Comprehensive Translational Science Analytics Tools for the Global Health Agenda

描述（由申请人提供）：美国国立卫生研究院已宣布其意图利用科学的力量，通过评估其在现实世界环境中的相对有效性和成本效益，确定产生最大效益的卫生干预措施。因此，循证方法将指导基础生物医学研究转化为常规临床实践和公共卫生政策。美国国立卫生研究院的承诺与全球2000多名公共卫生专业人员签署的《悉尼宣言》一致。《宣言》建议，将专门用于艾滋病毒规划的所有资源的10%用于研究，以优化所采用的干预措施和实现健康成果，并断言，如果不进行这种持续努力，就不可能结束艾滋病毒/艾滋病流行。尽管呼吁加大投资，但实施科学方法论的实质性创新尚未实现。开发相关和可获取的方法和软件，使健全的循证实践能够为实现千年发展目标作出重要贡献；具体来说，就是消灭艾滋病毒/艾滋病，普及艾滋病治疗，降低孕产妇和5岁以下儿童死亡率。美国作为世界上艾滋病毒/艾滋病救济和其他全球卫生倡议的主要资助者，在以证据为基础的情况下，将这一大规模投资用于改善世界各地的健康和减轻人类痛苦，对美国至关重要。本提案的目的是通过开发一个全面的转化科学分析工具包来推进实施科学的新兴领域——这是研究者、从业者和政策制定者非常需要的资源，他们试图通过将研究成果和证据整合到医疗保健政策和实践中来推动当今全球和国内卫生议程。首席研究员将在她的职业轨迹上进行根本性的转变，以开发新的方法并适应现有的方法

DESCRIPTION (provided by applicant): The NIH has declared its intention to leverage the power of science to identify health interventions that yield the greatest benefits by assessing their relative effectiveness and cost-effectiveness in real- world settings. Thus, evidence-based approaches will guide the translation of basic biomedical research into routine clinical practice and public health policy. The NIH's commitment aligns with the Sydney Declaration, signed by more than 2,000 public health professionals worldwide. This Declaration recommends that 10% of all resources dedicated to HIV programming be used for research towards optimizing interventions utilized and health outcomes achieved, and asserts that without such a sustained effort, ending the HIV/AIDS epidemic will not be possible. Despite calls for greater investment, substantive innovation in implementation science methodology has not yet materialized. Development of relevant and accessible methodology and software to enable sound evidence-based practice stands to contribute importantly to meeting the Millennium Development Goals; specifically, ending the HIV/AIDS epidemic, providing universal access to AIDS treatment, and reducing maternal and under-5 child mortality. The United States, as the world's leading funder of HIV/AIDS relief and other global health initiatives, has a vital stake in an evidence-based deployment of this massive investment in improving health and alleviating human suffering worldwide. The purpose of this proposal is to advance the emerging field of implementation science by developing a comprehensive translational science analytics toolkit-a much needed resource for investigators, practitioners, and policymakers who seek to drive today's global and domestic health agenda through the integration of research findings and evidence into healthcare policy and practice. The principal investigator will undertake a fundamental shift in her career trajectory, to develop new methods and adapt existin