Core A - Animal core
Core A - Animal core
批准号:
9151386
负责人:
Mark S Anderson
金额:
$25.24万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-06-08 至 2021-05-31
关键词:
Animal HusbandryAnimalsAutoimmune ProcessAutoimmunityBackcrossingsBiological ProcessBreedingComplexDiabetes MellitusEnsureEnvironmentGenerationsGeneticImmune ToleranceInbred NOD MiceIncidenceInsulin-Dependent Diabetes MellitusKnock-outMaintenanceMouse StrainsMusResearch PersonnelT-LymphocyteTransgenic Organismsabstractinganimal facilitygenetic makeupimprovedmemberpathogenprogramstool
中文摘要
项目摘要/摘要
转基因小鼠的使用彻底改变了对许多复杂生物过程的研究。
包括免疫耐受和自身免疫。这一点清楚地反映在这个PPG的所有项目中,这些项目
严重依赖转基因、基因敲除和有自身免疫倾向的小鼠品系的使用。鼠标核心是
预计这将有助于简化和提高效率,从而生成和维护
在健康、无病原体的环境中培育基因复杂的品系。
这一核心的具体目标是:
1.培育独特的和非常规的小鼠品系,并对其进行基因鉴定,以供所有计划使用
项目成员。
2.协助计划项目成员将新获得或派生的菌株常规回交到
为计划的研究提供适当的遗传背景
3.确保提供给计划项目成员的动物健康并保持在无病原体的环境中
建议进行研究的环境。
核心的可用性确保PPG调查人员将能够获得健康和无病原体的
用于拟议研究的复杂遗传构成的动物。
英文摘要
Project Summary/Abstract
The use of genetically altered mice has revolutionized the study of many complex biological processes
including immune tolerance and autoimmunity. This is clearly reflected in all the projects in this PPG, which
rely heavily on the use of transgenic, knockout, and autoimmune-prone mouse strains. A mouse Core is
envisioned that will help streamline and improve efficiencies with the generation and maintenance of
genetically complex lines in a healthy, pathogen-free environment.
The specific aims of this Core are:
1. To breed and genetically characterize unique and non-routine mouse strains for use by all of the program
project members.
2. To assist program project members with routine backcrossing of newly obtained or derived strains to the
appropriate genetic backgrounds for planned studies
3. To ensure animals provided to program project members are healthy and maintained in a pathogen-free
environment for the proposed studies.
The availability of the Core ensures that the PPG investigators will be able to obtain healthy and pathogen-free
animals of complex genetic make-up for use in the proposed studies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Administrative Core
-
批准号:10328098
-
项目类别:
-
资助金额:$8.08万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Project 2: STAT3 as a trigger for T1D
-
批准号:10576386
-
项目类别:
-
资助金额:$17.54万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
STAT3 variants as a rheostat of immune tolerance
-
批准号:10328097
-
项目类别:
-
资助金额:$176.58万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Tuning peptide specifities for T cell tolerance in Type 1 diabetes
-
批准号:10630946
-
项目类别:
-
资助金额:$46.85万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Alterations of leukocyte integrin signaling leading to diabetes and autoimmunity
-
批准号:10502136
-
项目类别:
-
资助金额:$64.67万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Project 2: STAT3 as a trigger for T1D
-
批准号:10328102
-
项目类别:
-
资助金额:$40.38万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Core A: Mouse Core
-
批准号:10328099
-
项目类别:
-
资助金额:$24.11万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Tuning peptide specifities for T cell tolerance in Type 1 diabetes
-
批准号:10503923
-
项目类别:
-
资助金额:$44.95万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Alterations of leukocyte integrin signaling leading to diabetes and autoimmunity
-
批准号:10683384
-
项目类别:
-
资助金额:$66.63万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Core A: Mouse Core
-
批准号:10576378
-
项目类别:
-
资助金额:$24.11万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
STAT3 variants as a rheostat of immune tolerance
-
批准号:10576375
-
项目类别:
-
资助金额:$176.56万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Administrative Core
-
批准号:10576377
-
项目类别:
-
资助金额:$8.08万
-
财政年份:2022
-
负责人:Mark S Anderson
-
依托单位:
Immune Tolerance Network
-
批准号:10625931
-
项目类别:
-
资助金额:$684.91万
-
财政年份:2021
-
负责人:Mark S Anderson
-
依托单位:
Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems
-
批准号:10179371
-
项目类别:
-
资助金额:$95.17万
-
财政年份:2019
-
负责人:Mark S Anderson
-
依托单位:
Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems
-
批准号:10413178
-
项目类别:
-
资助金额:$95.17万
-
财政年份:2019
-
负责人:Mark S Anderson
-
依托单位:
Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems
-
批准号:10020398
-
项目类别:
-
资助金额:$95.13万
-
财政年份:2019
-
负责人:Mark S Anderson
-
依托单位:
Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems
-
批准号:10762177
-
项目类别:
-
资助金额:$42.5万
-
财政年份:2019
-
负责人:Mark S Anderson
-
依托单位:
Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
-
批准号:9106605
-
项目类别:
-
资助金额:$57.84万
-
财政年份:2016
-
负责人:Mark S Anderson
-
依托单位:
Project 1 - Central thymic tolerance as a major checkpoint in T1D
-
批准号:9151388
-
项目类别:
-
资助金额:$39.63万
-
财政年份:2016
-
负责人:Mark S Anderson
-
依托单位:
Disruption of T cell tolerance in type 1 diabetes
-
批准号:9291418
-
项目类别:
-
资助金额:$162.91万
-
财政年份:2016
-
负责人:Mark S Anderson
-
依托单位:
海外基金