Animal Facility

文摘：动物设施(AF) 希尔曼癌症中心动物设施(AF)是一个生物医学研究支持共享资源，包括 工作人员、服务和设施，致力于满足研究项目对动物的依赖需求 匹兹堡大学癌症研究所(UPCI)。AF的目标是提供专业知识、建议、设施、 当与癌症相关的调查需要使用动物模型时，人员、培训和协助。这个 AF的具体目标是：1)提供设计和实施方面的专业知识 使用动物模型的实验，2)维护设施、工作人员和提供专门用于满足 研究目标以及癌症研究人员的法规遵从性，3)提供兽医建议、培训、 动物使用方面的教育；以及咨询和技术支持，4)为生活提供支持和建议 根据需要进行动物成像项目，以及5)对组织进行详细的比较病理学检查 正如训练其他人进行这种分析一样。兽医技术支持、动物建模咨询、兽医 解释病理表型支持是房颤覆盖的主要服务。这个设施占据了 净面积13,085平方米英国《金融时报》在希尔曼癌症中心，研究展馆(HCC)，设计、管理和 致力于维持无特定病原体(SPF)的啮齿动物种群，使用屏障和微型隔离器笼子 系统和技术。自2010年以来，新的是翻新屏障后面的空间，以容纳小动物 静脉内瘘的MRI和小动物PET/CT表现。此共享资源是 由机构动物保护和使用委员会(IACUC)监督的大学动物项目。这个 匹兹堡大学动物保护和利用项目(000496单元)获得完全认证(最近一次更新于3月， 2014)，由国际实验动物护理评估和认可协会， 通过AAALAC的网站http://www.aaalac.org/accreditedorgs/index.cfm.确认此外，该大学还拥有 在NIH OLAW(#A3187-01)备案的保证书，上次续签是在2012年6月，并且是有效的 到2016年5月，并在美国农业部注册为研究机构 (23-R-0024)。在本项目期间，UPCI研究项目的所有10个项目的调查人员使用 自动对焦。

Abstract: Animal Facility (AF) The Hillman Cancer Center Animal Facility (AF) is a biomedical research support shared resource consisting of staff, services, and facilities dedicated to meeting the animal-dependent needs of the research programs of the University of Pittsburgh Cancer Institute (UPCI). The goal of the AF is to provide expertise, advice, facilities, personnel, training, and assistance when cancer-related investigations require the use of animal models. The specific aims of the AF are to 1) Provide professional expertise in the design and implementation of experiments that use animal models, 2) Maintain facilities, staff, and supply resources dedicated to meet research goals as well as regulatory compliance for cancer investigators, 3) Provide veterinary advice, training, education in animal use; and consultation as well as technical support, 4) Provide support and advice for live animal imaging projects as needed, and 5) Perform detailed comparative pathology review of tissues, as well as train others in this analysis. Veterinary technical support, animal modeling consultation, and veterinary interpretive pathologic phenotypic support are the main services covered by the AF. The facility occupies 13,085 net sq. ft. in the Hillman Cancer Center, Research Pavilion (HCC) and is designed, managed, and dedicated to maintain specific pathogen free (SPF) rodent populations, using barrier and micro-isolator caging systems and techniques. New since 2010 is renovation of space behind the barrier to house the small animal MRI and small animal PET/CT modalities of the IVIF. This shared resource is an integral component of the University’s animal program overseen by the Institutional Animal Care and Use Committee (IACUC). The University of Pittsburgh Animal Care and Use Program (Unit #000496) is fully accredited (last updated March, 2014) by the Association for the Assessment and Accreditation of Laboratory Animal Care International, affirmed via AAALAC’s website http://www.aaalac.org/accreditedorgs/index.cfm. In addition, the University has a letter of assurance on file with OLAW, NIH (#A3187-01) that was last renewed in June 2012 and is valid through May 2016, and is registered as a research institution with the United States Department of Agriculture (23-R-0024). During the current project period investigators in all 10 of the UPCI Research Programs used the AF.