Nonlinear Computation Tool to Chart Trajectories of Bipolar Disorder

用于绘制双相情感障碍轨迹的非线性计算工具

• 批准号: 9061019
• 负责人: CHARLES LEE BOWDEN
• 金额: $ 64.62万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9061019
• 关键词: Behavioral; Bipolar Depression; Bipolar Disorder; Chaos Theory; Chronic; Chronic Disease; Clinic; Clinical; Clinical Research; Clinical Trials; Cognition; Complex; Computer software; Consent; Data; Data Security; Development; Direct Costs; Disease; Doctor of Medicine; Doctor of Philosophy; Economic Burden; Economics; Effectiveness; Enrollment; Ensure; Facilities and Administrative Costs; Focus Groups; Funding; Goals; Health; Health Care Costs; Health Care Research; Health Insurance Portability and Accountability Act; Health Personnel; Health Professional; Health Sciences; Health Services Accessibility; Healthcare; Improve Access; Individual; Information Resources; Internet; Lead; Manuals; Measures; Methodology; Moods; Morbidity - disease rate; National Institute of Mental Health; Ohio; Online Systems; Operating System; Outcome; Participant; Patients; Performance; Personal Computers; Pharmaceutical Preparations; Phase; Premature Mortality; Principal Investigator; Provider; Psyche structure; Psychiatrist; Public Health; Randomized; Recurrence; Regulation; Reporting; Research Personnel; Risk Behaviors; Role; Sampling; Self Management; Self Perception; Severities; Site; Small Business Technology Transfer Research; Software Engineering; Software Tools; Software Validation; Source; Suggestion; Symptoms; System; Systems Theory; Technology; Testing; Texas; Time; Treatment Efficacy; Universities; Visit; analytical tool; base; biomedical informatics; bipolar patients; commercialization; computerized tools; cost; design; disability; experience; field study; handheld mobile device; health information technology; improved; improved outcome; innovation; mHealth; meetings; mobile application; mood symptom; novel; patient oriented; phase 1 study; phase 2 study; programs; prototype; quality assurance; software development; software systems; success; symptomatic improvement; tool; usability; user centered design

 DESCRIPTION (provided by applicant): Bipolar disorder (BD) is a complex chronic illness characterized by recurrent, often dramatic mood changes. Self-management of BD is an important component of treatment, but is likewise complex and can be fraught with difficulties including misunderstanding of the condition and a lack of self-awareness. Combined with the nationwide shortage of mental healthcare providers and the advent of the Affordable Healthcare Act, patients are assuming an increased role in understanding and managing their chronic conditions. At the same time, the emergence of mobile health and computational tools are engaging patients in self- management by enabling timely access to information and resources. The goal of this project is to complete the development of a patient-centered software system and mobile app to assist in managing bipolar disorder. In Phase I, we developed a novel computational tool known as KIOS. Based on concepts from nonlinear systems (chaos) theory, KIOS tracks multiple interacting symptoms to determine the precise state of a BD patient. Once the patient's state is identified and the trajectory of the patient is established, KIOS produces advice specific to the patient's condition to help manage the course of the disease. To demonstrate the usability of the software, KIOS was converted to an online tool with mobile access. Twenty bipolar patients evaluated KIOS in a twelve week field trial. No technical problems with the software were observed and results showed that patients had significantly more reductions in symptom severity than increases. The development of this innovative tool to help patients self-manage BD has the potential to have a profound impact on public health and achieve significant commercial success. This Phase II study has three Specific Aims: Specific Aim 1. Refine Prototype Software Specific Aim 2. Evaluate KIOS in a Randomized, Open 16 week Effectiveness Study Specific Aim 3. Integrate Data Security and Establish Quality Standards



项目成果

Development of a Patient-Centered Software System to Facilitate Effective Management of Bipolar Disorder.

开发以患者为中心的软件系统，以促进双相情感障碍的有效管理。

• 发表时间: 2021
• 期刊: Psychopharmacology bulletin
• 作者: Bowden,CharlesL;Priesmeyer,Richard;Tohen,Mauricio;Singh,Vivek;Calabrese,JosephR;Ketter,Terry;Nierenberg,Andrew;Thase,MichaelE;Siegel,Gregg;Siegel,LeslieH;Mintz,Jim;El-Mallakh,RifS;McElroy,SusanL;Martinez,Melissa
• 通讯作者: Martinez,Melissa