Deorphanization of Schistosome Cytochrome P450

 描述（由申请人提供）：该 R21 探索性/开发研究提案的目标是确定曼氏血吸虫（血吸虫病的病原体）中存在的唯一细胞色素 P450 蛋白的功能。我们假设独特的血吸虫细胞色素 P450 对于线虫的交流、生存、繁殖和发育至关重要，并且可以通过将其与特定的代谢途径联系起来来识别其功能。我们相信，了解这种蛋白质的功能将确定关键的信号传导途径，并将有助于发现治疗血吸虫病的新药。血吸虫病是一种重要的、被忽视的疾病，有超过 2 亿人感染，每年导致 20 万人死亡，以及无数的慢性疾病和残疾。只有一种药物可用于治疗血吸虫病，并且人们担心耐药性正在演变。

 DESCRIPTION (provided by applicant): The goal of this R21 Exploratory/Developmental Research proposal is to identify the function of the only cytochrome P450 protein present in Schistosoma mansoni, a causative agent of schistosomiasis. We hypothesize that the unique schistosome cytochrome P450 is essential for worm communication, survival, reproduction, and development and that its function can be identified by linking it to specific metabolic pathways. We believe that understanding the function of this protein will identify critical signaling pathway and will be useful in the discovery of new drugs for schistosomiasis, an important, neglected disease with more than 200 million people infected resulting in 200,000 deaths annually and untold chronic illness and disability. Only one drug is available for schistosomiasis treatment and there are concerns that drug resistance is evolving.