Pathophysiology of the cartliage growh plate

软骨生长板的病理生理学

• 批准号: nhmrc : 491207
• 负责人: Prof John Bateman
• 金额: $ 32.41万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathophysiology-cartliage-growh-plate/78003
• 关键词: Pathophysiology; cartliage; growh; plate

The principle objective of the proposed project is to determine the molecular, cellular extracellular matrix pathology of chondrodysplasia phenotypes which result from mutations in a variety of different gene products that are important for normal bone development. To achieve our objective the Eurogrow consortium has developed an extensive series of mouse models of chondrodysplasias that closely mimic the relevant human phenotype. The consortium will use a multidisciplinary systems biology approach to determine the molecular mechanisms that underpin the pathophysiology of these distinct chondrodysplasias. From this approach we can expect to identify common disease mechanisms and learn general principles about genotype-phenotype correlations in chondrodysplasia phenotypes. The NHMRC-EU grant is to fund a consortium (Eurogrow) of 10 EU research groups (led by the University of Manchester) along with my research group at the MCRI to conduct these integrated studies.

该项目的主要目标是确定软骨发育不良表型的分子、细胞外基质病理，这些表型是由对正常骨骼发育至关重要的各种不同基因产物的突变引起的。为了实现我们的目标，欧洲生长联盟开发了一系列广泛的软骨发育不良小鼠模型，这些模型非常接近于相关的人类表型。该联盟将使用多学科系统生物学方法来确定支撑这些不同软骨发育不良病理生理学的分子机制。通过这种方法，我们可以期望确定常见的疾病机制，并了解有关软骨发育不良表型中的基因-表型相关性的一般原则。NHMRC-EU拨款是为了资助一个由10个欧盟研究小组(由曼彻斯特大学领导)组成的联盟(EuroGrowth)，以及我在MCRI的研究小组，以进行这些综合研究。