Across-Site Patterns of Cochlear Implant Function: Importance of Cochlear Health

人工耳蜗功能的跨部位模式：耳蜗健康的重要性

• 批准号: 9210756
• 负责人: BRYAN E PFINGST
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-05 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9210756
• 关键词: Affect; Animal Model; Animals; Auricular prosthesis; Bilateral; Biological; Biology; Cavia; Characteristics; Clinical; Cochlea; Cochlear Implants; Communication; Data; Detection; Dexamethasone; Ear; Electric Stimulation; Electrodes; Electrophysiology (science); Growth; Health; Hearing; Hearing Impaired Persons; Human; Implant; Implanted Electrodes; Individual; Measurement; Measures; Modiolus; Neurons; Pathology; Patients; Pattern; Performance; Peripheral; Physiologic pulse; Procedures; Process; Prosthesis; Psychophysics; Rehabilitation therapy; Research; Residual state; Role; Scala Tympani; Series; Site; Speech; Stimulus; Surgeon; Testing; Time; Tissue Engineering; Tissue Preservation; Training; Variant; Work; animal data; base; clinical Diagnosis; clinically relevant; density; experience; human subject; implantation; improved; individual patient; insight; myelination; relating to nervous system; research study; response; speech recognition; spiral ganglion; tool

 DESCRIPTION (provided by applicant): The objectives of our research are (1) to determine how the health of the implanted cochlea, i.e. the biological conditions near the individual cochlear-implant electrodes, affects specific psychophysical and electrophysiological measures of electrical hearing; (2) to determine the relationships of these specific measures to speech recognition with the cochlear prosthesis; and (3) to use this information to increase the benefit that hearing impaired patients receive from their prostheses. The data from these studies can be used in two ways to improve speech recognition in cochlear implant users. First, based on animal work that will correlate the pattern of pathology with functional measures, we will provide audiologists with simple clinically applicable measures they can use to gain insight into the characteristics of the individual patient's cochlea and better identify and select the best stimulation sites for an individual patient's speech processor MAP. Second the data can help the biologist and the surgeon to determine the best anatomical targets for improving implant function through tissue-preservation and tissue-engineering strategies to make the impaired cochlea more receptive to cochlear implant stimulation. Our approach involves psychophysical and electrophysiological experiments in guinea pigs as well as psychophysical, electrophysiological and speech recognition studies in humans. We measure psychophysical performance, such as perceptual integration of pulse trains, and electrophysiological performance such as the rate at which evoked neural responses grow as a function of stimulus level. These measurements are made at individual stimulation sites in guinea pigs and humans. In guinea pigs we determine the specific anatomical features in the deaf or hearing-impaired cochlea that are correlated with these measures. In humans we determine the correlation of these same measures with speech recognition in quiet and in noisy backgrounds. We can then use these measures in humans to select the best stimulation sites for an individual subject's speech processor. This approach is supported by our previous studies showing that subjects usually perform better using a processor MAP with a subset of stimulation sites, carefully selected using appropriate functional measures, than they do with a processor that uses all available sites. The work proposed in this application will deepen our understanding of the mechanisms underlying variation in speech recognition performance across users of cochlear implants and serve as a guide for establishing and testing clinical procedures that will improve performance in individual patients.