Enhancement and Expansion: Penn Neurophysiology and Behavior Testing Facility

增强和扩展：宾夕法尼亚大学神经生理学和行为测试设施

• 批准号: 9120117
• 负责人: Stuart N. Isaacs
• 金额: $ 49.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120117
• 关键词: Acclimatization; Affect; Animal Welfare; Animals; Area; Basic Science; Behavior; Behavioral; Biological Models; Brain; Cognition; Complex; Decision Making; Food; Funding; Goals; Health; Housing; Human; Institution; Longevity; Measurement; Neurodevelopmental Disorder; Occupational; Pennsylvania; Perception; Personal Satisfaction; Primates; Productivity; Quarantine; Research; Research Personnel; Residencies; Resolution; Safety; Socialization; Stress; Time; Translational Research; Universities; Work; base; behavior test; cost; environmental enrichment for laboratory animals; food preparation; guide for the care and use of laboratory animals; improved; meetings; neurophysiology; neuropsychiatric disorder; nonhuman primate; programs; social; translational study

 DESCRIPTION (provided by applicant): Non-human primates (NHPs) occupy a vital niche in basic and translational studies of higher brain function, representing a model system that allows for direct, high-resolution measurements and manipulations of brain mechanisms in the context of complex behaviors. At a time when other institutions are downsizing NHP research because of cost and other constraints, the University of Pennsylvania (Penn) is making a strong, lasting commitment to this research. The overall goal of this proposal is to improve animal welfare and occupational human health, with the added simultaneous benefit of accelerating basic and translation research in neurodevelopmental and neuropsychiatric disorders that affect high-level brain function. This is accomplished by creating a shared NHP Neurophysiology and Behavior Facility (NHP-NBF) that will provide enhanced group socialization enrichment, food enrichment, quarantine, and housing areas. Work in the NHP- NBF will coalesce multiple well-funded investigators with complementary research programs that examine high-level functions of the primate brain, including perception, cognition, action and decision-making. Importantly, G20 renovation support will substantially enhance animal welfare at Penn by providing: (1) a dedicated socialization enrichment room; (2) a dedicated food preparation area for the primate environmental enrichment program; (3) a dedicated NHP quarantine room that will allow coordinated importation and acclimation of animals and improve safety for staff and NHPs; and (4) an additional housing room to decompress current housing rooms, thereby enhancing staff safety and to help meet the capacity demand of funded research. The G20-funded enhancements in the enrichment program are particularly important for the NHPs in the facility because, unlike animals involved in many other types of research, many of the NHPs have very long residencies in the facility and are expected to perform challenging behavioral tasks on a regular basis. Reducing stress and improving the overall well-being of NHPs via enhanced social and food enrichment programs provide substantial value to the animals and to Penn's research programs by increasing the animal's health, longevity, and productivity. The renovated areas will meet or exceed modern requirements, as stated in the Guide for the Care and Use of Laboratory Animals (ILAR, 2011) and as interpreted by AAALAC, the USDA and OLAW, and is complementary to an overall building project that will reduce energy utilization.

 描述（由申请人提供）：非人类灵长类动物（NHP）在高级大脑功能的基础和转化研究中占据着重要地位，代表了一个模型系统，允许在复杂行为的背景下直接、高分辨率测量和操纵大脑机制。当其他机构因成本和其他限制而缩减 NHP 研究规模时，宾夕法尼亚大学 (Penn) 却对这项研究做出了坚定而持久的承诺。该提案的总体目标是改善动物福利和人类职业健康，同时加速影响高级大脑功能的神经发育和神经精神疾病的基础和转化研究。这是通过创建一个共享的 NHP 神经生理学和行为设施 (NHP-NBF) 来实现的，该设施将提供增强的团体社交丰富、食物丰富、检疫和住房区域。 NHP-NBF 的工作将联合多个资金充足的研究人员和互补的研究项目，检查灵长类大脑的高级功能，包括感知、认知、行动和决策。重要的是，G20 翻修支持将通过提供以下内容大幅提高宾夕法尼亚大学的动物福利：(1) 专门的社交强化室； (2) 灵长类环境丰富计划专用食物准备区； (3) 专门的 NHP 检疫室，可协调动物的进口和驯化，并提高工作人员和 NHP 的安全； (4) 额外的住房空间，以减轻现有住房的压力，从而提高工作人员的安全并有助于满足资助研究的容量需求。 G20 资助的强化项目对于该设施中的 NHP 尤其重要，因为与参与许多其他类型研究的动物不同，许多 NHP 在该设施中居住了很长时间，并且预计会定期执行具有挑战性的行为任务。通过加强社会和食物丰富计划来减轻 NHP 的压力并改善其整体福祉，通过提高动物的健康、寿命和生产力，为动物和宾夕法尼亚大学的研究项目提供巨大的价值。翻新后的区域将满足或超过实验动物护理和使用指南（ILAR，2011）中所述以及 AAALAC、USDA 和 OLAW 的解释的现代要求，并且是对减少能源利用的整体建筑项目的补充。