A 5minute motion-corrected pediatric brain MRI protocol

5 分钟运动校正儿童脑部 MRI 方案

• 批准号: 9112219
• 负责人: Michael E Moseley
• 金额: $ 19.75万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9112219
• 关键词: Acute Brain Injuries; Algorithms; Anxiety; Attenuated; Base of the Brain; Brain; Brain Neoplasms; Brain imaging; Caring; Cerebrospinal Fluid; Child; Childhood; Clinical; Confined Spaces; Coupling; Development; Diagnosis; Diagnostic; Diagnostic tests; Diffusion Magnetic Resonance Imaging; Disadvantaged; Early treatment; Echo-Planar Imaging; Environment; Failure; Family; General Anesthesia; Goals; Gold; Grant; Health Care Costs; Healthcare; Hour; Image; Imaging Techniques; Immune; Institution; Lead; Liquid substance; Magnetic Resonance Imaging; Maps; Methods; Morphologic artifacts; Motion; Outcome; Patients; Plague; Population; Predisposition; Process; Protocols documentation; Recovery; Research; Resolution; Risk; Safety; Scanning; Sedation procedure; Speed; T2 weighted imaging; Testing; Time; Weight; Work; base; compliance behavior; cost; imaging modality; improved; magnetic field; neonate; novel; patient safety; pediatric patients; prototype; public health relevance; reconstruction; volunteer

 DESCRIPTION (provided by applicant): The main disadvantage of MRI is its long scan time, taking up to one hour at our institution. For children, MRI can be particularly frightening because of long scan times within a noisy and confined space that can increase anxiety and risk of motion artifacts in the acquired images. In cases of excessive motion, MRI sequences are often repeated, further increasing scan time, or requiring patient revisit to the MRI suite. Alternativel, general anesthesia (GA) is used - which reduces the overall patient comfort, safety, throughput, and adding to the cost of care. As a result of these major issues, there is an immediate need for a fast MRI protocol that parallels the diagnostic capacity of the standard MRI. The methods here will overcome a set of well-known problems with the use of fast imaging using Echo Planar Imaging (EPI) through the use of a family of `short axis EPI' motion-correctable MRI methods. The 5minute exam we will develop based on these methods will reduce the scan failure rate through a rapid non-sedated brain exam with high diagnostic quality - potentially leading to detecting abnormalities in patients who otherwise cannot be reliably scanned with MRI. By obviating the need for patient sedation, improving patient comfort and reducing the scan time by up to 35min per patient, we propose to dramatically increase patient throughput, comfort, reduce scan failure rate, and the cost of healthcare.

 描述（由申请人提供）：MRI的主要缺点是扫描时间长，在我们的机构需要长达一个小时。对于儿童来说，MRI可能特别可怕，因为 在嘈杂和有限的空间内进行长时间扫描，这可能会增加焦虑和所采集图像中出现运动伪影的风险。在过度运动的情况下，MRI序列通常会重复，进一步增加扫描时间，或需要患者重新访问MRI套件。替代地，使用全身麻醉（GA）-这降低了患者的整体舒适度、安全性、吞吐量，并且增加了护理成本。由于这些主要问题，迫切需要一种与标准MRI诊断能力平行的快速MRI方案。这里的方法将通过使用一系列“短轴EPI”运动可校正的MRI方法克服使用回波平面成像（EPI）的快速成像的一组众所周知的问题。我们将基于这些方法开发的5分钟检查将通过具有高诊断质量的快速非镇静脑部检查来降低扫描失败率-可能导致检测到无法用MRI可靠扫描的患者的异常。通过消除患者镇静的需要、提高患者舒适度并将每位患者的扫描时间减少多达35分钟，我们建议大幅提高患者吞吐量、舒适度、降低扫描失败率和医疗保健成本。