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A critical test of Neural Models of Risk Among Adolescent Assault Victims

青少年袭击受害者风险神经模型的关键测试

基本信息

批准号：
9389072
负责人：
Joshua M Cisler
金额：
$ 7.1万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-15 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9389072
关键词：
critical test Neural Models Risk

项目摘要

DESCRIPTION (provided by applicant): This proposal for a NIMH Exploratory/Developmental Grant Award (R21) seeks to critically evaluate and expand upon leading neurocircuitry models of trauma and PTSD among assaulted adolescent girls. Existing neurocircuitry models of trauma and PTSD focus almost exclusively on identifying the neural mechanisms that explain observed hypervigilance for threat and deficits in fear extinction learning. While these models have ample empirical support, they do not explain known deficits in risk perceptions of social situations and increased rates of revictimization among assault-exposed and PTSD populations. By contrast, our pilot study demonstrated that assaulted adolescent girls display both worse behavioral performance and decreased activation of anterior cingulate cortex and bilateral anterior insular cortex during a social learning task, which suggests a novel mechanism to explain known social functioning deficits in these populations. Based on these pilot data, we hypothesize that expanding existing neurorcircuitry models to include weakened brain and behavioral correlates of social prediction error encoding increases explanatory power for PTSD symptoms and functional deficits among assaulted adolescent girls. We propose to recruit control, assaulted without PTSD, and assaulted with PTSD adolescent girls and administer both a threat processing task and our previously used social learning task during fMRI. Participants would also complete a standardized risk perception task, in which they are presented with written vignettes depicting increasingly dangerous social situations. Aim 1 seeks to demonstrate that weakened encoding of social prediction errors among assaulted adolescent girls mediates decreased risk perceptions to the standardized risk social situation vignettes when controlling for variance explained by neural mechanisms on the threat processing task. Aim 2 seeks to demonstrate that weakened encoding of social prediction errors among assaulted adolescent girls predicts 3-month trajectories of PTSD symptoms when controlling for variance explained by neural mechanisms on the threat detection task. The overarching purpose of the proposed project is to demonstrate increased explanatory power of a neurocircuitry model that includes social processing deficits. Successful completion of the proposed project would stimulate new conceptualizations of the toxic effects of early life trauma and PTSD, and hopefully lead to improved prevention and treatment programs.