Perfusion MRI for Multi-site Studies of Brain Function

用于脑功能多部位研究的灌注 MRI

• 批准号: 8653375
• 负责人: DAVID Charles ALSOP
• 金额: $ 71.35万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8653375
• 关键词: Achievement; Address; Affect; Alprazolam; Anti-Anxiety Agents; Anxiety; Attention; Biological Markers; Blood; Brain; Brain Diseases; Brain region; Caffeine; Cerebrovascular Circulation; Citalopram; Clinical Research; Communities; Confusion; Coupled; Data; Detection; Development; Diagnosis; Disease; Elements; Emotional disorder; Functional Imaging; Funding; Grant; Image; Image Analysis; Imaging Techniques; Individual; Instruction; Intervention; Intervention Studies; Investigation; Literature; Magnetic Resonance Imaging; Measurement; Measures; Medical; Metabolism; Methodology; Methods; Monitor; Neurologic; Nicotine; Noise; Pathology; Patients; Pattern; Performance; Perfusion; Pharmaceutical Preparations; Physiologic pulse; Physiological; Protocols documentation; Relative (related person); Reporting; Reproducibility; Research; Research Personnel; Rest; Sample Size; Scanning; Selection for Treatments; Services; Signal Transduction; Simulate; Site; Source; Spin Labels; Stimulus; Techniques; Technology; Testing; Time; Uncertainty; Variant; Vendor; Work; brain metabolism; design; empowered; experience; image processing; improved; mental state; neuroimaging; preference; public health relevance; quality assurance; relating to nervous system; response; vigilance; volunteer

Arterial Spin Labeling (ASL) perfusion MRI shows promise as a widely available and quantitative measure of resting brain function that can be used as a biomarker for the neural correlates of psychiatric and neurologic diseases, for the measurement of drug effects in the brain, and ultimately for diagnosis and treatment monitoring in individual patients. Although ASL perfusion MRI technologies are now implemented on most MRI scanner platforms, uncertainty in the community on the performance differences of various technical implementations and how to best use the technology across centers and MRI scanner platforms has limited its dissemination into routine use in clinical research. Building upon our successful development of quantification methods and standard sequences across platforms in the prior funding cycle, we propose to focus on the key issues limiting multi-center studies with ASL. Our first aim is to measure the relative sensitivity of different implementations of ASL by comparing their reproducibility and their response to 2 test interventions, citalopram or alprazolam administration. The result of this aim will be a quantitative calculation of power for detection of regional effects and how the choice of implementation will affect the power and required sample size. The second aim is to develop quality assessment methods using customized image acquisitions and the construction of a perfusion phantom. Quality assurance is a key element of imaging studies across sites, but there are no established methods for testing ASL perfusion performance. In our final aim, we target the characterization and reduction of variable perfusion signal induced by changes in brain activity unrelated to study interventions, so-called physiological noise. We will determine whether performing a moderately demanding vigilance task during the ASL scan will help control the subject's mental state and reduce variability without excessively stimulating particular regions of the brain. We will also study resting fluctuations in perfusion induced by network activity in the brain to determine if identifying and removing these fluctuations during image processing improves reproducibility. This aim will also determine if the amplitude of resting fluctuations is reflective of resting perfusion. Since resting brain fluctuations as measured by blood oxygenation sensitive MRI are increasingly being used as an indicator of resting function, establishing a relationship between fluctuations and average resting activity will address an outstanding question in functional imaging. Achievement of these aims will accelerate and improve the use of ASL as a biomarker for brain function in disease and will greatly improve the design of numerous planned and active multi-site studies employing ASL.

动脉旋转标记 (ASL) 灌注 MRI 显示出作为一种广泛使用的定量方法的前景 静息大脑功能的测量，可用作精神疾病神经相关性的生物标志物 和神经系统疾病，用于测量药物在大脑中的作用，并最终用于诊断 以及个体患者的治疗监测。尽管 ASL 灌注 MRI 技术现在 在大多数 MRI 扫描仪平台上实施，社区对其性能的不确定性 各种技术实施的差异以及如何跨中心和最佳地使用该技术 MRI 扫描仪平台限制了其在临床研究中常规使用的传播。 建立在我们成功开发跨领域的定量方法和标准序列的基础上 在上一个资助周期的平台上，我们建议重点关注限制多中心研究的关键问题 与美国手语。我们的首要目标是通过以下方式衡量 ASL 不同实现的相对敏感性： 比较其再现性及其对 2 种测试干预措施（西酞普兰或阿普唑仑）的反应 行政。这一目标的结果将是对区域检测功率的定量计算。 效果以及实施的选择将如何影响功效和所需的样本量。 第二个目标是使用定制图像采集和开发质量评估方法 灌注模型的构建。质量保证是影像学研究的关键要素 站点，但尚无测试 ASL 灌注性能的既定方法。 在我们的最终目标中，我们的目标是表征和减少由以下因素引起的可变灌注信号： 与研究干预无关的大脑活动变化，即所谓的生理噪音。我们将 确定在 ASL 扫描期间执行中等要求的警戒任务是否有帮助 控制受试者的精神状态并减少变异性，而不会过度刺激特定区域 大脑的。我们还将研究由大脑网络活动引起的静息灌注波动 确定在图像处理过程中识别和消除这些波动是否有所改善 再现性。该目标还将确定静息波动的幅度是否反映了静息波动的幅度。 灌注。由于通过血氧敏感 MRI 测量的静息大脑波动是 越来越多地被用作休息功能的指标，建立了之间的关系 波动和平均静息活动将解决功能成像中的一个突出问题。 这些目标的实现将加速和改善 ASL 作为大脑生物标志物的使用 疾病中的功能，并将极大地改进众多计划中和活跃的多中心研究的设计 使用美国手语。