Upgrade of the Stanford GE-Varian Experimental MRI Scanner to the Current Model M

将斯坦福 GE-Varian 实验 MRI 扫描仪升级至当前型号 M

• 批准号: 7793669
• 负责人: Michael E Moseley
• 金额: $ 49.75万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-06 至 2011-10-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793669
• 关键词: Address; Animal Model; Animals; Arts; Biomedical Research; Clinical; Clinical Research; Communities; Detection; Experimental Models; Faculty; Funding; Future; Grant; Healthcare; Housing; Image; Imaging technology; Investments; Magnetic Resonance Imaging; Minor; Modality; Modeling; Molecular Medicine; Monitor; National Center for Research Resources; Physiologic pulse; Play; Public Health; Research; Research Personnel; Resolution; Role; Route; Scanning; Scientist; Stem cells; System; Translational Research; Uncertainty; United States National Institutes of Health; improved; in vivo Cellular and Molecular Imaging Centers; instrumentation; molecular imaging; multimodality; programs; prototype; public health relevance; research study; response; tool

DESCRIPTION (provided by applicant): This proposal is in response to the NCRR "SHARED INSTRUMENTATION PROGRAM S10" (RFA: PAR-09- 028) to reinforce our investment in improved instrumentation for the advancement of biomedical research in Stanford's interdisciplinary programs. Translational biomedical research is of the utmost importance today and with the rapid advances in molecular medicine and stem cells, plays a vital role in the relevance to public health. We are requesting funds for an upgrade of our General Electric Healthcare "MicroSigna" 7 Tesla/310mm animal MRI scanner to the recently-announced GE-Varian product, the MR901. The Stanford 7T MicroSigna was purchased in 2005 from a funded NCRR NIH High-End Shared Instrumentation Grant (1 S10 RR019887-01) entitled "High Field GE Experimental MR Scanner". The existing MicroSigna 7T purchased from the S10 mechanism was in essence a commercial prototype of the now product MR901. The acquisition of the proposed General Electric-Varian MR901 7Tesla High-Field Small-Bore MR scanner upgrade will complete our needs for an MR experimental scanner to support and drive the research of our community of basic and clinical scientists within the multimodality imaging facility, the Stanford Small Animal Imaging Center (SAIC). The SAIC is supported by the Stanford NCRR P41 (Glover, PI), the Stanford Molecular Imaging Program at Stanford (MIPS, Contag, PI), and the Stanford In Vivo Cellular and Molecular Imaging Center (ICMIC, Gambhir, PI). The MR upgrade to be acquired will permit us to better monitor both structural and functional changes in small animal models non-invasively. State of the art MR imaging within the SAIC is necessary to enhance detection sensitivity and resolution; our strong MR-oriented faculty within the P41 has helped us develop new MR applications to support a growing number of crucial biomedical experimental studies now being done on our 3T and 7T whole-body GE Signa LX scanners. The acquisition of this new experimental scanner upgrade will bring the best in clinical consoles (the Signa HDx 20x, multi-coil platform) and all Stanford-derived Signa pulse sequences together into the recently announced GE-Varian MR901 MR scanner commercial product line. The current GE 7T animal scanner (the "MicroSigna") has no doubt enhanced our MR program at Stanford by providing a route for translational research from the top down, that is, by bringing all the MR tools available on clinical research scanners to our routine animal scanning. The upgrade is needed to further improve our imaging technology and bring our MR scanner to a product fully supported by GE and Varian and thus greatly facilitate the introduction of researchers and young investigators to state-of-the-art MR imaging, and also support a strong multi-modality Stanford Small Animal Imaging Facility (SAIC). PUBLIC HEALTH RELEVANCE: This proposal seeks the acquisition of the General Electric-Varian MR901 7Tesla High-Field Small-Bore MR scanner upgrade for the Stanford Small Animal Imaging Facility (SAIC) and the Stanford research community. The current GE 7T animal scanner (the "MicroSigna") housed within the SAIC, while having allowed our many major and minor groups to initiate MR research programs, is limited by several factors which this upgrade will address. The MRI scanner and gradient coil upgrade will permit us to better monitor both structural and functional changes in our various experimental models non-invasively. The upgrade will also bring our MRI scanner to the current commercial product potential necessary for any and all future enhancements. State of the art MR imaging at Stanford is necessary to enhance detection sensitivity and resolution over what we can achieve today on our present system.

