The effect of EEG biomarkers of approach motivation and reward sensitivity on mood symptom stability

 描述（由申请人提供）：情绪障碍（MD）影响近15%的青年，并严重衰弱。情绪障碍通常通过适应性情绪调节的困难来表达，其在临床上表现为情绪的持续高反应性或低反应性（即，增加的焦虑、易怒或快感缺乏），以及过度接近或回避行为，导致严重的心理社会困难。与NIMH研究领域标准制定的策略一致，该项目旨在描述症状的特征。基于可观察行为和大脑功能的维度”，特别关注与正和负效价系统相关的生物标志物和行为，例如接近动机和对奖励/非奖励的反应。本研究旨在利用趋近动机、奖赏/非奖赏敏感性和行为反应（痛苦耐受）的神经生理学指标（脑电图（EEG）和事件相关电位（ERP））预测60例青年MD患者的情绪稳定性。识别症状维持的标志物将阐明干预目标并有助于治疗选择。该研究包括一个单一的实验室评估和两个症状随访评估，在3个月和6个月。该提案为申请人提供了最佳培训，以获得EEG方法和分析方面的专业知识，这些方法和分析需要对与接近动机和奖励敏感性相关的神经机制进行独立的，以患者为导向的神经发育研究。

 DESCRIPTION (provided by applicant): Mood disorders (MD) affect nearly 15% of youth and are severely debilitating. Mood impairments are often expressed through difficulties with adaptive emotion regulation that present clinically as persistent hyper- or hypo-reactivity of emotions (i.e., increased elation, irritability or anhedonia), and excessive approach or avoidance behaviors, resulting in significant psychosocial difficulties. Consistent with strategies set forthby the NIMH Research Domain Criteria, this project aims to characterize symptoms "...based on dimensions of observable behaviors and brain functions" with a particular focus on biomarkers and behaviors associated with the positive and negative valence systems, such as approach motivation and response to reward/non-reward. This proposal aims to use neurophysiological markers (electroencephalography [EEG] and event-related potentials [ERPs]) of approach motivation and reward/non-reward sensitivity, as well as behavioral response (distress tolerance), to predict mood stability in 60 youth with MD. Identifying markers of symptom maintenance will elucidate intervention targets and aid in treatment selection. The study involves a single laboratory assessment and two symptom follow-up assessments at 3- and 6-months. This proposal provides the optimal training for the applicant to gain expertise in EEG methods and analysis needed to conduct independent, patient-oriented, neurodevelopmental research on neural mechanisms associated with approach motivation and reward sensitivity.