Reprogramming of Prostate Stromal Cells by Prostate Inflammation
前列腺炎症对前列腺基质细胞的重编程
基本信息
- 批准号:9098081
- 负责人:
- 金额:$ 22.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-04-01 至 2018-03-31
- 项目状态:已结题
- 来源:
- 关键词:Acute ProstatitisAdultAffectApplications GrantsBacteriaBacterial InfectionsBasal CellBasement membraneBiologicalBiological AssayCandidate Disease GeneCell Differentiation processCell physiologyCellsClinicalComplementDiseaseEnvironmentEpithelial CellsIndolentInfectionInflammationInflammatoryLeadMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of prostateMediatingMedical Care CostsMesenchymalMicroarray AnalysisModelingMolecularMusNatural regenerationPlayPrognostic MarkerProstateProstatic NeoplasmsRegulationRoleSignal TransductionStromal CellsTestingTissue MicroarrayTumor Cell InvasionUrogenital Sinusbasecell typefetalgenetic approachimprovedmortalitymouse modelnovelprognosticprogramsprostatitispublic health relevancetranscriptometranscriptome sequencingtumor
项目摘要
DESCRIPTION (provided by applicant): Basal and luminal cells are the two major types of epithelial cells in the prostate. These two types of cells are mostly independently sustained in adults and both can serve as the cells of origin for prostate cancer. Recent studies using mouse models revealed that prostate cancer originated from basal epithelial cells are more invasive than those derived from luminal cells. Interestingly, initiation of this invasive type of prostate cancer is limited by a cellular process called basal-to-luminal differentiation. We showed recently that basal-to-luminal differentiation is enhanced in the context of prostatitis induced by
infection from uropathogenic bacteria, suggesting that prostate stromal microenvironment substantially impinge on the differentiation program of prostate basal epithelial cells. In this application, we propose to use a combination of molecular biological and genetic approaches to uncover how the bacterial infection induced prostatitis affects prostate stromal cell transcriptome. We seek to identify prostate stromal cell-mediated signaling that plays critical roles in regulation of basal epithelial cell differentiation, and verify whether they serve as prognostic markers for aggressive prostate cancer.
描述(由申请人提供):基底细胞和腔细胞是前列腺中两种主要类型的上皮细胞。这两种类型的细胞在成年人中大多独立存在,两者都可以作为前列腺癌的起源细胞。最近使用小鼠模型的研究表明,起源于基底上皮细胞的前列腺癌比起源于管腔细胞的前列腺癌更具侵袭性。有趣的是,这种侵袭性类型的前列腺癌的发生受到称为基底细胞向管腔细胞分化的细胞过程的限制。我们最近发现,在前列腺炎诱导的背景下,基底细胞到管腔的分化增强,
来自尿路病原菌感染,表明前列腺基质微环境实质上影响前列腺基底上皮细胞的分化程序。在本申请中,我们建议使用分子生物学和遗传学方法的组合来揭示细菌感染诱导的前列腺炎如何影响前列腺基质细胞转录组。我们试图确定前列腺基质细胞介导的信号传导,在调节基底上皮细胞分化中发挥关键作用,并验证它们是否作为侵袭性前列腺癌的预后标志物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Li Xin其他文献
Dynamic scheduling of photolithography process based on Kohonen neural network
基于Kohonen神经网络的光刻工艺动态调度
- DOI:
10.1007/s10845-013-0763-9 - 发表时间:
2013-04 - 期刊:
- 影响因子:8.3
- 作者:
ZHOU Bing-hai;Li Xin;Richard Y. K. FUNG - 通讯作者:
Richard Y. K. FUNG
Li Xin的其他文献
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{{ truncateString('Li Xin', 18)}}的其他基金
Support for the 2023 Society of Basic Urological Diseases annual meeting
支持2023年泌尿基础病学会年会
- 批准号:
10748948 - 财政年份:2023
- 资助金额:
$ 22.23万 - 项目类别:
Stromal Foxf2 suppresses prostate cancer progression
基质 Foxf2 抑制前列腺癌进展
- 批准号:
10461677 - 财政年份:2022
- 资助金额:
$ 22.23万 - 项目类别:
Stromal Foxf2 suppresses prostate cancer progression
基质 Foxf2 抑制前列腺癌进展
- 批准号:
10643864 - 财政年份:2022
- 资助金额:
$ 22.23万 - 项目类别:
Molecular mechanisms of initiation of benign prostatic hyperplasia
良性前列腺增生起始的分子机制
- 批准号:
10398260 - 财政年份:2016
- 资助金额:
$ 22.23万 - 项目类别:
Molecular Mechanisms of Initiation of Benign Prostatic Hyperplasia
良性前列腺增生发生的分子机制
- 批准号:
9201326 - 财政年份:2016
- 资助金额:
$ 22.23万 - 项目类别:
Reprogramming of Prostate Stromal Cells by Prostate Inflammation
前列腺炎症对前列腺基质细胞的重编程
- 批准号:
9247932 - 财政年份:2016
- 资助金额:
$ 22.23万 - 项目类别:
Molecular mechanisms of initiation of benign prostatic hyperplasia
良性前列腺增生起始的分子机制
- 批准号:
10625982 - 财政年份:2016
- 资助金额:
$ 22.23万 - 项目类别:
Molecular mechanisms of initiation of benign prostatic hyperplasia
良性前列腺增生起始的分子机制
- 批准号:
9883608 - 财政年份:2016
- 资助金额:
$ 22.23万 - 项目类别:
The Notch Signaling in Prostate Homeostasis and Carcinogenesis
前列腺稳态和癌发生中的Notch信号传导
- 批准号:
8958462 - 财政年份:2015
- 资助金额:
$ 22.23万 - 项目类别:
The Notch Signaling in Prostate Homeostasis and Carcinogenesis
前列腺稳态和癌发生中的Notch信号传导
- 批准号:
9107395 - 财政年份:2015
- 资助金额:
$ 22.23万 - 项目类别:
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