Pathophysiology of focal human entrapment neuropathy

局灶性人类卡压神经病的病理生理学

• 批准号: nhmrc : 510414
• 负责人: Seung Heon (Eric) Han
• 金额: $ 2.24万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathophysiology-focal-human-entrapment-neuropathy/115565
• 关键词: Pathophysiology; focal; human; entrapment; neuropathy

Neuropathy patients suffer from tingling, pain, numbness, spontaneous muscle contraction and cramp. The symptoms reflect abnormal activation of the nerve involved. It is known that an external agitation can worsen them, like in carpal tunnel syndrome (CTS). This study aims to investigate if changes in function of axonal membrane ion channel play any part in the symptoms. This will be done by comparing axonal membrane ion channel functions of healthy and CTS patients under external stimuli.

神经病患者会感到刺痛、疼痛、麻木、自发性肌肉收缩和痉挛。这些症状反映了相关神经的异常激活。众所周知，外部刺激会使症状恶化，例如腕管综合症（CTS）。本研究旨在调查轴突膜离子通道功能的变化是否与症状有关。这将通过比较健康人和 CTS 患者在外部刺激下的轴突膜离子通道功能来完成。