Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms
患有慢性疼痛的青少年的恐惧学习:神经和行为机制
基本信息
- 批准号:9197686
- 负责人:
- 金额:$ 40.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-12-21 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescenceAdolescentAdultAffectAftercareAmygdaloid structureAnteriorBehaviorBehavioralBehavioral MechanismsBrainChildChildhoodChronicCoupledCouplingDataDetectionDevelopmentDistressExtinction (Psychology)FrightFunctional Magnetic Resonance ImagingFunctional disorderGoalsHealthHourHumanImpairmentIndividualInsula of ReilLeadLearningMeasuresMethodsModificationNeurobiologyNeuronsOutcomePainPain managementParentsPatientsPatternPersistent painPredispositionPrefrontal CortexPrevalenceProcessPropertyProtocols documentationPsychological reinforcementPublic HealthResearchResearch ProposalsRiskRisk FactorsRodentSafetySchoolsStimulusStressSystemTechniquesTimeWorkYouthavoidance behaviorbasechronic paincognitive controlconditioningdepressive symptomsdisabilityexperiencefear memoryhealth care service utilizationimprovedlearning extinctionneural circuitneurobiological mechanismneuroimagingneuromechanismnovelparental influencepreventprotective behaviorpsychologicpublic health relevanceresilienceresponsetherapy resistant
项目摘要
PROJECT SUMMARY
Chronic pain in childhood is a significant public health concern with median prevalence rates of 11 to 38%, with
3 to 5% of children suffering from significant pain-related disability (~3.5 million children in the US).
Notwithstanding the physical and psychological consequences on overall health, chronic pain in childhood
results in high levels of healthcare utilization and can predispose the development of chronic pain in adulthood.
Fear is a particularly salient influence on pain outcomes and is the focus of the current research proposal. A
significant proportion of youth with chronic pain endorse elevated pain-related fear. Pain-related fear is
associated with high levels of disability, depressive symptoms, and school impairment. Beyond the individual,
contextual influences substantially impact fear learning. Parents are profoundly affected when their child
experiences pain and their (mal)adaptive response impacts outcomes. Thus, defining adolescent fear learning
in chronic pain must incorporate parent distress and behavior. In the context of treatment, decreasing pain-
related fear is associated with improved physical and psychological functioning, while high initial pain-related
fear is a risk factor for less treatment responsiveness. Although it is recognized that high levels of pain-related
fear can be detrimental, the neurobiological mechanisms for acquisition and extinction of fear have yet to be
defined in pain patients. This is particularly germane during adolescence where neuronal properties are
primed for modification by experience and the peak onset of chronic pain in childhood occurs. Moreover,
extinction, the primary means of eradicating fear, is not consistently effective as fear may return when in a new
context or under stress. Thus, more robust techniques are needed to diminish fear in a context-independent
fashion. One method to prevent the return of fear is disruption of fear memory reconsolidation, where
extinction occurs in a time window during which the fear memory is labile. This method, established in rodents
and humans, has yet to be demonstrated in pediatric pain patients. This proposal investigates the mechanisms
underlying fear learning, fear extinction, and disruption of fear reconsolidation in adolescents with chronic pain
and healthy controls using behavioral and neuroimaging measures with the long-term goal of improving
exposure-based treatments for adolescents with chronic pain. Aim 1 examines acquisition and extinction of
fear learning behaviorally and neurobiologically in adolescents with chronic pain and low or high pain-related
fear and healthy controls with consideration of the influence of parent fear and avoidance behavior. Aim 2
examines enhancement of fear extinction with disruption of fear memory reconsolidation. Currently, the
treatment of chronic pain is suboptimal. Significant breakthroughs require a mechanistic understanding of key
processes underlying pain-related dysfunction. Defining behavioral and neurobiological mechanisms of fear
learning and extinction will lead to advancements in our understanding and treatment of persistent pain in
adolescents.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LAURA E SIMONS其他文献
LAURA E SIMONS的其他文献
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{{ truncateString('LAURA E SIMONS', 18)}}的其他基金
Mentoring and Research in Biobehavioral Aspects of Pediatric Pain
小儿疼痛生物行为方面的指导和研究
- 批准号:
10370988 - 财政年份:2022
- 资助金额:
$ 40.42万 - 项目类别:
Mentoring and Research in Biobehavioral Aspects of Pediatric Pain
小儿疼痛生物行为方面的指导和研究
- 批准号:
10598517 - 财政年份:2022
- 资助金额:
$ 40.42万 - 项目类别:
Pain Rehabilitation Virtual Reality (PRVR): Innovations to enhance mobility in the presence of pain
疼痛康复虚拟现实 (PRVR):增强疼痛时活动能力的创新
- 批准号:
10397145 - 财政年份:2021
- 资助金额:
$ 40.42万 - 项目类别:
Pain Rehabilitation Virtual Reality (PRVR): Innovations to enhance mobility in the presence of pain
疼痛康复虚拟现实 (PRVR):增强疼痛时活动能力的创新
- 批准号:
10615631 - 财政年份:2021
- 资助金额:
$ 40.42万 - 项目类别:
Pain Rehabilitation Virtual Reality (PRVR): Innovations to enhance mobility in the presence of pain
疼痛康复虚拟现实 (PRVR):增强疼痛时活动能力的创新
- 批准号:
10209226 - 财政年份:2021
- 资助金额:
$ 40.42万 - 项目类别:
SPRINT: Signature for Pain Recovery IN Teens
SPRINT:青少年疼痛康复的标志
- 批准号:
10709409 - 财政年份:2019
- 资助金额:
$ 40.42万 - 项目类别:
Get moving, GET living: Graded exposure treatment for adolescents with chronic musculoskeletal pain.
行动起来,生活:针对患有慢性肌肉骨骼疼痛的青少年的分级暴露治疗。
- 批准号:
9980786 - 财政年份:2018
- 资助金额:
$ 40.42万 - 项目类别:
Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms
患有慢性疼痛的青少年的恐惧学习:神经和行为机制
- 批准号:
9349537 - 财政年份:2015
- 资助金额:
$ 40.42万 - 项目类别:
Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms
患有慢性疼痛的青少年的恐惧学习:神经和行为机制
- 批准号:
9551051 - 财政年份:2015
- 资助金额:
$ 40.42万 - 项目类别:
Fear learning in adolescents with chronic pain: Neural and behavioral mechanisms
患有慢性疼痛的青少年的恐惧学习:神经和行为机制
- 批准号:
9757799 - 财政年份:2015
- 资助金额:
$ 40.42万 - 项目类别:
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