IP Landscape Search for Applications of Fluorescent Nanodiamonds

摘要 本CRP提案的总体目标是进行知识产权前景研究 用于生物医学和制药市场的荧光钻石。NV中心 纳米金刚石表现出明亮、高度稳定的荧光，其延伸到近红外 光谱区它们具有生物相容性，永不褪色，光漂白或闪烁，并显示荧光 比常用的有机染料更亮。这些特征使得荧光 纳米金刚石非常适合于药物递送和生物医学成像应用，例如细胞 用于超分辨率显微镜的标记、细胞跟踪和基准标记。荧光 金刚石和纳米金刚石在其它领域具有额外的和基本上未开发的应用， 市场，如场传感器，自旋电子学，以及在药品，医疗防伪 仪器、植入物和诊断套件。虽然荧光纳米金刚石 看起来有利可图，没有荧光纳米金刚石的商业来源，直到 哥伦布纳米工厂获得了第一阶段SBIR合同，生产荧光纳米金刚石 在商业规模上。我们目前在我们的第二阶段SBIR合同的第6个月继续 这项工作以及开发额外的钻石色心。一个主要领域，现在需要 我们的注意力是了解荧光钻石的知识产权前景。我们要求 从商业化准备计划中拨款， 物业搜索和景观分析，侧重于成分，生产方法和 用于荧光金刚石和纳米金刚石的应用。如荧光钻石， 纳米金刚石是新的，我们相信围绕它们的知识产权将是相当有限的， IP景观搜索将加强我们在这个市场的地位。这项研究将使我们能够 促进和保护我们的产品，最大限度地发挥我们的商业竞争潜力。更深 了解荧光纳米金刚石领域的知识产权将使我们能够 调动我们的发展努力以获得最大利益，发展富有成效的伙伴关系， 吸引投资者，并开发技术解决方案和商业战略，以避免自由， 实践/侵权风险。

ABSTRACT The broad objective of this CRP proposal is to conduct an intellectual property landscape study for the use of fluorescent diamonds in biomedical and pharmaceutical markets. NV-center nanodiamonds exhibit bright, highly stable fluorescence which extends into the near infrared spectral region. They are biocompatible, never fade, photobleach or blink and show fluorescence that is much brighter than commonly used organic dyes. These features make fluorescent nanodiamonds ideally suited for drug delivery and biomedical imaging applications, such as cell labeling, cell tracking, and fiducial marking for super resolution microscopy. Fluorescent diamonds and nanodiamonds have additional and essentially untapped applications in other markets such as field sensors, spintronics, and in anti-counterfeiting of pharmaceuticals, medical instruments, implants and diagnostic kits. While the opportunity for fluorescent nanodiamonds appears lucrative, there were no commercial sources of fluorescent nanodiamonds until Columbus NanoWorks received a Phase I SBIR contract to produce fluorescent nanodiamonds on a commercial scale. We are currently in month 6 of our Phase II SBIR contract to continue this work as well as develop additional diamond color centers. A major area that now requires our attention is understanding the IP landscape for fluorescent diamonds. We are requesting funding from the Commercialization Readiness Program to carefully conduct an intellectual property search and landscape analysis focused on compositions, production methods and applications of use for fluorescent diamonds and nanodiamonds. As fluorescent diamonds and nanodiamonds are new, we believe that the IP surrounding them will be fairly limited and that an IP landscape search will strengthen our position in this market. This study will enable us to advance and protect our products and maximize our commercial competitive potential. A deeper understanding of the intellectual property in the fluorescent nanodiamond space will allow us to maneuver our development efforts for the greatest benefit, develop productive partnerships and attract investors, and develop technical solutions and business strategies to avoid freedom to practice/infringement risks.