GUIDE: Genomic Uses in Infectious Diseases and Epidemics

指南:基因组在传染病和流行病中的应用

基本信息

  • 批准号:
    8869019
  • 负责人:
  • 金额:
    $ 26.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-06-16 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Genomic information offers the opportunity for "personalized prevention" in both clinical practice and public health settings. To date, such efforts have focused primarily on chronic diseases and their behavioral risk factors. We propose an exploratory CEER to study the ethical, legal, social and policy (ELSP) issues arising in the novel and timely context of infectious disease. The proposed P20, "GUIDE: Genomic Uses in Infectious Disease & Epidemics, would be the first to map this terrain, and prepare for a Center to analyze relevant ELSP issues and make policy recommendations for addressing them. During the planning phase we will gather multidisciplinary content experts at Johns Hopkins to achieve four specific aims: (SA1): Create an organizational infrastructure, consisting of a Working Group and various intra-institutional, governmental and community stakeholders who will engage in a multidisciplinary dialogical approach that is standard in bioethics, to identify ad address emerging issues in the application of genomics to infectious diseases. (SA2): Illuminate the ELSP implications of advances in genomics for two paradigmatic viral diseases: (a) pandemic flu as an acute infection, and (b) Hepatitis C as a chronic infection. Through key informant interviews, focus groups, and white papers on the legal and policy issues, we will highlight the utility and ELSP implications of genomics for prevention (vaccine development, safety and efficacy, distribution and allocation) and treatment (severity of infection, efficacy/response of potential therapies, side effects, allocation). (SA3): Document information dissemination and communication about genomics and infectious diseases in the scientific, public health and social media domains. (SA4): Develop a vision and plan for a Center of Excellence (P50) on the ELSP implications of advances in genomics for infectious diseases. In developing the comprehensive research and training programs for the P50, we will apply what we learn from our "case studies" to other infectious diseases that are transmitted from human-to-human (e.g., HIV, HPV, tuberculosis), and broaden our reach to include additional categories of infectious disease such as insect-borne (e.g., malaria, Dengue fever, Chagas disease) and, perhaps, food-borne infections.
描述(由申请人提供):基因组信息为临床实践和公共卫生环境中的“个性化预防”提供了机会。迄今为止,此类努力主要集中在慢性病及其行为风险因素上。我们提出了一个探索性的CEER来研究在新的和及时的传染病背景下出现的伦理、法律、社会和政策(ELSP)问题。拟议的P20“指南:基因组学在传染病和流行病中的应用”将首次绘制这一领域的地图,并为一个中心分析相关的ELSP问题并为解决这些问题提出政策建议做准备。在规划阶段,我们将在约翰霍普金斯大学召集多学科内容专家,以实现四个具体目标:(SA1):创建一个组织基础设施,由一个工作组和各种机构内、政府和社区利益攸关方组成,这些利益攸关方将参与生物伦理学标准的多学科对话方法,以确定和解决基因组学应用于传染病方面出现的新问题。(SA2):阐明基因组学进展对两种典型病毒性疾病的ELSP影响:(a)作为急性感染的大流行性流感,(b)作为慢性感染的丙型肝炎。通过重要的信息提供者访谈、焦点小组和关于法律和政策问题的白皮书,我们将强调基因组学在预防(疫苗开发、安全性和有效性、分配和分配)和治疗(感染的严重程度、潜在疗法的有效性/反应、副作用、分配)方面的效用和ELSP影响。(SA3):在科学、公共卫生和社会媒体领域记录基因组学和传染病的信息传播和交流。(SA4):为一个卓越中心(P50)制定愿景和计划,研究基因组学进展对传染病的ELSP影响。在为P50制定全面的研究和培训计划时,我们将把我们从“案例研究”中学到的知识应用于其他人与人之间传播的传染病(如艾滋病毒、人乳头瘤病毒、结核病),并扩大我们的研究范围,包括其他传染病类别,如虫媒传染病(如疟疾、登革热、恰加斯病),也许还有食源性感染。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Genomics and infectious disease: a call to identify the ethical, legal and social implications for public health and clinical practice.
  • DOI:
    10.1186/s13073-014-0106-2
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    12.3
  • 作者:
    Geller G;Dvoskin R;Thio CL;Duggal P;Lewis MH;Bailey TC;Sutherland A;Salmon DA;Kahn JP
  • 通讯作者:
    Kahn JP
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GAIL GELLER其他文献

GAIL GELLER的其他文献

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{{ truncateString('GAIL GELLER', 18)}}的其他基金

Ethical, Legal and Social Issues for Precision Medicine and Infectious Disease
精准医学和传染病的伦理、法律和社会问题
  • 批准号:
    9274346
  • 财政年份:
    2016
  • 资助金额:
    $ 26.88万
  • 项目类别:
Ethical, Legal and Social Issues for Precision Medicine and Infectious Disease
精准医学和传染病的伦理、法律和社会问题
  • 批准号:
    9111423
  • 财政年份:
    2016
  • 资助金额:
    $ 26.88万
  • 项目类别:
GUIDE: Genomic Uses in Infectious Diseases and Epidemics
指南:基因组在传染病和流行病中的应用
  • 批准号:
    8514766
  • 财政年份:
    2013
  • 资助金额:
    $ 26.88万
  • 项目类别:
GUIDE: Genomic Uses in Infectious Diseases and Epidemics
指南:基因组在传染病和流行病中的应用
  • 批准号:
    8682894
  • 财政年份:
    2013
  • 资助金额:
    $ 26.88万
  • 项目类别:
A Vision of Hope: Integration of Palliative Care in Chronic Pediatric Diseases
希望的愿景:姑息治疗在慢性儿科疾病中的整合
  • 批准号:
    7936869
  • 财政年份:
    2009
  • 资助金额:
    $ 26.88万
  • 项目类别:
A Vision of Hope: Integration of Palliative Care in Chronic Pediatric Diseases
希望的愿景:姑息治疗在慢性儿科疾病中的整合
  • 批准号:
    7821519
  • 财政年份:
    2009
  • 资助金额:
    $ 26.88万
  • 项目类别:
Moral Distress and Suffering of Genetics Professionals
遗传学专业人士的道德困境和痛苦
  • 批准号:
    7279976
  • 财政年份:
    2005
  • 资助金额:
    $ 26.88万
  • 项目类别:
Moral Distress and Suffering of Genetics Professionals
遗传学专业人士的道德困境和痛苦
  • 批准号:
    6965793
  • 财政年份:
    2005
  • 资助金额:
    $ 26.88万
  • 项目类别:
Moral Distress and Suffering of Genetics Professionals
遗传学专业人士的道德困境和痛苦
  • 批准号:
    7123956
  • 财政年份:
    2005
  • 资助金额:
    $ 26.88万
  • 项目类别:
PUBLICIZING GENETIC DISCOVERIES--THE IMPACT OF THE MEDIA
宣传基因发现——媒体的影响
  • 批准号:
    6181654
  • 财政年份:
    1998
  • 资助金额:
    $ 26.88万
  • 项目类别:

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