Single round infection chikungunya virus as a new vaccine candidate

单轮感染基孔肯雅病毒作为新候选疫苗

• 批准号: 9110645
• 负责人: ILYA V. FROLOV
• 金额: $ 18.38万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9110645
• 关键词: Adverse reactions; Aedes; Aerosols; Africa; Alphavirus; Antibody Formation; Arthralgia; Asia; Attenuated; Attenuated Vaccines; Basic Science; Biological; Capsid Proteins; Cell Culture Techniques; Cells; Chikungunya virus; Complement; Culicidae; DNA Viruses; Data; Defect; Development; Disease; Disease Outbreaks; Epidemic; Equilibrium; Evolution; Exanthema; Fever; Future; Generations; Genome; German population; Government; Human; Immune; Immune response; Inactivated Vaccines; Infection; International; Island; Licensing; Life; Macaca mulatta; Mus; National Institute of Allergy and Infectious Disease; Pathogenicity; Production; Public Health; Research; Research Institute; Research Project Grants; Residual state; Safety; Staging; Structure; System; Technology; Testing; Therapeutic; Time; Vaccination; Vaccine Design; Vaccine Therapy; Vaccines; Vero Cells; Viremia; Virulent; Virus; Virus Diseases; Virus-like particle; West Indies; base; biodefense; design; effective therapy; human disease; immunogenic; immunogenicity; in vivo; meetings; neutralizing antibody; novel vaccines; particle; pathogen; peace; public health relevance; transmission process; vaccine candidate; vaccine development; vaccine efficacy; vaccine safety; vector; vector mosquito; viral transmission; weapons

 DESCRIPTION (provided by applicant): Chikungunya virus (CHIKV) is an important etiologic agent of human disease. Recently, this virus has moved to Western hemisphere and has developed wide-spread epidemics on the Caribbean Islands with frequent introduction into US. Within one year, from 2013 to 2014, number of cases associated with local transmission increased from one to almost a million, suggesting that we are in the beginning of large outbreak in the New World. Typically, CHIKV causes a severe, self-limited disease characterized by fever, rash and excruciating joint pain. Moreover, the recent epidemics also suggested that CHIKV has become more virulent. Previous CHIKV transmission was associated with Aedes aegypti mosquitoes, but in the recent years, Ae. albopictus became an equally important vector of CHIKV. This mosquito species is common in the US, and future wide spread of CHIKV appears to be just a matter of time. Despite their public health threat as emerging virus and potential for application as biological weapons, no licensed vaccines or therapeutic means have been developed against CHIKV infection. This research project is based on further development of the new concept in vaccine designing. It will result in generation of pseudoinactivated CHIKV (CHIK PIV), which produces only a single round infection in vivo. New CHIKV vaccine candidate will combine the efficiency of live vaccines and safety of inactivated or subunit ones.

 描述（由适用提供）：chikungunya病毒（CHIKV）是人类疾病的重要病因。最近，该病毒已转移到西半球，并在加勒比海岛上开发了广泛的情节，经常引入我们。从2013年到2014年，与本地传播相关的案件的数量在一年之内从一个增加到一百万，这表明我们正处于新世界的大规模爆发之初。通常，CHIKV会引起严重的自限性疾病，其特征是发烧，皮疹和令人发指的关节疼痛。此外，最近的一集还表明，奇克夫变得更加强大。以前的Chikv传播与埃及埃及蚊子有关，但近年来是AE。白化病成为Chikv同样重要的向量。这种蚊子物种在美国很常见，而Chikv的未来广泛传播似乎只是时间问题。尽管它们是新兴病毒的公共卫生威胁，并且有可能用作生物武器，但仍未针对Chikv感染开发出持牌疫苗或治疗手段。该研究项目基于疫苗设计新概念的进一步发展。这将导致伪激活的CHIKV（CHIK PIV）产生，该CHIKV（CHIK PIV）仅在体内产生单一的圆形感染。新的CHIKV疫苗候选者将结合活疫苗的效率和灭活或亚基的安全性。