Optimizing Outcomes in Bipolar Illness Interventions in Hispanic Communities

优化西班牙裔社区双相情感障碍干预的结果

• 批准号: 8100769
• 负责人: CHARLES LEE BOWDEN
• 金额: $ 71.57万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8100769
• 关键词: Optimizing; Outcomes; Bipolar; Illness; Interventions

The University of Texas Health Science Center at San Antonio proposes to establish an Advanced Center for Interventions and/or Service Research to conduct research that will personalize community based treatment of bipolar disorders to improve outcomes. We will investigate interactions of cultural factors, adherence and engagement, behavioral domains and biological factors with outcomes, thereby providing a model that can transform current diagnostic and treatment paradigms for bipolar disorder. A major aim of this application is to better develop our understanding of bipolar disorder in the Hispanic American population, in particular the impact of acculturation on adherence to treatment programs. This program will train researchers to work more effectively with this largest U.S. minority population, particularity Mexican Americans who form the majority of Hispanics in the U.S. We will disseminate the knowledge and methodologies we develop to the larger U.S. Hispanic American community, as well as clinicians providing care for persons with bipolar disorder. The studies of the Center will enroll patients who are representative of the full spectrum of patients who receive care in community settings. These projects will contribute to development of more cost effective treatment regimens that are personalized to the characteristics of the patient and weigh tolerability as highly as efficacy. We will develop and promulgate study designs addressing sustained benefit and functional outcomes, sensitive assessments of the fundamental symptom domains in bipolar disorder, and statistical approaches that emphasize patient function. These efforts will be facilitated by our group of nationally recognized leaders in bipolar studies, an experienced scientific staff, the majority of whom are also Hispanic, and national leaders of research on diverse aspects of bipolar disorder. These efforts will equip us to serve as a national resource to advance the NIMH mission of reducing the burden of bipolar illness and improve outcomes through the efforts of research about treatments and their acceptability to patients, and broadly disseminate this research for the purposes of improving clinical care, public education and public health planning.

得克萨斯大学圣安东尼奥大学健康科学中心建议建立一个干预和/或服务研究的高级中心，以进行研究，以个性化基于社区的双相情感障碍治疗以改善结果。我们将研究文化因素，依从性和参与度，行为领域和生物学因素与结果的相互作用，从而提供了一个模型，该模型可以改变当前的诊断和治疗双相情感障碍。该应用的主要目的是更好地发展我们对西班牙裔美国人人口中的双相情感障碍的理解，尤其是文化化对遵守治疗计划的影响。该计划将培训研究人员与美国最大的少数民族人口更有效地合作，墨西哥裔美国人是美国大多数西班牙裔美国人的美国人，我们将传播我们发展给更大的美国西班牙裔美国人社区的知识和方法，以及为患有双极疾病的人提供护理的临床医生。该中心的研究将招募代表在社区环境中接受护理的患者的全部患者。这些项目将有助于开发更具成本效益的治疗方案，这些治疗方案是个性化患者特征的，并使耐受性称为功效。我们将开发和颁布研究设计，以解决持续的好处和功能结果，对躁郁症基本症状结构域的敏感评估以及强调患者功能的统计方法。我们的全国认可的双相研究领导者将促进这些努力，这是一位经验丰富的科学人员，其中大多数也是西班牙裔，以及关于双相情感障碍各个方面的研究领导者。这些努力将使我们能够作为国家资源，以促进NIMH的使命，以减轻双极疾病的负担，并通过对治疗及其对患者的可接受性的研究努力来改善结果，并广泛传播这项研究，以改善临床护理，公共教育和公共卫生计划。