描述（由申请人提供）：该提案是对NCRR“共享仪器计划S10”（RFA：PAR-09-028）的回应，以加强我们对斯坦福大学跨学科计划中生物医学研究进步的改进工具的投资。转化生物医学研究至今至关重要，并且随着分子医学和干细胞的迅速发展，在与公共卫生的相关性中起着至关重要的作用。我们要求资金升级我们的通用电气医疗保健“ Microsigna” 7 Tesla/310mm动物MRI扫描仪到最近被宣布的GE-VARAN产品MR901。 Stanford 7T Microsigna于2005年购自资助的NCRR NIH高端共享仪器赠款（1 S10 RR019887-01），名为“高场GE实验性MR SCANNER”。从S10机制购买的现有Microsigna 7T本质上是现在产品MR901的商业原型。对拟议的通用电力魔术MR901的获取7tesla高场小孔MR Scanner升级将满足我们对MR实验扫描仪的需求，以支持和推动我们多模式成像设施中的基本和临床科学家社区的研究，Stanford Small Anluce Imaging Center（SAIC）。 SAIC得到了斯坦福NCRR P41（Glover，pi），斯坦福大学斯坦福分子成像程序（MIPS，MIPS，CONTAG，PI）和体内细胞和分子成像中心（ICMIC，GAMBHIR，PI）的斯坦福大学分子成像程序。获得的MR升级将使我们能够更好地监测小动物模型的结构和功能变化。在SAIC中进行的最新MR成像是为了增强检测灵敏度和分辨率。我们在P41中以MR为导向的强大教师帮助我们开发了新的MR应用，以支持越来越多的重要生物医学实验研究，目前正在我们的3T和7T全身GE Signa LX扫描仪上进行。该新的实验扫描仪升级的获取将使临床控制台（Signa HDX 20X，多线圈平台）和所有斯坦福大学衍生的Signa Pulse Secorces一起将最佳的产品带入最近宣布的GE-VARIAN MR901 MR901 MR SCANNER COMPLIAT PRODECTER LINE。当前的GE 7T动物扫描仪（“ Microsigna”）毫无疑问，通过从上到下提供了一条翻译研究的途径，即通过将所有在临床研究扫描仪上可用的MR工具带入我们的常规动物扫描中，从而增强了我们在斯坦福大学的MR计划。需要进行升级以进一步改进我们的成像技术，并将MR Scanner带到由GE和Varian完全支持的产品中，从而极大地促进了研究人员和年轻研究人员的最先进的MR成像，并支持强大的多模式斯坦福大学斯坦福大学小动物成像设施（SAIC）。 公共卫生相关性：该提案寻求收购普通电力汽车MR901 7TESLA高场小孔Scanner先生升级，以升级斯坦福大学小动物成像设施（SAIC）和斯坦福大学研究界。当前的GE 7T动物扫描仪（“ Microsigna”）包含在SAIC中，同时允许我们的许多主要和次要小组启动MR研究计划，受到该升级将解决的几个因素的限制。 MRI扫描仪和梯度线圈升级将使我们能够在各种实验模型中更好地监测结构和功能变化。升级还将使我们的MRI扫描仪带入当前所有未来增强功能所需的商业产品潜力。在斯坦福大学的MR成像状态对于增强我们今天在当前系统上可以实现的目标的敏感性和解决方案是必要的。

项目成果

Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma.

• DOI: 10.1038/s41598-021-84831-4
• 发表时间: 2021-03-11
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zhou Q;Vega Leonel JCM;Santoso MR;Wilson C;van den Berg NS;Chan CT;Aryal M;Vogel H;Cayrol R;Mandella MJ;Schonig F;Lu G;Gambhir SS;Moseley ME;Rosenthal EL;Grant GA
• 通讯作者: Grant GA

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC).

• DOI: 10.18632/oncotarget.22342
• 发表时间: 2018-01-19
• 期刊: Oncotarget
• 作者: Dhanasekaran R;Gabay-Ryan M;Baylot V;Lai I;Mosley A;Huang X;Zabludoff S;Li J;Kaimal V;Karmali P;Felsher DW
• 通讯作者: Felsher DW