Upgrade of the Stanford GE-Varian Experimental MRI Scanner to the Current Model M

将斯坦福 GE-Varian 实验 MRI 扫描仪升级至当前型号 M

• 批准号: 7793669
• 负责人: Michael E Moseley
• 金额: $ 49.75万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-06 至 2011-10-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793669
• 关键词: Address; Animal Model; Animals; Arts; Biomedical Research; Clinical; Clinical Research; Communities; Detection; Experimental Models; Faculty; Funding; Future; Grant; Healthcare; Housing; Image; Imaging technology; Investments; Magnetic Resonance Imaging; Minor; Modality; Modeling; Molecular Medicine; Monitor; National Center for Research Resources; Physiologic pulse; Play; Public Health; Research; Research Personnel; Resolution; Role; Route; Scanning; Scientist; Stem cells; System; Translational Research; Uncertainty; United States National Institutes of Health; improved; in vivo Cellular and Molecular Imaging Centers; instrumentation; molecular imaging; multimodality; programs; prototype; public health relevance; research study; response; tool

DESCRIPTION (provided by applicant): This proposal is in response to the NCRR "SHARED INSTRUMENTATION PROGRAM S10" (RFA: PAR-09- 028) to reinforce our investment in improved instrumentation for the advancement of biomedical research in Stanford's interdisciplinary programs. Translational biomedical research is of the utmost importance today and with the rapid advances in molecular medicine and stem cells, plays a vital role in the relevance to public health. We are requesting funds for an upgrade of our General Electric Healthcare "MicroSigna" 7 Tesla/310mm animal MRI scanner to the recently-announced GE-Varian product, the MR901. The Stanford 7T MicroSigna was purchased in 2005 from a funded NCRR NIH High-End Shared Instrumentation Grant (1 S10 RR019887-01) entitled "High Field GE Experimental MR Scanner". The existing MicroSigna 7T purchased from the S10 mechanism was in essence a commercial prototype of the now product MR901. The acquisition of the proposed General Electric-Varian MR901 7Tesla High-Field Small-Bore MR scanner upgrade will complete our needs for an MR experimental scanner to support and drive the research of our community of basic and clinical scientists within the multimodality imaging facility, the Stanford Small Animal Imaging Center (SAIC). The SAIC is supported by the Stanford NCRR P41 (Glover, PI), the Stanford Molecular Imaging Program at Stanford (MIPS, Contag, PI), and the Stanford In Vivo Cellular and Molecular Imaging Center (ICMIC, Gambhir, PI). The MR upgrade to be acquired will permit us to better monitor both structural and functional changes in small animal models non-invasively. State of the art MR imaging within the SAIC is necessary to enhance detection sensitivity and resolution; our strong MR-oriented faculty within the P41 has helped us develop new MR applications to support a growing number of crucial biomedical experimental studies now being done on our 3T and 7T whole-body GE Signa LX scanners. The acquisition of this new experimental scanner upgrade will bring the best in clinical consoles (the Signa HDx 20x, multi-coil platform) and all Stanford-derived Signa pulse sequences together into the recently announced GE-Varian MR901 MR scanner commercial product line. The current GE 7T animal scanner (the "MicroSigna") has no doubt enhanced our MR program at Stanford by providing a route for translational research from the top down, that is, by bringing all the MR tools available on clinical research scanners to our routine animal scanning. The upgrade is needed to further improve our imaging technology and bring our MR scanner to a product fully supported by GE and Varian and thus greatly facilitate the introduction of researchers and young investigators to state-of-the-art MR imaging, and also support a strong multi-modality Stanford Small Animal Imaging Facility (SAIC). PUBLIC HEALTH RELEVANCE: This proposal seeks the acquisition of the General Electric-Varian MR901 7Tesla High-Field Small-Bore MR scanner upgrade for the Stanford Small Animal Imaging Facility (SAIC) and the Stanford research community. The current GE 7T animal scanner (the "MicroSigna") housed within the SAIC, while having allowed our many major and minor groups to initiate MR research programs, is limited by several factors which this upgrade will address. The MRI scanner and gradient coil upgrade will permit us to better monitor both structural and functional changes in our various experimental models non-invasively. The upgrade will also bring our MRI scanner to the current commercial product potential necessary for any and all future enhancements. State of the art MR imaging at Stanford is necessary to enhance detection sensitivity and resolution over what we can achieve today on our present system.

