EXERCISE OPTION PERIOD 1, TASK AREA 5 METABOLOMICS, FOR CORE YEAR 5.

保护样本的完整性，其相关信息，以及其相应的数据是最重要的贝勒医学院（医学院）和代谢。因此，在样品监管链和安全数据传输方面，NHLBI和Metabolon都能灵活地遵守NHLBI的偏好。我们的学术合作伙伴Metabolon拥有丰富的工作经验，由于他们在接收基因组样本方面拥有丰富的经验，他们也制定了这些协议。我们致力于与NHLBI合作，为所有TOPMed CORE项目的工作流程提供信心。 为了实现本次征集的目标，我们将提供操作手册，接收和管理来自美国国家生物技术研究所人类基因组测序中心（HGSC）和TOPMed项目研究的血浆或血清样本，将这些样本转移到Metabolon或根据NHLBI的偏好，让Metabolon直接接收和管理样本，同时遵守规定的方案和时间表，通过TOPMed IRC向项目研究返回标准化和分析就绪的代谢组学结果，提供必要的双周报告和结束报告，并参加会议以确保成功完成我们的目标。如果需要，我们可以提供专业知识和工具，用于分析心脏，肺，血液和睡眠相关的表型与这些代谢组学数据。招标中概述的任务5的目标将通过追求以下目标来实现：

Safeguarding the integrity of the samples, their associated information, and their corresponding data is of the utmost importance to the Baylor College of Medicine (BCM) and Metabolon. Accordingly, both BCM and Metabolon are amenable and flexible to the NHLBI preferences concerning sample chain of custody and secure data transfers. Our academic partner, with whom Metabolon has extensive working experience, also has these protocols in place due to their own extensive experience in receiving genomic samples. We are committed to working with NHLBI to provide confidence in our workflow for all TOPMed CORE projects. To meet the goals of this solicitation, we will provide a manual of operations, receive and manage plasma or serum samples from the BCM Human Genome Sequencing Center (HGSC) and the TOPMed Project Studies, transfer these samples to Metabolon or per NHLBI preference have Metabolon directly receive and manage samples while adhering to defined protocols and timelines, return normalized and analysis-ready metabolomics results to the Project Studies via the TOPMed IRC, provide necessary bi-weekly and close out reports, and participate in meetings to ensure the successful completion of our objectives. If requested, we can provide expertise and tools for analyzing heart, lung, blood and sleep-related phenotypes with these metabolomics data. The objectives of Task 5 outlined in the solicitation will be accomplished by pursing the following aims: