Nonlinear Computation Tool to Chart Trajectories of Bipolar Disorder

用于绘制双相情感障碍轨迹的非线性计算工具

• 批准号: 9061019
• 负责人: CHARLES LEE BOWDEN
• 金额: $ 64.62万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9061019
• 关键词: Behavioral; Bipolar Depression; Bipolar Disorder; Chaos Theory; Chronic; Chronic Disease; Clinic; Clinical; Clinical Research; Clinical Trials; Cognition; Complex; Computer software; Consent; Data; Data Security; Development; Direct Costs; Disease; Doctor of Medicine; Doctor of Philosophy; Economic Burden; Economics; Effectiveness; Enrollment; Ensure; Facilities and Administrative Costs; Focus Groups; Funding; Goals; Health; Health Care Costs; Health Care Research; Health Insurance Portability and Accountability Act; Health Personnel; Health Professional; Health Sciences; Health Services Accessibility; Healthcare; Improve Access; Individual; Information Resources; Internet; Lead; Manuals; Measures; Methodology; Moods; Morbidity - disease rate; National Institute of Mental Health; Ohio; Online Systems; Operating System; Outcome; Participant; Patients; Performance; Personal Computers; Pharmaceutical Preparations; Phase; Premature Mortality; Principal Investigator; Provider; Psyche structure; Psychiatrist; Public Health; Randomized; Recurrence; Regulation; Reporting; Research Personnel; Risk Behaviors; Role; Sampling; Self Management; Self Perception; Severities; Site; Small Business Technology Transfer Research; Software Engineering; Software Tools; Software Validation; Source; Suggestion; Symptoms; System; Systems Theory; Technology; Testing; Texas; Time; Treatment Efficacy; Universities; Visit; analytical tool; base; biomedical informatics; bipolar patients; commercialization; computerized tools; cost; design; disability; experience; field study; handheld mobile device; health information technology; improved; improved outcome; innovation; mHealth; meetings; mobile application; mood symptom; novel; patient oriented; phase 1 study; phase 2 study; programs; prototype; quality assurance; software development; software systems; success; symptomatic improvement; tool; usability; user centered design

 DESCRIPTION (provided by applicant): Bipolar disorder (BD) is a complex chronic illness characterized by recurrent, often dramatic mood changes. Self-management of BD is an important component of treatment, but is likewise complex and can be fraught with difficulties including misunderstanding of the condition and a lack of self-awareness. Combined with the nationwide shortage of mental healthcare providers and the advent of the Affordable Healthcare Act, patients are assuming an increased role in understanding and managing their chronic conditions. At the same time, the emergence of mobile health and computational tools are engaging patients in self- management by enabling timely access to information and resources. The goal of this project is to complete the development of a patient-centered software system and mobile app to assist in managing bipolar disorder. In Phase I, we developed a novel computational tool known as KIOS. Based on concepts from nonlinear systems (chaos) theory, KIOS tracks multiple interacting symptoms to determine the precise state of a BD patient. Once the patient's state is identified and the trajectory of the patient is established, KIOS produces advice specific to the patient's condition to help manage the course of the disease. To demonstrate the usability of the software, KIOS was converted to an online tool with mobile access. Twenty bipolar patients evaluated KIOS in a twelve week field trial. No technical problems with the software were observed and results showed that patients had significantly more reductions in symptom severity than increases. The development of this innovative tool to help patients self-manage BD has the potential to have a profound impact on public health and achieve significant commercial success. This Phase II study has three Specific Aims: Specific Aim 1. Refine Prototype Software Specific Aim 2. Evaluate KIOS in a Randomized, Open 16 week Effectiveness Study Specific Aim 3. Integrate Data Security and Establish Quality Standards

 描述（由申请人提供）：双相情感障碍（BD）是一种复杂的慢性疾病，其特征是反复发作，经常发生剧烈的情绪变化。BD的自我管理是治疗的重要组成部分，但同样复杂，可能充满困难，包括对病情的误解和缺乏自我意识。再加上全国范围内精神卫生保健提供者的短缺和《平价医疗保健法》的出台，患者在了解和管理其慢性病方面的作用越来越大。与此同时，移动的健康和计算工具的出现通过使患者能够及时访问信息和资源，使患者参与自我管理。本项目的目标是完成以患者为中心的软件系统和移动的应用程序的开发，以帮助管理双相情感障碍。在第一阶段，我们开发了一种新的计算工具，称为KIOS。基于非线性系统（混沌）理论的概念，KIOS跟踪多种相互作用的症状，以确定BD患者的精确状态。一旦确定了患者的状态并建立了患者的轨迹，KIOS就会针对患者的病情提出建议，以帮助管理疾病的进程。为了展示该软件的可用性，KIOS被转换为一个可移动的访问的在线工具。20名双相情感障碍患者在12周现场试验中评价了KIOS。没有观察到软件的技术问题，结果显示患者症状严重程度的降低明显多于增加。开发这种创新工具来帮助患者自我管理BD有可能对公共卫生产生深远的影响，并取得重大的商业成功。本II期研究有三个具体目标：具体目标1。细化原型软件具体目标2.在一项为期16周的随机开放有效性研究中评估KIOS，具体目标3。整合数据安全并建立质量标准

项目成果

Development of a Patient-Centered Software System to Facilitate Effective Management of Bipolar Disorder.

开发以患者为中心的软件系统，以促进双相情感障碍的有效管理。

• 发表时间: 2021
• 期刊: Psychopharmacology bulletin
• 作者: Bowden,CharlesL;Priesmeyer,Richard;Tohen,Mauricio;Singh,Vivek;Calabrese,JosephR;Ketter,Terry;Nierenberg,Andrew;Thase,MichaelE;Siegel,Gregg;Siegel,LeslieH;Mintz,Jim;El-Mallakh,RifS;McElroy,SusanL;Martinez,Melissa
• 通讯作者: Martinez,Melissa