Deorphanization of Schistosome Cytochrome P450

 描述(由申请人提供)：这项R21探索性/发展研究提案的目标是确定曼氏血吸虫中唯一存在的细胞色素P450蛋白的功能，曼氏血吸虫是血吸虫病的病原体。我们推测，独特的血吸虫细胞色素P450对虫子的交流、生存、繁殖和发育是必不可少的，其功能可以通过将其与特定的代谢途径联系起来来确定。我们相信，了解该蛋白的功能将识别关键的信号通路，并将有助于发现治疗血吸虫病的新药。血吸虫病是一种重要的、被忽视的疾病，每年有超过2亿人感染，导致20万人死亡，以及数不清的慢性疾病和残疾。目前只有一种药物可用于治疗血吸虫病，人们担心抗药性正在演变。

 DESCRIPTION (provided by applicant): The goal of this R21 Exploratory/Developmental Research proposal is to identify the function of the only cytochrome P450 protein present in Schistosoma mansoni, a causative agent of schistosomiasis. We hypothesize that the unique schistosome cytochrome P450 is essential for worm communication, survival, reproduction, and development and that its function can be identified by linking it to specific metabolic pathways. We believe that understanding the function of this protein will identify critical signaling pathway and will be useful in the discovery of new drugs for schistosomiasis, an important, neglected disease with more than 200 million people infected resulting in 200,000 deaths annually and untold chronic illness and disability. Only one drug is available for schistosomiasis treatment and there are concerns that drug resistance is evolving.