Mentoring and Research in Biobehavioral Aspects of Pediatric Pain

项目摘要 这个K24应用程序的总体目标是扩展我当前的以患者为中心的研究(POR)和 指导将患者的参与从研究到护理的传播结合起来，以改善生物行为 护理患有慢性MSK疼痛的青少年。这一奖项将提供关键的保护时间来提高我的素质 以及对关注POR的初级调查人员的指导数量，包括目前的K奖获得者、未来的T-32 研究员和临床研究员(内科和心理学)。我目前支持的POR包括翻译 对机械信息治疗方法进行有针对性的生物心理社会评估，以实现最佳临床 护理，再加上疼痛神经科学心理学，利用实验和神经成像方法 获得对儿童认知和情感过程与功能相结合的机械理解 患有慢性疼痛和他们的父母。所有项目都利用无处不在的数字健康来加强患者的接触 然后伸手。我们的实验室在面向患者和患者的理论和机制研究方面拥有世界领先的专业知识 他们的家人。通过该奖项支持的研究的新方向侧重于获得新的专业知识。 以科学严谨的定性和协同设计方法与所有领域的患者及其家属合作 研究的各个阶段。这项申请提出了两项研究，在我的长期- 学期研究目的：改善慢性疼痛青年的健康和幸福感。研究1描述了 肌肉骨骼(MSK)疼痛青年的生活体验寻求、完成和反思疼痛护理。 研究2旨在共同设计我们的青少年循证分级暴露治疗的优化方案 患有慢性MSK疼痛的父母，继续生活。K24建立在我之前的研究基础上，利用现有的 队列和数据，添加新的培训，并巩固与患者参与性研究中的领导者的合作 和定性数据分析，为下一代POR儿科疼痛提供有效指导 科学家。在K24奖的支持下，我将提高我的指导能力，我将努力提高我的 职业发展，包括与我的辅导者、我的研究和我的专业发展相关的活动。 具体地说，我计划加深我对定性数据方法和分析以及患者参与性的理解 研究方法。此外，我还将投入时间，确保在法律和道德问题上继续接受培训。 参与人体研究和临床试验，并加强我的专业领导能力。 拟议的研究为通过实践培训增加指导机会提供了理想的背景 以患者为中心在儿科慢性疼痛生物行为学方面的科学发展 方法：研究方法。有了K24的奉献时间和培训，我将更有能力指导下一代 POR儿科疼痛科学家，并将以患者为中心的方法编织到所有研究中 行刑。

Project Summary The overall objective of this K24 application is to expand my current patient-oriented research (POR) and mentoring to integrate patient engagement from research to dissemination of care to improve the biobehavioral care of youth with chronic MSK pain. This award will provide the crucial protected time to enhance my quality and quantity of mentoring of junior investigators focused on POR including current K awardees, future T-32 fellows, and clinical fellows (physician and psychology). My currently supported POR encompasses translating targeted biopsychosocial assessments into mechanistically informed treatment approaches for optimal clinical care, coupled with pain neuroscience psychology that leverages experimental and neuroimaging methods to gain a mechanistic understanding of cognitive and affective processes that coalesce with function in children with chronic pain and their parents. All projects leverage the ubiquity of digital health to enhance patient access and reach. Our lab has world-leading expertise in theory- and mechanism-oriented research for patients and their families. The new direction of research to be supported through this award focuses on gaining new expertise in scientifically rigorous qualitative and codesign methods to partner with patients and their families across all stages of research. This application proposes two studies with significant mentoring opportunities within my long- term research objective to improve the health and well-being of youth with chronic pain. Study 1 characterizes the lived experience of youth with musculoskeletal (MSK) pain seeking, completing, and reflecting on pain care. Study 2 aims to codesign an optimization of our evidence-based graded exposure treatment for adolescents with chronic MSK pain and their parents, GET Living. The K24 builds on my previous research, leverages existing cohorts and data, adds new training, and solidifies collaborations with leaders in patient participatory research and qualitative data analysis to provide effective mentorship to the next generation of POR pediatric pain scientists. With support from the K24 award, I will enhance my mentoring capacity and I will work to enhance my career development with activities relevant to my mentees, my research, and my professional development. Specifically, I plan to deepen my understanding of qualitative data methods and analysis and patient participatory research methods. Moreover, I will dedicate time to ensure continued training in legal and ethical issues associated with research on human subjects and clinical trials and strengthen my professional leadership skills. The proposed studies provide the ideal context for enhancing mentorship opportunities via hands-on training and scientific development in the biobehavioral aspects of pediatric chronic pain applying patient-centered methods. With dedicated time and training from the K24, I will be better equipped to mentor the next generation of POR pediatric pain scientists and weave a patient-centered approach into all research from inception to execution.