Prevention of weight regain (POWeR) and cognitive funtion

描述(申请人提供)：申请者Amanda Szabo博士接受了体力活动(PA)认知表现和衰老领域的研究生培训，目前正在进行体重管理方面的博士后培训。Szabo博士对减肥和维持体重对超重和肥胖成年人执行控制的影响产生了兴趣，她正在寻找专门的培训时间来扩大她在这一领域的经验，同时还在进行体重管理试验和临床试验研究的数据分析方面的正式培训。Szabo博士和她的指导团队已经确定了一个培训计划，以弥补她之前培训中的不足。Szabo博士的培训计划目标包括1)在堪萨斯大学医学中心获得以体重管理为重点的临床试验研究(HL11842，Pi-Donnelly)的实践经验，2)获得临床试验研究的收集和数据分析方面的经验和培训，以及分析高管绩效数据的具体培训，3)参加每周研究员和期刊俱乐部会议，观察、讨论和参与正在进行的几项NIH研究，并拥有专门的场所讨论当前和未来的手稿/研究拨款，4)每年参加多达7次专业发展和临床试验研讨会，并培训负责任的研究工作，5)每年开发2份第一作者手稿以供出版；6)开发并完成一项拨款申请(例如，NIH K奖-K99/R00)。POWER研究为Szabo博士提供了一个极好和及时的机会，让她增加经验，进一步发展成为一名独立资助的研究员，进行体重管理干预和评估执行控制。F32机制将为Szabo博士提供专门的时间，以提高她在体重管理干预、负责任的研究实施、研究管理、数据收集、研究设计以及针对缺失数据和临床试验的先进数据分析技术方面的知识和技能。除了这些培训经验，Szabo博士还提出了POWER研究中之前没有计划的数据收集和分析的独特领域。萨博博士计划：1)确定由饮食和锻炼组成的典型减肥计划对执行控制的影响；2)确定锻炼和体重在12个月的体重维持期内的变化对执行控制的影响。Szabo博士迄今为止的培训将提供坚实的基础，因为她在培训中存在差距的领域获得了第一手经验。F32奖励将提供必要的财政援助和受保护的时间，以成功实现这些培训目标，并成功过渡到独立。

DESCRIPTION (provided by applicant): The applicant, Dr. Amanda Szabo, underwent graduate training in the area of physical activity (PA) cognitive performance and aging and is currently in post-doctoral training in weight management. Dr. Szabo has developed an interest in the impact of weight loss and maintenance on executive control in over weight and obese adults and is seeking dedicated training time to expand her experience in this area along with formal training in conducting weight management trials and data analysis for clinical trials research. Dr. Szabo and her mentorship team have identified a training plan to address gaps in her previous training. Dr. Szabo's training plan objectives include 1) obtaining hands on experience in clinical trial research focused on weight management (HL11842, PI - Donnelly) at the University of Kansas Medical Center, 2) gaining experience and training in collection and data analysis for clinical trial research along with specific training in techniques for analyzing executive performance data, 3) attending weekly investigator and journal club meetings to observe, discuss and participate in several ongoing NIH studies and have a dedicated venue to discuss current and future manuscripts/research grants, 4) participating in up to 7 professional development and clinical trial seminars each year and training in the responsible conduct of research, 5) developing 2 first-author manuscripts for publication each year, and 6) developing and completing a grant application (e.g., NIH K award - K99/R00). The POWeR study provides an excellent and timely opportunity for Dr. Szabo to add experiences that will further her development towards becoming an independent funded investigator conducting weight management interventions and assessing executive control. The F32 mechanism will support Dr. Szabo with dedicated time to advance her knowledge and skills in weight management interventions, the responsible conduct of research, study administration, data collection, research design, and advanced data analysis techniques for missing data and for clinical trials. In addition to these training experiences, Dr. Szabo has proposed unique areas of data collection and analysis previously not planned in the POWeR study. Dr. Szabo plans to 1) to determine how a typical weight loss program, consisting of diet and exercise, impacts executive control and 2) to determine how exercise and weight change over a 12 month weight maintenance period impacts executive control. Dr. Szabo's training to date will provide a solid foundation to build upon as she gains first- hand experience in areas where gaps in her training exist. The F32 award will provide the financial assistance and protected time necessary to successfully achieve these training objectives and provide a successful transition to independence.