A 5minute motion-corrected pediatric brain MRI protocol

 描述(申请人提供)：MRI的主要缺点是扫描时间长，在我们机构需要长达一个小时的扫描时间。对于儿童来说，核磁共振可能特别可怕，因为 在嘈杂和受限的空间内长时间扫描可能会增加采集图像中的焦虑和运动伪影的风险。在过度运动的情况下，MRI序列通常是重复的，进一步增加了扫描时间，或者需要患者重新检查MRI套件。另一种选择是使用全身麻醉(GA)，这降低了患者的整体舒适性、安全性、吞吐量，并增加了护理成本。由于这些重大问题，迫切需要一种能够与标准MRI诊断能力相媲美的快速MRI方案。这里的方法将通过使用一系列短轴EPI运动校正MRI方法来克服使用回声平面成像(EPI)进行快速成像的一系列众所周知的问题。我们将基于这些方法开发的5分钟检查将通过具有高诊断质量的快速非镇静脑检查来降低扫描失败率-潜在地导致检测到患者的异常，否则无法通过MRI进行可靠的扫描。通过消除对患者镇静的需求，提高患者舒适度，并将扫描时间减少多达35分钟，我们建议显著提高患者吞吐量、舒适度、降低扫描失败率和医疗保健成本。

 DESCRIPTION (provided by applicant): The main disadvantage of MRI is its long scan time, taking up to one hour at our institution. For children, MRI can be particularly frightening because of long scan times within a noisy and confined space that can increase anxiety and risk of motion artifacts in the acquired images. In cases of excessive motion, MRI sequences are often repeated, further increasing scan time, or requiring patient revisit to the MRI suite. Alternativel, general anesthesia (GA) is used - which reduces the overall patient comfort, safety, throughput, and adding to the cost of care. As a result of these major issues, there is an immediate need for a fast MRI protocol that parallels the diagnostic capacity of the standard MRI. The methods here will overcome a set of well-known problems with the use of fast imaging using Echo Planar Imaging (EPI) through the use of a family of `short axis EPI' motion-correctable MRI methods. The 5minute exam we will develop based on these methods will reduce the scan failure rate through a rapid non-sedated brain exam with high diagnostic quality - potentially leading to detecting abnormalities in patients who otherwise cannot be reliably scanned with MRI. By obviating the need for patient sedation, improving patient comfort and reducing the scan time by up to 35min per patient, we propose to dramatically increase patient throughput, comfort, reduce scan failure rate, and the cost of healthcare.