NONGAUSSIAN DIFFUSION BEHAVIOR IN BRAIN

大脑中的非高斯扩散行为

• 批准号: 7358744
• 负责人: Michael E Moseley
• 金额: $ 2.49万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358744
• 关键词: NONGAUSSIAN; DIFFUSION; BEHAVIOR; BRAIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to develop models of non-random diffusion in the human body using diffusion tensor imaging (DTI) for the investigators and collaborators on the P41 RR09784 ?Center for Advanced MR Technology at Stanford? effort. Studies using high levels of diffusion sensitization (b 2000 sec/mm2) appear to indicate that the ADC has separate components, producing a non-monoexponential signal decay with diffusion sensitization at the higher b values. Studies of proton diffusion at high b values, however, may provide tissue contrast from a ?slower? ADC component (of the biexponential model) that may more relevant to the expanding intracellular compartment (also seen as cytotoxic edema), since it may be in exchange with the ?fast? ADC water population. Upon modeling this, we find that this occurs mostly in white matter where fibers may be crossing, producing non-random diffusion. A faster ADC component dominates at low b values, while at higher b-values, a second, slower ADC component becomes apparent. It is striking to note the large differences and the lack of any observable slow FA tissue contrast. We have finished all anticipated work on this effort and have submitted these results as a published abstract supporting our models.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目标是利用扩散张量成像(DTI)为斯坦福大学P41 RR09784高级磁共振技术中心的研究人员和合作者建立人体内非随机扩散的模型。努力。使用高扩散敏化水平(b 2000秒/mm2)的研究似乎表明，ADC有单独的分量，在较高的b值处产生非单指数信号衰减和扩散敏化。然而，对高b值质子扩散的研究可能会提供较慢的组织对比度。ADC成分(双指数模型)，可能与扩张的细胞内隔室(也被视为细胞毒性水肿)更相关，因为它可能与FAST？ADC水人口。在对此进行建模后，我们发现这主要发生在纤维可能交叉的白质中，产生非随机扩散。在低b值时，较快的ADC分量占主导地位，而在较高的b值时，第二个较慢的ADC分量变得明显。这是惊人的注意到巨大的差异和缺乏任何可观察到的缓慢FA组织对比。我们已经完成了这项工作的所有预期工作，并将这些结果作为支持我们模型的出版摘要提交。