The NINDS Human Cell and Data Repository
NINDS 人类细胞和数据存储库
基本信息
- 批准号:9150320
- 负责人:
- 金额:$ 117.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-30 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAlzheimer&aposs DiseaseAmyotrophic Lateral SclerosisAreaAutomationBiopsyBloodBlood CellsCatalogingCatalogsCell LineCellsCentral Nervous System DiseasesCollaborationsCollecting CellCollectionCommunitiesDNADataDatabasesDerivation procedureDevelopmentDiseaseDisease modelDystoniaEmerging TechnologiesEnsureEthicsFibroblastsGene-ModifiedGenerationsGenomicsGoalsHousingHumanHuntington DiseaseIndividualInformaticsInstructionInternationalLymphocyteMaintenanceMedicineMethodologyMissionMutationNational Institute of Drug AbuseNational Institute of Mental HealthNational Institute of Neurological Disorders and StrokeNeurodegenerative DisordersNeuronsNeurosciencesOnline SystemsPaperParkinson DiseaseParticipantPharmaceutical PreparationsPlayPluripotent Stem CellsPositioning AttributePreclinical Drug EvaluationPriceProcessProductionProtocols documentationPublicationsQuality ControlRecording of previous eventsRegenerative MedicineReportingResearchResearch PersonnelResourcesRoleSamplingSecureServicesShippingShipsSkinSourceSpecimenStem Cell ResearchStem cellsTechnologyTestingTherapeuticTissue SampleTissuesUnited States National Institutes of HealthUniversitiesValidationWashingtonWorkbiobankblastomere structurecell registrycell typecostdesignexhibitionsfallsfrontotemporal degenerationgenetic resourcegenome editinghuman diseaseimprovedinduced pluripotent stem cellinterestmedical schoolsmeetingsnerve stem cellnewsnovelnovel strategiespluripotencyprospectivepublic health relevancequality assurancerepairedrepositoryresearch and developmentsample collectiontechnology developmenttherapeutic developmenttooltool developmentuser-friendlyweb portalweb site
项目摘要
DESCRIPTION (provided by applicant): Human pluripotent stem cells that can give rise to almost any type of cell were originally isolated from embryonic cells and their utility as tools fo research and therapeutic development was severely restricted due to ethical considerations as well as the inability to derive stem cells from subjects with known disorders. The relatively recent development of technologies for deriving induced pluripotent stem cells (iPSCs) from cells that were previously thought to be "terminally" differentiated, such as skin or blood cells, has opened up nearly limitless new avenues for understanding human disease and developing novel approaches for treatment. By converting cells collected from affected individuals into iPSCs, and then to relevant cell types such as neurons for central nervous system disorders, we can create "disease models in a dish", cells that recapitulate the disorder and can be used to screen therapeutic drugs or study the manifestation of the disorder and elucidate its origins. The NINDS Repository was created to collect and distribute a variety of human cells such as skin fibroblasts and blood cells and convert these to iPSCs for research in the areas of neurodegenerative disease such as Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, Dystonia and Frontotemporal Degeneration. Given the complexity and cost of generating iPSC lines of high quality, and the emerging importance of disease modeling and regenerative medicine, there is a tremendous need in the neuroscience field for a reliable centralized source of these materials. RUCDR Infinite Biologics (RUCDR) is uniquely positioned to provide this resource for the NINDS. RUCDR has a long and successful track record as a repository and genetic resource since its inception in 1998. RUCDR manages several major repositories for the NIH, including the NIMH Repository and Genomics Resource (NRGR) which encompasses the NIMH Stem Cell Resource. The mission of the RUCDR NINDS Stem Cell Repository will be to work with NINDS investigators and staff on all aspects of study management to collect, process and distribute the highest quality cell samples from participants in its studies. These will include the culturing of fibroblasts from skin biopsies, th isolation of lymphocytes from blood, and the derivation of iPSC lines from both cell types. RUCDR will then perform a comprehensive range of tests on the iPSCs to ensure their quality, pluripotency and identity. RUCDR will provide additional services to the global community, including the generation of neural stem cells (NSCs), different types of neurons, and genome editing to repair or introduce in iPSCs specific mutations that are implicated in human disease.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JAY Arnold TISCHFIELD', 18)}}的其他基金
National Epidemiologic Survey on Alcohol and Related Conditions: DNA Repository
全国酒精及相关疾病流行病学调查:DNA 存储库
- 批准号:
8774135 - 财政年份:2011
- 资助金额:
$ 117.57万 - 项目类别:
National Epidemiologic Survey on Alcohol and Related Conditions: DNA Repository
全国酒精及相关疾病流行病学调查:DNA 存储库
- 批准号:
9124343 - 财政年份:2011
- 资助金额:
$ 117.57万 - 项目类别:
National Epidemiologic Survey on Alcohol and Related Conditions: DNA Repository
全国酒精及相关疾病流行病学调查:DNA 存储库
- 批准号:
8267196 - 财政年份:2011
- 资助金额:
$ 117.57万 - 项目类别:
National Epidemiologic Survey on Alcohol and Related Conditions: DNA Repository
全国酒精及相关疾病流行病学调查:DNA 存储库
- 批准号:
8386959 - 财政年份:2011
- 资助金额:
$ 117.57万 - 项目类别:
National Epidemiologic Survey on Alcohol and Related Conditions: DNA Repository
全国酒精及相关疾病流行病学调查:DNA 存储库
- 批准号:
8579866 - 财政年份:2011
- 资助金额:
$ 117.57万 - 项目类别:
Rutgers University Cell and DNA Repository Renovation
罗格斯大学细胞和 DNA 储存库翻新
- 批准号:
7896252 - 财政年份:2010
- 资助金额:
$ 117.57万 - 项目类别: