Pathophysiology of focal human entrapment neuropathy

神经病变患者有刺痛、疼痛、麻木、自发肌肉收缩和痉挛等症状。这些症状反映了受累神经的异常激活。众所周知，外界的躁动会使症状恶化，比如腕管综合征（CTS）。本研究旨在探讨轴突膜离子通道功能的改变是否在症状中起作用。这将通过比较健康和CTS患者在外界刺激下的轴突膜离子通道功能来完成。

Neuropathy patients suffer from tingling, pain, numbness, spontaneous muscle contraction and cramp. The symptoms reflect abnormal activation of the nerve involved. It is known that an external agitation can worsen them, like in carpal tunnel syndrome (CTS). This study aims to investigate if changes in function of axonal membrane ion channel play any part in the symptoms. This will be done by comparing axonal membrane ion channel functions of healthy and CTS patients under external stimuli.