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Spinal Cord Injury Neuropathic Pain - Identifying Biopsychosocial Predictors

脊髓损伤神经性疼痛 - 识别生物心理社会预测因子

基本信息

批准号：
8848412
负责人：
Elizabeth J Richardson
金额：
$ 3.79万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2015-10-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8848412
关键词：
Acute Address Affective Anxiety Area Biological Process Caring Clinical Clinical Investigator Clinical Research Clinical Treatment Clinical effectiveness Complex Data Development Development Plans Emotions Functional Magnetic Resonance Imaging Functional disorder Goals Health Hydrocortisone Image Individual Injury Inpatients Interview Investigation Lead Life Measures Mentors Methods Modeling Nature Neurologic Outcome Pain Pain Research Persons Physiological Prevention Records Recruitment Activity Refractory Rehabilitation therapy Reporting Research Research Personnel Resolution Rest Salivary Severities Spin Labels Spinal cord injury Stress Structure Techniques Telephone Interviews Testing Training Validation base biological adaptation to stress biopsychosocial career career development clinical application coping data reduction experience gray matter innovation interest meetings morphometry neural circuit neuroimaging novel painful neuropathy primary outcome programs psychologic relating to nervous system resilience response secondary outcome somatosensory spinal cord injury pain standardize measure stress reactivity theories trait

项目摘要

DESCRIPTION (provided by applicant): The candidate's career goal is to become an independent clinical investigator in the biopsychosocial factors of pain following debilitating injuries, particularly identifying novel treatment approaches targeting neuropathic pain (NP) following spinal cord injury (SCI). To meet this goal, the candidate proposes a career development plan with emphasis on training in the biopsychosocial facets of pain, hands-on training using state-of-the-art neuroimaging techniques, and didactics in advanced multivariate statistical approaches, such as high dimensional data reduction that can accommodate the unique challenges presented by pain neuroimaging. A highly accomplished team of investigators with proven track records as mentors will oversee the candidate's career development. The research component of this project addresses two prominent gaps: 1) the field remains limited in its understanding of predictors of neuropathic pain development following SCI and its pathophysiology, and this has precluded successful endeavors to find satisfactory avenues of treatment, and 2) while the biopsychosocial model is hailed as ideal, there has been no study that fully integrates the multiple domains involved in clinical SCI pain research. This proposed project will therefore utilize a combination of psychological, physiological, and neurologic variables to determine which of these factors are associated with the development of SCI-related NP. The aims of the study are to: 1) determine the effects of psychological functioning pre-injury and acutely following SCI on SCI-related NP; 2) identify relationships between neural markers for somatosensory cortical reorganization and SCI-related NP outcomes within two years of SCI; and 3) examine cortical structural and functional resting state measures and determine correlations with SCI-related NP outcomes within two years of SCI. This project will greatly enhance our understanding of the complex biopsychosocial factors involved in the development of NP following SCI, and will provide critical training for Dr. Richardson's development as an independent clinical investigator.

描述（由申请人提供）：候选人的职业目标是成为一名独立的临床研究者，研究衰弱性损伤后疼痛的生物心理社会因素，特别是确定针对脊髓损伤（SCI）后神经性疼痛（NP）的新治疗方法。为了实现这一目标，候选人提出了一个职业发展计划，重点是疼痛的生物心理社会方面的培训，使用最先进的神经成像技术的实践培训，以及先进的多元统计方法的教学，如高维数据简化，可以适应疼痛神经成像带来的独特挑战。一个由经验丰富的调查人员组成的团队将作为导师监督候选人的职业发展。该项目的研究部分解决了两个突出的差距：1)该领域对脊髓损伤后神经性疼痛发展的预测因素及其病理生理学的理解仍然有限，这阻碍了成功寻找令人满意的治疗途径的努力；2)虽然生物心理社会模型被誉为理想的，但尚未有研究完全整合临床脊髓损伤疼痛研究涉及的多个领域。因此，这个拟议的项目将综合运用心理、生理和神经学变量来确定哪些因素与sci相关NP的发展有关。本研究的目的是：1)确定损伤前和损伤后急性期心理功能对脊髓损伤相关NP的影响；2)确定两年内体感觉皮层重组神经标志物与脊髓损伤相关NP结局的关系；3)检查皮层结构和功能静息状态测量，并确定两年内脊髓损伤相关NP结果的相关性。该项目将极大地提高我们对脊髓损伤后NP发展的复杂生物心理社会因素的理解，并将为理查森博士作为独立临床研究者的发展提供重要的培训。