Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms

患有慢性疼痛的青少年的恐惧学习:神经和行为机制

基本信息

  • 批准号:
    9197686
  • 负责人:
  • 金额:
    $ 40.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-12-21 至 2020-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Chronic pain in childhood is a significant public health concern with median prevalence rates of 11 to 38%, with 3 to 5% of children suffering from significant pain-related disability (~3.5 million children in the US). Notwithstanding the physical and psychological consequences on overall health, chronic pain in childhood results in high levels of healthcare utilization and can predispose the development of chronic pain in adulthood. Fear is a particularly salient influence on pain outcomes and is the focus of the current research proposal. A significant proportion of youth with chronic pain endorse elevated pain-related fear. Pain-related fear is associated with high levels of disability, depressive symptoms, and school impairment. Beyond the individual, contextual influences substantially impact fear learning. Parents are profoundly affected when their child experiences pain and their (mal)adaptive response impacts outcomes. Thus, defining adolescent fear learning in chronic pain must incorporate parent distress and behavior. In the context of treatment, decreasing pain- related fear is associated with improved physical and psychological functioning, while high initial pain-related fear is a risk factor for less treatment responsiveness. Although it is recognized that high levels of pain-related fear can be detrimental, the neurobiological mechanisms for acquisition and extinction of fear have yet to be defined in pain patients. This is particularly germane during adolescence where neuronal properties are primed for modification by experience and the peak onset of chronic pain in childhood occurs. Moreover, extinction, the primary means of eradicating fear, is not consistently effective as fear may return when in a new context or under stress. Thus, more robust techniques are needed to diminish fear in a context-independent fashion. One method to prevent the return of fear is disruption of fear memory reconsolidation, where extinction occurs in a time window during which the fear memory is labile. This method, established in rodents and humans, has yet to be demonstrated in pediatric pain patients. This proposal investigates the mechanisms underlying fear learning, fear extinction, and disruption of fear reconsolidation in adolescents with chronic pain and healthy controls using behavioral and neuroimaging measures with the long-term goal of improving exposure-based treatments for adolescents with chronic pain. Aim 1 examines acquisition and extinction of fear learning behaviorally and neurobiologically in adolescents with chronic pain and low or high pain-related fear and healthy controls with consideration of the influence of parent fear and avoidance behavior. Aim 2 examines enhancement of fear extinction with disruption of fear memory reconsolidation. Currently, the treatment of chronic pain is suboptimal. Significant breakthroughs require a mechanistic understanding of key processes underlying pain-related dysfunction. Defining behavioral and neurobiological mechanisms of fear learning and extinction will lead to advancements in our understanding and treatment of persistent pain in adolescents.
项目摘要 儿童慢性疼痛是一个重要的公共卫生问题,中位患病率为11%至38%, 3 - 5%的儿童患有严重的疼痛相关残疾(美国约350万儿童)。 尽管对整体健康的生理和心理后果, 导致高水平的医疗保健利用,并可能使成年期慢性疼痛的发展成为可能。 恐惧是对疼痛结果的特别显著的影响,也是当前研究提案的重点。一 有相当一部分患有慢性疼痛青年赞同疼痛相关的恐惧加剧。疼痛相关的恐惧是 与高水平的残疾、抑郁症状和学校障碍有关。超越个人, 情境的影响实质上影响恐惧学习。当他们的孩子 经历疼痛和他们的(错误)适应性反应影响结果。因此,定义青少年恐惧学习 必须考虑到父母的痛苦和行为。在治疗方面,减轻疼痛- 相关的恐惧与改善的身体和心理功能有关,而高初始疼痛相关 恐惧是降低治疗反应的一个危险因素。尽管人们认识到高水平的疼痛相关的 恐惧可能是有害的,获得和消除恐惧的神经生物学机制还没有被发现。 疼痛患者的定义。这在青春期尤为重要,因为在青春期,神经元的特性是 通过经验准备进行修改,并且在儿童期出现慢性疼痛的高峰发作。此外,委员会认为, 灭绝是消除恐惧的主要手段,但并不总是有效的,因为恐惧可能会在新的环境中卷土重来。 背景或压力下。因此,需要更强大的技术来减少与上下文无关的恐惧。 时尚.防止恐惧回归的一种方法是破坏恐惧记忆的重新巩固, 消退发生在恐惧记忆不稳定的时间窗内。这种方法是在啮齿动物中建立的 和人类,尚未在儿科疼痛患者中得到证实。本提案探讨了 慢性疼痛青少年的潜在恐惧学习、恐惧消退和恐惧再巩固的破坏 使用行为和神经影像学方法,长期目标是改善 青少年慢性疼痛的治疗方法。目标1考察了 慢性疼痛和轻度或高度疼痛相关的青少年的行为学和神经生物学恐惧学习 恐惧和健康控制,考虑父母恐惧和回避行为的影响。目的2 研究了恐惧消退的增强与恐惧记忆重新巩固的破坏。目前 慢性疼痛的治疗是次优的。重大突破需要对关键技术的机械性理解, 疼痛相关功能障碍的潜在过程。定义恐惧的行为和神经生物学机制 学习和灭绝将导致我们对持续性疼痛的理解和治疗的进步, 青少年。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

