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Deorphanization of Schistosome Cytochrome P450

血吸虫细胞色素 P450 的脱孤儿化

基本信息

批准号：
9035124
负责人：
DAVID LEE WILLIAMS
金额：
$ 23.25万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-15 至 2018-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9035124
关键词：
Accounting Adult Animals Antifungal Agents Arachidonic Acids Azoles Catabolism Cell membrane Cells Cessation of life Cholesterol Chronic Disease Clinical Communication Critiques Cytochrome P450 Data Detoxification Process Development Disease Drug Metabolic Detoxication Drug Targeting Drug resistance Ecdysteroids Eicosanoids Enzymes Ergosterol Escherichia coli Family Foundations Fungal Components Genes Genome Goals Hormones Human Imidazole Infection Insecta Investigation Label Lead Link Lipids Messenger RNA Metabolic Pathway Miconazole Molecular Target Orphan Parasites Pharmaceutical Preparations Pharmacology Pharmacotherapy Poison Polyunsaturated Fatty Acids Praziquantel Praziquantel resistance Production Proteins RNA Interference Recombinant Proteins Recombinants Reproduction Research Proposals Retinoids Schistosoma Schistosoma mansoni Schistosomiasis Secosteroids Signal Pathway Signaling Molecule Staging Structure-Activity Relationship Testing Vitamin A Vitamin D Xenobiotics Yeasts analog chemotherapy design disability drug development enzyme pathway evidence base improved inhibitor/antagonist metabolomics neglect novel therapeutics protein function public health relevance scaffold screening steroid hormone

项目摘要

DESCRIPTION (provided by applicant): The goal of this R21 Exploratory/Developmental Research proposal is to identify the function of the only cytochrome P450 protein present in Schistosoma mansoni, a causative agent of schistosomiasis. We hypothesize that the unique schistosome cytochrome P450 is essential for worm communication, survival, reproduction, and development and that its function can be identified by linking it to specific metabolic pathways. We believe that understanding the function of this protein will identify critical signaling pathway and will be useful in the discovery of new drugs for schistosomiasis, an important, neglected disease with more than 200 million people infected resulting in 200,000 deaths annually and untold chronic illness and disability. Only one drug is available for schistosomiasis treatment and there are concerns that drug resistance is evolving.

描述（由申请人提供）：本R21探索性/开发性研究提案的目标是鉴定曼氏血吸虫（血吸虫病的病原体）中存在的唯一细胞色素P450蛋白的功能。我们假设，独特的双质体细胞色素P450是必不可少的蠕虫通信，生存，繁殖和发展，其功能可以通过将其连接到特定的代谢途径来确定。我们相信，了解这种蛋白质的功能将确定关键的信号通路，并将有助于发现新的血吸虫病药物，血吸虫病是一种重要的，被忽视的疾病，每年有超过2亿人感染，导致20万人死亡和无数的慢性疾病和残疾。只有一种药物可用于治疗血吸虫病，人们担心耐药性正在演变。