Differential Effects of Exercise Modality on Cognition and Brain in Older Adults

运动方式对老年人认知和大脑的不同影响

基本信息

批准号：
10622470
负责人：
Amanda N. Szabo-Reed
金额：
$ 151.54万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10622470
关键词：
Address Aerobic Aerobic Exercise Age Age-associated memory impairment Aging Alzheimer&apos s Disease American Attenuated Bioenergetics Biological Biological Markers Blood Chemical Analysis Blood Platelets Body Composition Body fat Brain Brain region Brain-Derived Neurotrophic Factor Cerebrovascular Circulation Cities Clinical Clinical Trials Cognition Cognitive Communities Consensus Dementia Development Dose Elderly Enrollment Equilibrium Exercise Fatty acid glycerol esters Functional Magnetic Resonance Imaging Future Gait Goals Health Care Costs Health Policy Health education Healthcare Systems Impaired cognition Individual Insulin Resistance Insulin-Like Growth Factor I Kansas Knowledge Life Link Maintenance Measures Mediating Modality Multi-Institutional Clinical Trial Muscle function Neuropsychology Oxygen Consumption Participant Phase Physical Exercise Physical Function Physical activity Physiological Plasma Public Health Quality of life Randomized Recommendation Research Resistance Resources Rest Science Structure Testing Translating United States National Institutes of Health Walking Weight Lifting active lifestyle aging population arm arterial spin labeling brain health brain magnetic resonance imaging brain volume cardiorespiratory fitness cognitive benefits cognitive function cognitive performance community setting comparison control exercise intervention exercise program exercise training experience flexibility functional gain group intervention hippocampal atrophy improved mode of exercise muscle form muscle strength physical conditioning prevent programs resistance exercise

项目摘要

Project Summary Older adults often experience physical decline that can be directly ameliorated by physical activity and exercise. Evidence is building that exercise prevents cognitive decline or delays the onset of debilitating dementia (e.g. Alzheimer's disease [AD]) yet, the optimal dose and combination of exercise modalities for promoting brain health, however, remains unknown and essentially untested. Our long-term research goal is to develop and test strategies to support successful aging and prevent AD. We have successful ongoing (R01AG053312, R01AG053952, R01AG049749, R01AG52954, R01AG043962) and completed projects (R01AG033673, R01AG034614, KL2TR000119) around a theme of community-based exercise programs for older adults. We will enroll 280 individuals, age 65 to 80 years without cognitive impairment, into a 52-week exercise intervention to test the combined and independent effects of aerobic and resistance training on cognition, brain structure, and physical function. We will also explore underlying biological mechanisms that may link exercise with brain health. Participants will be randomized into 1 of 4 groups: flexibility, toning and balance (control), aerobic exercise training, progressive resistance training, or combined aerobic and resistance training. All intervention groups represent the most common modalities of exercise and directly reflect the public health recommendations for aerobic and resistance training. Exercise training will occur in a community setting through the network of Greater Kansas City YMCAs. We hypothesize that 52 weeks of exercise will improve 1) cognitive performance, 2) regional brain volume, 3) cardiorespiratory fitness and strength 4) biomarkers. This will be the largest study to assess the combined and independent effects of the two most recommended forms of exercise. Demonstrating specific exercise effects on cognitive function and brain health in older adults would have enormous public health implications. The study's results will also impact public health policy and education by providing evidence towards the specific or synergistic effects of aerobic and resistance training on cognition and brain structure. Encouraging the public to adapt more active lifestyles and stimulate the development of effective exercise delivery programs to enhance initiation and maintenance of physical activity interventions is key to increasing the number of quality years of life for America's aging population.

项目摘要老年人经常经历身体下降，可以通过身体直接改善活动和锻炼。有证据表明，运动可以防止认知能力下降或延迟发作衰弱的痴呆症（例如阿尔茨海默氏病[AD]），锻炼的最佳剂量和组合然而，促进大脑健康的方式仍然未知且基本未经测试。我们的长期研究目标是制定和测试策略，以支持成功的衰老和防止广告。我们已经成功进行（R01AG053312，R01AG053952，R01AG049749，R01AG52954， R01AG043962）并完成项目（R01AG033673，R01AG034614，KL2TR000119）针对老年人的社区锻炼计划。我们将注册280个人，年龄65至80岁没有认知障碍，进入52周的运动干预措施，以测试合并和独立有氧和抵抗训练对认知，大脑结构和身体机能的影响。我们也会探索可能将运动与大脑健康联系起来的潜在生物学机制。参与者将被随机分为4组中的1个：柔韧性，调理和平衡（对照），有氧运动运动训练，进行性抵抗训练或有氧和抵抗训练。所有干预小组代表了运动的最常见方式，直接反映了公共卫生有氧和抵抗训练的建议。运动训练将在社区环境中进行通过大堪萨斯城YMCAS的网络。我们假设52周的运动将有所改善 1）认知表现，2）区域大脑体积，3）心肺适应性和力量4）生物标志物。这将是评估两者最大和独立效应的最大研究推荐的运动形式。证明对认知功能和大脑的特定运动影响老年人的健康将具有巨大的公共卫生影响。该研究的结果也会影响公共卫生政策和教育通过提供有氧运动的特定或协同作用的证据以及关于认知和大脑结构的抵抗训练。鼓励公众适应更多积极的生活方式并刺激开发有效的锻炼计划以增强启动和维护体育锻炼干预措施是增加美国衰老的质量生活数量的关键人口。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study.

DOI：
10.3389/fendo.2023.1266692
发表时间：
2023
期刊：
Frontiers in endocrinology
影响因子：
5.2
作者：
通讯作者：

The newly proposed Metabolic Score for Visceral Fat is a reliable tool for identifying non-alcoholic fatty liver disease, requiring attention to age-specific effects in both sexes.

DOI：
10.3389/fendo.2023.1281524
发表时间：
2023
期刊：
Frontiers in endocrinology
影响因子：
5.2
作者：
通讯作者：

An open-source system for efficient clinical trial support: The COMET study experience.

DOI：
10.1371/journal.pone.0293874
发表时间：
2023
期刊：
PloS one
影响因子：
3.7
作者：
通讯作者：

COMbined Exercise Trial (COMET) to improve cognition in older adults: Rationale and methods.

DOI：
10.1016/j.cct.2022.106805
发表时间：
2022-07
期刊：
CONTEMPORARY CLINICAL TRIALS
影响因子：
2.2
作者：
Szabo-Reed, Amanda;Clutton, Jonathan;White, Sydney;Van Sciver, Angela;White, Dreu;Morris, Jill;Martin, Laura;Lepping, Rebecca;Shaw, Ashley;Puchalt, Jaime Perales;Montgomery, Robert;Mahnken, Jonathan;Washburn, Richard;Burns, Jeffrey;Vidoni, Eric D.
通讯作者：
Vidoni, Eric D.