Perfusion MRI for Multi-site Studies of Brain Function

用于脑功能多部位研究的灌注 MRI

• 批准号: 9045707
• 负责人: DAVID Charles ALSOP
• 金额: $ 62.55万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9045707
• 关键词: Achievement; Address; Affect; Alprazolam; Anti-Anxiety Agents; Anxiety; Attention; Biological Markers; Blood; Brain; Brain Diseases; Brain region; Caffeine; Cerebrovascular Circulation; Citalopram; Clinical Research; Communities; Confusion; Coupled; Data; Detection; Development; Diagnosis; Disease; Elements; Emotional disorder; Functional Imaging; Funding; Grant; Health; Image; Image Analysis; Imaging Techniques; Individual; Instruction; Intervention; Intervention Studies; Investigation; Literature; Magnetic Resonance Imaging; Measurement; Measures; Medical; Metabolism; Methodology; Methods; Monitor; Multicenter Studies; Neurologic; Nicotine; Noise; Pathology; Pattern; Performance; Perfusion; Pharmaceutical Preparations; Physiologic pulse; Physiological; Protocols documentation; Reporting; Reproducibility; Research; Research Personnel; Rest; Sample Size; Scanning; Selection for Treatments; Services; Signal Transduction; Site; Source; Spin Labels; Stimulus; Techniques; Technology; Testing; Time; Uncertainty; Variant; Vendor; Work; brain metabolism; design; empowered; experience; image processing; improved; individual patient; mental state; neural correlate; neuroimaging; preference; quality assurance; response; vigilance; volunteer

DESCRIPTION (provided by applicant): Arterial Spin Labeling (ASL) perfusion MRI shows promise as a widely available and quantitative measure of resting brain function that can be used as a biomarker for the neural correlates of psychiatric and neurologic diseases, for the measurement of drug effects in the brain, and ultimately for diagnosis and treatment monitoring in individual patients. Although ASL perfusion MRI technologies are now implemented on most MRI scanner platforms, uncertainty in the community on the performance differences of various technical implementations and how to best use the technology across centers and MRI scanner platforms has limited its dissemination into routine use in clinical research. Building upon our successful development of quantification methods and standard sequences across platforms in the prior funding cycle, we propose to focus on the key issues limiting multi-center studies with ASL. Our first aim is to measure the relative sensitivity of different implementations of ASL by comparing their reproducibility and their response to 2 test interventions, citalopram or alprazolam administration. The result of this aim will be a quantitative calculation of power for detection of regional effects and how the choice of implementation will affect the power and required sample size. The second aim is to develop quality assessment methods using customized image acquisitions and the construction of a perfusion phantom. Quality assurance is a key element of imaging studies across sites, but there are no established methods for testing ASL perfusion performance. In our final aim, we target the characterization and reduction of variable perfusion signal induced by changes in brain activity unrelated to study interventions, so-called physiological noise. We will determine whether performing a moderately demanding vigilance task during the ASL scan will help control the subject's mental state and reduce variability without excessively stimulating particular regions of the brain. We will also study resting fluctuations in perfusion induced by network activity in the brain to determine if identifying and removing these fluctuations during image processing improves reproducibility. This aim will also determine if the amplitude of resting fluctuations is reflective of resting perfusion. Since resting brain fluctuations as measured by blood oxygenation sensitive MRI are increasingly being used as an indicator of resting function, establishing a relationship between fluctuations and average resting activity will address an outstanding question in functional imaging. Achievement of these aims will accelerate and improve the use of ASL as a biomarker for brain function in disease and will greatly improve the design of numerous planned and active multi-site studies employing ASL.

描述（由申请人提供）：动脉自旋标记（ASL）灌注MRI显示出作为静息脑功能的广泛可用和定量测量的前景，可用作精神和神经系统疾病的神经相关性的生物标志物，用于测量大脑中的药物作用，并最终用于个体患者的诊断和治疗监测。尽管ASL灌注MRI技术目前已在大多数MRI扫描仪平台上实现，但社区中对各种技术实现的性能差异以及如何在中心和MRI扫描仪平台之间最佳使用该技术的不确定性限制了其在临床研究中的常规使用中的传播。 在上一个资助周期中成功开发跨平台量化方法和标准序列的基础上，我们建议重点关注限制ASL多中心研究的关键问题。我们的第一个目的是通过比较ASL的再现性和对2种测试干预（西酞普兰或阿普唑仑给药）的反应来测量ASL不同实施方式的相对敏感性。这一目标的结果将是定量计算检测区域效应的功效，以及实施方式的选择将如何影响功效和所需样本量。 第二个目标是开发质量评估方法，使用定制的图像采集和灌注体模的构建。质量保证是各研究中心成像研究的关键要素，但尚未建立检测ASL灌注性能的方法。 在我们的最终目标中，我们的目标是表征和减少与研究干预无关的脑活动变化（所谓的生理噪声）引起的可变灌注信号。我们将确定在ASL扫描期间执行中等要求的警惕任务是否有助于控制受试者的精神状态并减少变异性，而不会过度刺激大脑的特定区域。我们还将研究由大脑中的网络活动引起的灌注的静息波动，以确定在图像处理过程中识别和去除这些波动是否可以提高再现性。该目标还将确定静息波动的幅度是否反映静息灌注。由于通过血氧敏感MRI测量的静息脑波动越来越多地被用作静息功能的指标，因此建立波动和平均静息活动之间的关系将解决功能成像中的一个突出问题。 这些目标的实现将加速和改善ASL作为疾病中脑功能生物标志物的使用，并将大大改善许多计划和积极的多中心研究的设计。