Enhancing independence in elders with serious illness

描述（由申请人提供）：西奈山OAIC的创新使命是刺激，发展和资助研究，以提高生活质量和严重疾病的老年人及其照顾者的独立性。在我们的第一个四年进行的活动， OAIC建立在西奈山老龄化和姑息治疗开创性研究的基础上，使西奈山OAIC成为改善我国最严重病人护理运动的关键贡献者。自2009年成立以来，我们已经：1）定义了老年姑息治疗的新领域; 2）招募和培训了新一代的老年姑息治疗研究人员（逆着全国的趋势）谁正在解决我们最脆弱的病人的问题; 3）通过创新研究加强了改善重病老年人及其照顾者生活质量和独立性的证据基础;和4）与西奈山国家姑息治疗研究中心（NCPRC）合作创建了一个全国老年姑息治疗研究人员网络，NCPRC是一个慈善支持的中心，致力于在全国范围内促进和资助姑息治疗研究。由OAIC和NPCRC支持的早期调查人员已经收到了超过2600万美元的后续校外联邦资金。 第一次更新的目的是：1）扩大我们的综合性，跨学科的研究计划，重点是提高生活质量和独立性，并开发和测试改善老年人严重疾病护理的模型; 2）识别，招募和培训老龄化和姑息治疗研究的领导者; 3）扩大研究基础设施，以支持新的和正在进行的护理重病老年人的研究;和4）的方法建立一个研究中心，将老年医学和姑息治疗的跨学科专业联系起来，作为这两个领域都没有得到很好解决的研究的典范特产我们通过考虑全方位的转化研究，通过一个全面的框架，连接和协调的活动，开始与创建一个管道的学员，支持他们的研究开发，提供基础设施和资源的研究，培育和促进合作研究，最后，有针对性地努力宣传改善老年人及其家庭生活的工作。我们汇集了西奈山的研究资源，与该地区的其他专家合作，并通过NPCRC利用全国专家和学员网络。为了扩大OAIC的影响力，我们还提出了新的创新举措，包括成立一个新的Pepper Center兴趣小组和一个新的核心，重点关注转化研究的最后一步，即将研究成果付诸实践。通过战略性地利用地方和国家资源，并在其他成功项目的基础上，OAIC建议通过创建一个范围全面、在地方影响力方面具有重大意义、在全国范围内具有影响力的中心来最大限度地发挥其影响力。

DESCRIPTION (provided by applicant): The Mount Sinai OAIC's innovative mission is to stimulate, develop, and fund research to improve quality of life and independence of older adults with serious illness and their caregivers. The activities conducted during the first 4 years of our OAIC, building upon a foundation of pioneering research in aging and palliative care at Mount Sinai, have resulted in the Mount Sinai OAIC emerging as a key contributor in the movement to improve care for our nation's sickest patients. Since inception in 2009, we have: 1) defined a new field of geriatric palliative care; 2) recruited and trained a new generation of geriatric palliative care researchers (bucking a national trend) who are addressing the problems of our most vulnerable patients; 3) enhanced the evidence base for improving quality of life and independence in seriously ill older adults and their caregivers through innovative research; and 4) created a national network of geriatric palliative care researchers in collaboration with Mount Sinai's National Palliative Care Research Center (NCPRC) - a philanthropically supported center focused on promoting and funding palliative care research nationwide. Early stage investigators supported by the OAIC and NPCRC have received over $26 million in subsequent extramural federal funding. The objective of this first renewal is to 1) expand our comprehensive, transdisciplinary research program focused on improving quality of life and independence and developing and testing models of improving care for older adults living with serious illness; 2) identify, recruit and train leaders in aging and palliative care research; 3) expand a research infrastructure that will support new and ongoing research in the care of seriously ill older adults; and 4) develop a research center that bridges the transdisciplinary specialties of geriatrics and palliative care an that will serve as a model for research that has not been well addressed by either of these two specialties. We approach the work of advancing research in geriatric palliative care and its translation by considering the full range of translational research through a comprehensive framework of connected and coordinated activities that starts with creating a pipeline of trainees, supporting their research development, providing infrastructure and resources for research, nurturing and facilitating collaborative research, and ends with targeted efforts to disseminate the work to improve the life of older persons and their families. We bring together research resources at Mount Sinai, engage other experts in the region, and leverage a national network of experts and trainees through the NPCRC. To amplify the OAIC's impact, we also propose new innovative initiatives, including the formation of a new Pepper Center interest group and a new core focused on the often-neglected and final step of translational research-the implementation of research findings into practice. By strategically leveraging local and national resources and building on other successful programs, the OAIC proposes to maximize its impact by creating a Center that is comprehensive in scope, significant in its local impact, and national in its reach.