描述(由申请人提供)：本提案是对NCRR“共享仪器计划S10”(RFA：PAR-09-028)的响应，旨在加强我们对改进仪器设备的投资，以促进斯坦福大学跨学科项目中的生物医学研究。翻译生物医学研究在当今至关重要，随着分子医学和干细胞的快速发展，在与公共卫生相关的问题上发挥着至关重要的作用。我们正在申请资金，将我们的通用电气医疗保健“MicroSigna”7特斯拉/310 mm动物磁共振扫描仪升级到最近宣布的GE-VARIAN产品MR901。斯坦福7T MicroSigna是2005年从NCRR NIH高端共享仪器基金(1 S10 RR019887-01)购买的，标题为“高场GE实验磁共振扫描仪”。从S10机制购买的现有MicroSigna 7T实质上是现在产品MR901的商业原型。收购拟议中的通用电气-瓦里安MR901 7Tesla高场小口径磁共振扫描仪升级将完成我们对MR实验扫描仪的需求，以支持和推动我们的基础和临床科学家社区在多模成像设施-斯坦福小动物成像中心(SAIC)内的研究。SAIC得到了斯坦福NCRR P41(格洛弗，PI)、斯坦福分子成像计划(MIPS，Contag，PI)和斯坦福活体细胞和分子成像中心(ICMIC，Gambhir，PI)的支持。即将获得的MR升级将使我们能够更好地非侵入性地监测小动物模型的结构和功能变化。SAIC内部最先进的MR成像对于提高检测灵敏度和分辨率是必要的；我们在P41中强大的面向MR的能力帮助我们开发了新的MR应用程序，以支持越来越多的关键生物医学实验研究，这些实验研究目前正在我们的3T和7T GE Signa LX全身扫描仪上进行。收购这一新的实验性扫描仪升级将把临床上最好的控制台(Signa HDX 20x，多线圈平台)和所有来自斯坦福大学的Signa脉冲序列整合到最近宣布的GE-Varian MR901磁共振扫描仪商业产品线中。目前的GE 7T动物扫描仪(“MicroSigna”)无疑增强了我们在斯坦福大学的MR项目，为自上而下的翻译研究提供了一条途径，即将临床研究扫描仪上可用的所有MR工具应用到我们的常规动物扫描中。此次升级是为了进一步改进我们的成像技术，使我们的磁共振扫描仪成为GE和瓦里安完全支持的产品，从而极大地促进研究人员和年轻研究人员接触最先进的磁共振成像，并支持强大的多模式斯坦福小动物成像设备(SAIC)。 公共卫生相关性：这项提案寻求为斯坦福小动物成像设施(SAIC)和斯坦福研究社区购买通用电气-瓦里安MR901 7Tesla高场小口径磁共振扫描仪升级。目前安装在上汽集团内部的GE 7T动物扫描仪(“MicroSigna”)，虽然允许我们的许多大小团体启动磁共振研究计划，但受到此次升级将解决的几个因素的限制。MRI扫描仪和梯度线圈的升级将使我们能够更好地非侵入性地监测我们各种实验模型的结构和功能变化。此次升级还将使我们的核磁共振扫描仪达到目前的商业产品潜力，这是任何和所有未来增强所必需的。斯坦福大学最先进的磁共振成像是必要的，以提高检测的灵敏度和分辨率，而不是我们目前的系统所能实现的。

项目成果

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC).

• DOI: 10.18632/oncotarget.22342
• 发表时间: 2018-01-19
• 期刊: Oncotarget
• 作者: Dhanasekaran R;Gabay-Ryan M;Baylot V;Lai I;Mosley A;Huang X;Zabludoff S;Li J;Kaimal V;Karmali P;Felsher DW
• 通讯作者: Felsher DW

Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma.

• DOI: 10.1038/s41598-021-84831-4
• 发表时间: 2021-03-11
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zhou Q;Vega Leonel JCM;Santoso MR;Wilson C;van den Berg NS;Chan CT;Aryal M;Vogel H;Cayrol R;Mandella MJ;Schonig F;Lu G;Gambhir SS;Moseley ME;Rosenthal EL;Grant GA
• 通讯作者: Grant GA