LAURA E SIMONS其他文献

LAURA E SIMONS的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('LAURA E SIMONS', 18)}}的其他基金

Mentoring and Research in Biobehavioral Aspects of Pediatric Pain
小儿疼痛生物行为方面的指导和研究
  • 批准号:
    10370988
  • 财政年份:
    2022
  • 资助金额:
    $ 40.42万
  • 项目类别:
Mentoring and Research in Biobehavioral Aspects of Pediatric Pain
小儿疼痛生物行为方面的指导和研究
  • 批准号:
    10598517
  • 财政年份:
    2022
  • 资助金额:
    $ 40.42万
  • 项目类别:
Pain Rehabilitation Virtual Reality (PRVR): Innovations to enhance mobility in the presence of pain
疼痛康复虚拟现实 (PRVR):增强疼痛时活动能力的创新
  • 批准号:
    10397145
  • 财政年份:
    2021
  • 资助金额:
    $ 40.42万
  • 项目类别:
Pain Rehabilitation Virtual Reality (PRVR): Innovations to enhance mobility in the presence of pain
疼痛康复虚拟现实 (PRVR):增强疼痛时活动能力的创新
  • 批准号:
    10615631
  • 财政年份:
    2021
  • 资助金额:
    $ 40.42万
  • 项目类别:
Pain Rehabilitation Virtual Reality (PRVR): Innovations to enhance mobility in the presence of pain
疼痛康复虚拟现实 (PRVR):增强疼痛时活动能力的创新
  • 批准号:
    10209226
  • 财政年份:
    2021
  • 资助金额:
    $ 40.42万
  • 项目类别:
SPRINT: Signature for Pain Recovery IN Teens
SPRINT:青少年疼痛康复的标志
  • 批准号:
    10709409
  • 财政年份:
    2019
  • 资助金额:
    $ 40.42万
  • 项目类别:
Get moving, GET living: Graded exposure treatment for adolescents with chronic musculoskeletal pain.
行动起来,生活:针对患有慢性肌肉骨骼疼痛的青少年的分级暴露治疗。
  • 批准号:
    9980786
  • 财政年份:
    2018
  • 资助金额:
    $ 40.42万
  • 项目类别:
Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms
患有慢性疼痛的青少年的恐惧学习:神经和行为机制
  • 批准号:
    9349537
  • 财政年份:
    2015
  • 资助金额:
    $ 40.42万
  • 项目类别:
Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms
患有慢性疼痛的青少年的恐惧学习:神经和行为机制
  • 批准号:
    9551051
  • 财政年份:
    2015
  • 资助金额:
    $ 40.42万
  • 项目类别:
Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms
患有慢性疼痛的青少年的恐惧学习:神经和行为机制
  • 批准号:
    9757799
  • 财政年份:
    2015
  • 资助金额:
    $ 40.42万
  • 项目类别:

相似海外基金

Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa
COVID-19 大流行期间健康社会决定因素的变化对青少年和年轻人心理健康的影响:南非 Asenze 队列的纵向研究
  • 批准号:
    10755168
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
A Priority Setting Partnership to Establish a Patient, Caregiver, and Clinician-identified Research Agenda for Adolescent and Young Adult Cancer in Canada
建立优先合作伙伴关系,以建立患者、护理人员和临床医生确定的加拿大青少年和年轻人癌症研究议程
  • 批准号:
    480840
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
    Miscellaneous Programs
Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise
青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
  • 批准号:
    10678157
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
不同种族青少年和年轻成年癌症幸存者的生育经历:一项基于人群的研究
  • 批准号:
    10744412
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
Treatment development for refractory leukemia using childhood/adolescent, and young adult leukemia biobank
利用儿童/青少年和青年白血病生物库开发难治性白血病的治疗方法
  • 批准号:
    23K07305
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular design of Two-Way Player CAR-T cells to overcome disease/antigen heterogeneity of childhood, adolescent, and young adult cancers
双向 CAR-T 细胞的分子设计,以克服儿童、青少年和年轻成人癌症的疾病/抗原异质性
  • 批准号:
    23H02874
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Effects of adolescent social isolation on adult decision making and corticostriatal circuitry
青少年社会隔离对成人决策和皮质纹状体回路的影响
  • 批准号:
    10756652
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
Adolescent trauma produces enduring disruptions in sleep architecture that lead to increased risk for adult mental illness
青少年创伤会对睡眠结构产生持久的破坏,从而导致成人精神疾病的风险增加
  • 批准号:
    10730872
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
  • 批准号:
    10650648
  • 财政年份:
    2023
  • 资助金额:
    $ 40.42万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了