Comprehensive Translational Science Analytics Tools for the Global Health Agenda

全球健康议程的综合转化科学分析工具

• 批准号: 8928183
• 负责人: DONNA L SPIEGELMAN
• 金额: $ 80.75万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-16 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8928183
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adoption; Biomedical Research; Books; Child Mortality; Computer software; Decision Making; Development; Educational Curriculum; Educational process of instructing; Effectiveness; Epidemic; Evaluation; Evidence based practice; Federal Government; Goals; HIV; Health; Health Policy; Health Professional; Hospitals; Human; Intention; Intervention; Investments; Local Government; Medicare; Methodology; Methods; Monograph; Outcome; Peer Review; Principal Investigator; Public Health; Publications; Relative (related person); Research; Research Personnel; Resources; Science; State Government; Translational Research; Translations; United States; United States National Institutes of Health; career; clinical practice; cost effectiveness; evidence base; global health; implementation science; improved; innovation; intervention program; meetings; novel; programs; sound; tool

DESCRIPTION (provided by applicant): The NIH has declared its intention to leverage the power of science to identify health interventions that yield the greatest benefits by assessing their relative effectiveness and cost-effectiveness in real- world settings. Thus, evidence-based approaches will guide the translation of basic biomedical research into routine clinical practice and public health policy. The NIH's commitment aligns with the Sydney Declaration, signed by more than 2,000 public health professionals worldwide. This Declaration recommends that 10% of all resources dedicated to HIV programming be used for research towards optimizing interventions utilized and health outcomes achieved, and asserts that without such a sustained effort, ending the HIV/AIDS epidemic will not be possible. Despite calls for greater investment, substantive innovation in implementation science methodology has not yet materialized. Development of relevant and accessible methodology and software to enable sound evidence-based practice stands to contribute importantly to meeting the Millennium Development Goals; specifically, ending the HIV/AIDS epidemic, providing universal access to AIDS treatment, and reducing maternal and under-5 child mortality. The United States, as the world's leading funder of HIV/AIDS relief and other global health initiatives, has a vital stake in an evidence-based deployment of this massive investment in improving health and alleviating human suffering worldwide. The purpose of this proposal is to advance the emerging field of implementation science by developing a comprehensive translational science analytics toolkit-a much needed resource for investigators, practitioners, and policymakers who seek to drive today's global and domestic health agenda through the integration of research findings and evidence into healthcare policy and practice. The principal investigator will undertake a fundamental shift in her career trajectory, to develop new methods and adapt existin

描述（由申请人提供）：美国国立卫生研究院已宣布其打算利用科学的力量，通过评估现实世界环境中的相对有效性和成本效益来确定能够产生最大效益的健康干预措施。因此，循证方法将指导基础生物医学研究转化为常规临床实践和公共卫生政策。 NIH 的承诺与由全球 2,000 多名公共卫生专业人员签署的《悉尼宣言》一致。该宣言建议将专门用于艾滋病毒规划的所有资源的 10% 用于研究，以优化干预措施的使用和实现的健康成果，并断言，如果没有这种持续的努力，就不可能结束艾滋病毒/艾滋病的流行。尽管呼吁加大投资，但实施科学方法的实质性创新尚未实现。开发相关且易于使用的方法和软件，以实现健全的循证实践，将为实现千年发展目标做出重要贡献；具体而言，结束艾滋病毒/艾滋病流行、普及艾滋病治疗以及降低孕产妇和 5 岁以下儿童死亡率。美国作为艾滋病毒/艾滋病救济和其他全球卫生倡议的世界主要资助者，在以证据为基础部署这一用于改善健康和减轻全世界人类痛苦的大规模投资方面有着至关重要的利益。 该提案的目的是通过开发一个全面的转化科学分析工具包来推动新兴的实施科学领域的发展，这是研究人员、从业者和政策制定者急需的资源，他们寻求通过将研究结果和证据整合到医疗保健政策和实践中来推动当今的全球和国内健康议程。首席研究员将对她的职业轨迹进行根本性转变，开发新方法并适应现有方法