The role of coherent angular motion in adult tissue remodeling

相干角运动在成人组织重塑中的作用

• 批准号: 9343925
• 负责人: Kandice Tanner
• 金额: $ 32.63万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9343925
• 关键词: Acinus organ component; Actins; Actomyosin; Adult; Affect; Alveolus; Apical; Architecture; Behavior; Biological Assay; Biophysics; Biotechnology; Breast; Breast Epithelial Cells; Cells; Cellular biology; Confocal Microscopy; Development; Drug resistance; Environment; Epithelial; Extracellular Matrix; Functional disorder; Geometry; Goals; Human; Image; Imagery; Laminin; Lead; Life; Maintenance; Malignant - descriptor; Malignant Neoplasms; Membrane; Microscopy; Modeling; Molecular; Motion; Movement; Neoplasm Metastasis; Non-Malignant; Normal Cell; Organ; Pathologic; Pathway interactions; Process; Property; Resolution; Role; Rotation; Staging; Structure; Surface; Therapeutic; Time; Tissues; cancer cell; cancer therapy; design; genetic information; imaging platform; in vivo; novel; polymerization; research study; tumor

The goal is to integrate concepts from molecular biophysics and cell biology to understand how cells and tissues sense and respond to their physical microenvironment and to exploit these principles for the design of effective therapeutics and cellular biotechnology. It is expected that these microscopy studies will create a new understanding of how normal and cancer cells are affected by their micro-environments, leading to new cancer therapies and new concepts in understanding malignancy, metastasis, and drug resistance.

目标是整合分子生物物理学和细胞生物学的概念，以了解细胞和组织如何感知和响应其物理微环境，并利用这些原理设计有效的治疗方法和细胞生物技术。预计这些显微镜研究将对正常细胞和癌细胞如何受到其微环境的影响产生新的理解，从而产生新的癌症治疗方法和理解恶性肿瘤，转移和耐药性的新概念。