Comprehensive Translational Science Analytics Tools for the Global Health Agenda

描述(由申请人提供)：美国国立卫生研究院已经宣布，它打算利用科学的力量，通过评估它们在现实世界中的相对有效性和成本效益来确定产生最大好处的卫生干预措施。因此，循证方法将指导将基础生物医学研究转化为常规临床实践和公共卫生政策。美国国立卫生研究院的承诺与悉尼宣言一致，该宣言由全球2000多名公共卫生专业人员签署。该宣言建议将用于艾滋病毒方案规划的所有资源的10%用于研究，以优化利用的干预措施和取得的健康成果，并断言，如果没有这种持续的努力，就不可能结束艾滋病毒/艾滋病的流行。尽管呼吁加大投资，但执行科学方法方面的实质性创新尚未实现。开发相关的、可获得的方法和软件，以实现可靠的循证做法，将对实现千年发展目标作出重要贡献；具体地说，就是结束艾滋病毒/艾滋病流行病，普及艾滋病治疗，降低产妇和五岁以下儿童死亡率。美国作为世界上艾滋病毒/艾滋病救济和其他全球卫生倡议的主要资助者，在以证据为基础部署这项大规模投资以改善世界各地的健康和减轻人类痛苦方面具有至关重要的利害关系。这项建议的目的是通过开发全面的翻译科学分析工具包来推进新兴的实施科学领域-这是研究人员、从业者和政策制定者迫切需要的资源，他们寻求通过将研究结果和证据整合到医疗保健政策和实践中来推动当今的全球和国内卫生议程。首席调查员将对她的职业轨迹进行根本性转变，以开发新方法并适应现有

DESCRIPTION (provided by applicant): The NIH has declared its intention to leverage the power of science to identify health interventions that yield the greatest benefits by assessing their relative effectiveness and cost-effectiveness in real- world settings. Thus, evidence-based approaches will guide the translation of basic biomedical research into routine clinical practice and public health policy. The NIH's commitment aligns with the Sydney Declaration, signed by more than 2,000 public health professionals worldwide. This Declaration recommends that 10% of all resources dedicated to HIV programming be used for research towards optimizing interventions utilized and health outcomes achieved, and asserts that without such a sustained effort, ending the HIV/AIDS epidemic will not be possible. Despite calls for greater investment, substantive innovation in implementation science methodology has not yet materialized. Development of relevant and accessible methodology and software to enable sound evidence-based practice stands to contribute importantly to meeting the Millennium Development Goals; specifically, ending the HIV/AIDS epidemic, providing universal access to AIDS treatment, and reducing maternal and under-5 child mortality. The United States, as the world's leading funder of HIV/AIDS relief and other global health initiatives, has a vital stake in an evidence-based deployment of this massive investment in improving health and alleviating human suffering worldwide. The purpose of this proposal is to advance the emerging field of implementation science by developing a comprehensive translational science analytics toolkit-a much needed resource for investigators, practitioners, and policymakers who seek to drive today's global and domestic health agenda through the integration of research findings and evidence into healthcare policy and practice. The principal investigator will undertake a fundamental shift in her career trajectory, to develop new methods and adapt existin