Synthetic bacteria as a targeted delivery system for small molecule therapeutics
Synthetic bacteria as a targeted delivery system for small molecule therapeutics
批准号:
10487051
负责人:
Kandice Tanner
金额:
$16.94万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AdjuvantAntigensBacteremiaBacteriaBacterial SporesBasic ScienceCancer VaccinesDrug Delivery SystemsERBB2 geneEpitopesImageIn VitroInterferon Type IIMalignant NeoplasmsMetastatic malignant neoplasm to brainModelingMusPeptidesPhospholipidsProductionProteinsReportingReproduction sporesResearchSilicon DioxideStaphylococcus aureus infectionSystemT memory cellTestingTherapeuticThickTranslationsVaccinesXenograft ModelZebrafishcancer cellcell typeefficacy testinginterestmouse modelparticleprotective efficacyreconstitutionsmall moleculesmall molecule therapeuticssynthetic constructtargeted deliverytumortumor xenograft
中文摘要
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英文摘要
Recently, we have tested the efficacy of a vaccine against the bacterium Staphyloccocus aureus when displayed on SSHELs. We discovered that SSHEL-displayed vaccine enhanced the protective efficacy against S. aureus infection in a mouse bacteremia model without the need for an adjuvant, compared to administration of the vaccine alone, and that this was likely via increased production of memory T cells producing TNFalpha and IFN gamma. The project represents the translation of basic science research developed in the Ramamurthi lab, and employs the imaging and zebrafish tumor model expertise in the Tanner lab, and the vaccine, drug delivery, and mouse model expertise in the Fitzgerald lab.
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