Cell Volume Regulation; Implications for Hydration and Nutrition in Health and Disease

细胞体积调节；

• 批准号: 9124402
• 负责人: Bonnie L. Blazer-Yost
• 金额: $ 3万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9124402
• 关键词: Acute; Address; Affect; American; Apoptosis; Area; Autophagocytosis; Basic Science; Biochemical Process; Biogenesis; Biological Process; Biology; Brain Diseases; Cardiovascular Diseases; Cell Proliferation; Cell Volumes; Cells; Cellular Membrane; Cellular biology; Central Nervous System Diseases; Chicago; Chronic; Collaborations; Communities; Cystic Fibrosis; Data; Diet; Disease; Disease Progression; Electrolytes; Environment; Epithelial; Event; Evolution; Fostering; Goals; Health; Healthcare Systems; Hereditary Disease; High School Student; Homeostasis; Hydration status; Hypertension; Indiana; International; Ion Channel; Ion Transport; Ions; Kidney Diseases; Learning; Letters; Life; Lipids; Liquid substance; Lung diseases; Maintenance; Medicine; Membrane; Molecular; Oils; Oral; Organism; Osmoregulation; Play; Polycystic Kidney Diseases; Population; Postdoctoral Fellow; Process; Regulation; Research Personnel; Role; Science; Scientist; Signal Transduction; Sodium Chloride; Students; Time; Translational Research; United States; Universities; Water; Water Movements; Work; base; cell motility; community college; cost; dietary salt; experience; forging; graduate student; high school; interest; meetings; nervous system disorder; novel; nutrition; outreach; outreach program; professor; programs; salt sensitive; symposium; twelfth grade; university student; uptake; wasting

 DESCRIPTION (provided by applicant): Living organisms necessitate the uptake of energy and of building blocks, and the elimination of waste. Therefore, the barrier that separates them from the environment cannot be completely tight to the movement of water, ions, and small organic molecules. As a consequence, cells from their beginning created basic mechanisms to maintain and regulate their water content and volume. When disrupted, these basic functions can have severe consequences for an organism, and diseases of salt and water transport are involved in both acute and chronic conditions that impact over 50% of the population, and have been documented to cost the health care system billions of dollars annually. The goal of the proposed symposium Cell Biology of Volume Regulation and Fluid Homeostasis, an 11th International Symposium on Cell Volume Regulation is to cover both the basic mechanisms of cell volume regulation and their implications in several major diseases including hypertension, brain disorders and lung and kidney diseases. Specifically, we propose 10 scientific sessions: The first part of the conference Cell Biology of Volume Regulation and Fluid Homeostasis, is divided into 5 sessions: I.1 Molecular Mechanisms of Cell Volume Regulation: Transporters and Ion Channels; I.2 Salt-sensitive Mechanisms in Regulation of Apoptosis and Autophagy; I.3 Cell Volume Regulation in Cell Proliferation and Migration; I.4 Lipid Regulation of Osmotic- and Mechano-sensitive Ion Transport Mechanisms; and I.5 Hydration and water transport through the membrane. The second part of the conference Diseases of Volume Regulation and Fluid Homeostasis, is divided into 4 sessions: II.1 Role of Salt Transport in Hypertension; II.2 Fluid-Electrolyte Contributions to Disease Progression in Polycystic Kidney Disease; II.3 Osmoregulation and Hydration in Cystic Fibrosis; and II.4 Osmoregulation in Neurological and Brain Disorders. A 10th scientific session will be dedicated to Young Investigators. In addition, we propose a new educational outreach initiative that will include high school and community college students. This will be achieved via a "Lunch and Learn with a Professor" sessions that will focus on salt and water in the diet and on small groups discussions about science and scientists personal experiences. It is the first time in the last decade that an International Symposium on Cell Volume Regulation is organized in the United States, which we believe is critically important to facilitate the interaction of the American scientists to the international community and foster international collaborations in this area. Narrative: The major goal of this international scientific meeting on "Cell Volume Regulation and Fluid Homeostasis" is to cover both the basic mechanisms of cell volume regulation and the roles of these mechanisms in several major diseases including hypertension, brain disorders and lung and kidney diseases. In addition, the meeting will include an educational outreach program that will include high school students and community college students to foster the interest of the students to science.

 描述（由适用提供）：活生物体必要的能量和构建基块的吸收以及消除废物。因此，将它们与环境区分开的障碍不能完全紧密与水，离子和小有机分子的运动。结果，细胞从一开始就产生了基本机制来维持和调节其水含量和体积。当被破坏时，这些基本功能可能会对有机体造成严重的后果，盐和水运输疾病涉及影响超过50％人口的急性和慢性病，并已记录在每年损失医疗体系数十亿美元。第11次国际细胞体积调节研讨会的拟议量调节和液体稳态的研讨会生物学的目的是涵盖细胞体积调节的基本机制及其在几种主要疾病，包括高血压，脑部疾病以及肺部和肺部疾病（肺部和肾脏疾病）中的基本机制。具体而言，我们提出了10次科学会议：体积调节和液体稳态的会议细胞生物学的第一部分，分为5个课程：I.1细胞体积调节的分子机制：转运蛋白和离子通道； i.2盐敏感的机制在调节凋亡和自噬中； I.3细胞增殖和迁移中的细胞体积调节； i.4渗透和机械敏感离子传输机制的脂质调节； I.5水合和水通过膜传输。体积调节和液体稳态的会议疾病的第二部分分为4个会议：II.1盐转运在高血压中的作用； II.2多囊性肾脏疾病中疾病进展的流体 - 电解质贡献； II.3囊性纤维化中的渗透调节和水合； II.4神经和脑疾病中的渗透压。第十个科学会议将献给年轻的研究人员。此外，我们提出了一项新的教育外展计划，其中包括高中和社区大学生。这将通过“午餐和与教授学习”会议来实现，该课程将重点介绍饮食中的盐和水以及有关科学和科学家个人经验的小组讨论。这是过去十年中第一次在美国组织国际细胞体积调节研讨会，我们认为这对于促进美国科学家与国际社会的相互作用至关重要，并促进了该领域的国际合作。 叙述：关于“细胞体积调节和液体稳态”的国际科学会议的主要目标是涵盖细胞体积调节的基本机制，以及这些机制在多种主要疾病中的作用，包括高血压，脑部疾病，肺部和肺部和肾脏疾病。此外，会议将包括一个教育外展计划，其中包括高中生和社区大学生，以促进学生对科学的兴趣。