Reservoir Dynamics in Patients Treated in Very Early Acute HIV Infection

极早期急性 HIV 感染患者的储库动态

基本信息

  • 批准号:
    9203883
  • 负责人:
  • 金额:
    $ 65.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-07-01 至 2021-06-30
  • 项目状态:
    已结题

项目摘要

Abstract HIV is not cured with current therapeutic strategies. This is because of a large reservoir of cells with HIV proviral DNA that can reactivate and produce new virus. There is a significant gap in our understanding of the dynamic nature of this reservoir, how is it formed, what cellular and anatomic compartments are important, and how it is replenished. We will take advantage of a unique cohort of HIV infected people in Bangkok, Thailand to address these knowledge gaps. These individuals are identified as being HIV+ even before seroconversion because they are at high-risk for HIV infection and are screened frequently. When they are found to be HIV+ they are enrolled into a prospective study where lymphatic tissues are collected on a longitudinal basis. We will apply state of the art molecular and in situ technologies to these serial samples to define the precise size and location of the reservoir and the impact of very early treatment on reservoir size. For comparison we will study age and sex matched individuals started on treatment during chronic infection. The ability to study individuals at each Fiebig Stage of acute infection provides “snapshots” of the reservoir as it is established and will give us insight into the dynamic nature of its formation, maintenance and replenishment. We hypothesize that viral reservoirs become established as early as Fiebig 1, that the cell type supporting the reservoir differs by anatomic location, and that ongoing, persistent immune activation is a significant factor in its replenishment. These data may point to new therapeutic targets to control or eradicate the latent reservoir which is a critical step in the path to a cure of HIV.
摘要 目前的治疗策略无法治愈艾滋病毒。这是因为一个大型水库 这些细胞带有HIV前病毒DNA,可以重新激活并产生新的病毒。有一个 我们对这个水库的动态性质的理解存在重大差距,它是如何形成的? 形成,什么细胞和解剖隔间是重要的,以及它是如何形成的, 补充。我们将利用一个独特的艾滋病毒感染者群体, 泰国曼谷,以解决这些知识差距。这些人被确认为 即使在血清转换之前也是艾滋病毒阳性,因为他们感染艾滋病毒的风险很高 并经常进行筛查。当他们被发现是艾滋病毒+,他们参加了一个 前瞻性研究,其中纵向收集淋巴组织。我们将 将最先进的分子和原位技术应用于这些系列样品, 水库的精确大小和位置以及早期处理对 水库规模为了比较,我们将研究年龄和性别匹配的个体, 治疗慢性感染。研究每个Fiebig阶段的个体的能力 急性感染的“快照”提供了水库,因为它是建立,并将给予 我们对它的形成、维持和补充的动态性质的洞察力。我们 假设病毒储存库早在Fiebig 1就已经建立, 支持水库的类型因解剖位置而异,持续的,持续的 免疫激活是其补充的重要因素。这些数据可能指向 新的治疗目标,以控制或消除潜在的水库,这是一个关键步骤 在治愈艾滋病毒的道路上。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Timothy W Schacker其他文献

Timothy W Schacker的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Timothy W Schacker', 18)}}的其他基金

Investigation of persistent HIV immune stimulation in lymphoid tissues during therapy as a cause of sustained immune activation
研究治疗期间淋巴组织中持续的 HIV 免疫刺激作为持续免疫激活的原因
  • 批准号:
    10598469
  • 财政年份:
    2020
  • 资助金额:
    $ 65.43万
  • 项目类别:
Investigation of persistent HIV immune stimulation in lymphoid tissues during therapy as a cause of sustained immune activation
研究治疗期间淋巴组织中持续的 HIV 免疫刺激作为持续免疫激活的原因
  • 批准号:
    10011279
  • 财政年份:
    2020
  • 资助金额:
    $ 65.43万
  • 项目类别:
Investigation of persistent HIV immune stimulation in lymphoid tissues during therapy as a cause of sustained immune activation
研究治疗期间淋巴组织中持续的 HIV 免疫刺激作为持续免疫激活的原因
  • 批准号:
    10376189
  • 财政年份:
    2020
  • 资助金额:
    $ 65.43万
  • 项目类别:
The effect of inflammation and damage to lymph node structures on durable protective immunity following vaccination
炎症和淋巴结结构损伤对疫苗接种后持久保护性免疫力的影响
  • 批准号:
    10091395
  • 财政年份:
    2019
  • 资助金额:
    $ 65.43万
  • 项目类别:
The effect of inflammation and damage to lymph node structures on durable protective immunity following vaccination
炎症和淋巴结结构损伤对疫苗接种后持久保护性免疫力的影响
  • 批准号:
    10584503
  • 财政年份:
    2019
  • 资助金额:
    $ 65.43万
  • 项目类别:
The effect of inflammation and damage to lymph node structures on durable protective immunity following vaccination
炎症和淋巴结结构损伤对疫苗接种后持久保护性免疫力的影响
  • 批准号:
    10335121
  • 财政年份:
    2019
  • 资助金额:
    $ 65.43万
  • 项目类别:
Reservoir Dynamics in Patients Treated in Very Early Acute HIV Infection
极早期急性 HIV 感染患者的储库动态
  • 批准号:
    9305845
  • 财政年份:
    2016
  • 资助金额:
    $ 65.43万
  • 项目类别:
Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV
逆转组织纤维化以改善艾滋病毒的免疫重建
  • 批准号:
    8509163
  • 财政年份:
    2013
  • 资助金额:
    $ 65.43万
  • 项目类别:
Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV
逆转组织纤维化以改善艾滋病毒的免疫重建
  • 批准号:
    8617223
  • 财政年份:
    2013
  • 资助金额:
    $ 65.43万
  • 项目类别:
Tissue Analysis
组织分析
  • 批准号:
    8326441
  • 财政年份:
    2011
  • 资助金额:
    $ 65.43万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 65.43万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了