议。我们致力于与 NHLBI 合作，为所有 TOPMed CORE 项目的工作流程提供信心。 为了实现本次征集的目标，我们将提供操作手册，接收和管理来自 BCM 人类基因组测序中心 (HGSC) 和 TOPMed 项目研究的血浆或血清样本，将这些样本转移到 Metabolon 或根据 NHLBI 的偏好，让 Metabolon 直接接收和管理样本，同时遵守规定的方案和时间表，通过 TOPMed IRC，提供必要的双周报告和结束报告，并参加会议以确保成功完成我们的目标。如果需要，我们可以提供专业知识和工具，利用这些代谢组学数据分析心脏、肺、血液和睡眠相关表型。招标中概述的任务 5 的目标将通过追求以下目标来实现：