Prevention of weight regain (POWeR) and cognitive funtion

描述（由申请人提供）：申请人阿曼达萨博博士接受了身体活动（PA）认知能力和衰老领域的研究生培训，目前正在接受体重管理方面的博士后培训。Szabo博士对减肥和维持体重对超重和肥胖成年人执行控制的影响产生了兴趣，并正在寻求专门的培训时间，以扩大她在这一领域的经验，沿着进行体重管理试验和临床试验研究数据分析的正式培训。Szabo博士和她的导师团队已经确定了一个培训计划，以解决她以前的培训差距。Szabo博士的培训计划目标包括：1）获得专注于体重管理的临床试验研究的实践经验（HL 11842，PI - Donnelly）在堪萨斯大学医学中心，2）获得临床试验研究的收集和数据分析方面的经验和培训，沿着分析执行性能数据的技术方面的具体培训，3）参加每周的研究者和期刊俱乐部会议，观察，讨论和参与几项正在进行的NIH研究，并有一个专门的场地来讨论当前和未来的手稿/研究赠款，4）每年参加最多7次专业发展和临床试验研讨会，并接受负责任地开展研究的培训，5）每年开发2篇第一作者手稿供出版，以及6）开发和完成赠款申请（例如，NIH K奖- K99/R 00）。POWeR研究为Szabo博士提供了一个绝佳而及时的机会，以增加经验，这将进一步推动她成为一名独立资助的研究人员，进行体重管理干预和评估执行控制。F32机制将为Szabo博士提供专门的时间，以提高她在体重管理干预措施、负责任的研究行为、研究管理、数据收集、研究设计以及缺失数据和临床试验的先进数据分析技术方面的知识和技能。除了这些培训经验外，Szabo博士还提出了POWeR研究中以前没有计划的数据收集和分析的独特领域。Szabo博士计划1）确定一个典型的减肥计划，包括饮食和运动，如何影响执行控制和2）确定如何运动和体重变化在12个月的体重维持期影响执行控制。萨博博士迄今为止的培训将提供一个坚实的基础，以建立在她获得的第一手经验，在她的培训存在差距的领域。F32奖将提供必要的财政援助和保护时间，以成功实现这些培训目标，并提供成功的过渡到独立。

DESCRIPTION (provided by applicant): The applicant, Dr. Amanda Szabo, underwent graduate training in the area of physical activity (PA) cognitive performance and aging and is currently in post-doctoral training in weight management. Dr. Szabo has developed an interest in the impact of weight loss and maintenance on executive control in over weight and obese adults and is seeking dedicated training time to expand her experience in this area along with formal training in conducting weight management trials and data analysis for clinical trials research. Dr. Szabo and her mentorship team have identified a training plan to address gaps in her previous training. Dr. Szabo's training plan objectives include 1) obtaining hands on experience in clinical trial research focused on weight management (HL11842, PI - Donnelly) at the University of Kansas Medical Center, 2) gaining experience and training in collection and data analysis for clinical trial research along with specific training in techniques for analyzing executive performance data, 3) attending weekly investigator and journal club meetings to observe, discuss and participate in several ongoing NIH studies and have a dedicated venue to discuss current and future manuscripts/research grants, 4) participating in up to 7 professional development and clinical trial seminars each year and training in the responsible conduct of research, 5) developing 2 first-author manuscripts for publication each year, and 6) developing and completing a grant application (e.g., NIH K award - K99/R00). The POWeR study provides an excellent and timely opportunity for Dr. Szabo to add experiences that will further her development towards becoming an independent funded investigator conducting weight management interventions and assessing executive control. The F32 mechanism will support Dr. Szabo with dedicated time to advance her knowledge and skills in weight management interventions, the responsible conduct of research, study administration, data collection, research design, and advanced data analysis techniques for missing data and for clinical trials. In addition to these training experiences, Dr. Szabo has proposed unique areas of data collection and analysis previously not planned in the POWeR study. Dr. Szabo plans to 1) to determine how a typical weight loss program, consisting of diet and exercise, impacts executive control and 2) to determine how exercise and weight change over a 12 month weight maintenance period impacts executive control. Dr. Szabo's training to date will provide a solid foundation to build upon as she gains first- hand experience in areas where gaps in her training exist. The F32 award will provide the financial assistance and protected time necessary to successfully achieve these training objectives and provide a successful transition to independence.