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Development of a low-cost hardware accelerator for 3D image registration

开发用于 3D 图像配准的低成本硬件加速器

基本信息

批准号：
8820128
负责人：
Raj Shekhar
金额：
$ 29.5万
依托单位：
IGI TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-07 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8820128
关键词：
3-Dimensional Acceleration Address Agreement Algorithms Anatomy Atlases Capital Cardiology Clinical Communication Complex Computer software Custom Data Development Diagnosis Discipline Disease Disease Progression Disease regression Economics Goals Head and Neck Neoplasms Hospital Planning Hospitals Hour Hybrids Image Legal patent Licensing Magnetic Resonance Imaging Malignant Neoplasms Maryland Medical Imaging Memory Methods Modality Modeling Modern Medicine Monitor Neurology Organ Patients Performance Phase Physiological Positioning Attribute Procedures Publications Radiation therapy Radiology Specialty Research Sampling Secure Small Business Technology Transfer Research Solutions Speed System Systems Integration Technology Testing Time Universities University Hospitals Woman Work X-Ray Computed Tomography base clinical efficacy commercialization cost design follow-up image guided intervention image registration imaging informatics improved meetings minimally invasive multimodality novel oncology population based prevent programs prototype radiologist research clinical testing response software development tool trend tumor ablation user-friendly

项目摘要

DESCRIPTION (provided by applicant): Our overall goal is to develop a novel computing solution for automatic and accurate registration (spatial alignment) of 3-dimensional (3D) medical images of any modality and any anatomy (rigid or deformable) in 1 minute or less. Such capability currently does not exist. Existing image registration solutions have limited accuracy and/or limited applicability, preventing wide and routine clinical use. Building on significant prior academic research, we demonstrated the feasibility of creating the proposed technology in Phase I of this project. We now propose to create a fully functional turnkey prototype-a compact, relatively low-cost (manufacturing cost: ~$20,000) PC board-of hardware- accelerated image registration, with commercialization as the ultimate goal. Image registration is a fundamental need in modern medicine-a need that remains unmet. It is the necessary first step before images with complementary information can be fused or images taken at different times can be subtracted to quantify anatomic/physiologic changes. It is also essential when creating a population- based atlas from images of many subjects. Image registration has numerous other applications, including the registration of pre- and intra-operative images in a host of emerging minimally invasive image-guided interventions, especially those to treat cancer. Our 4 specific aims for Phase II are to: (1) create a fully integrated prototype of 1-min image registration; (2) develop software for convenient third-party integration and technology demonstration; (3) perform PACS (picture archival and communication system) integration and analyze enterprise-wide utilization; and (4) develop high- impact model applications. These aims will continue the progress made in Phase I and help create a clinically tested and viable multipurpose image registration computing technology. The proposed Phase II work will also put us in a strong position to secure private capital and licensing agreements and pursue commercialization. Our proposed low-cost, ultrafast, easy-to-use, and accurate computing solution promises to unlock the full potential of medical image registration in virtually all clinical disciplines, including radiology, oncology, neurology, and cardiology.

描述（由申请人提供）：我们的总体目标是开发一种新的计算解决方案，用于在1分钟或更短时间内对任何模态和任何解剖结构（刚性或可变形）的三维（3D）医学图像进行自动和准确的配准（空间对齐）。目前尚不存在这种能力。现有的图像配准解决方案具有有限的准确性和/或有限的适用性，阻止了广泛和常规的临床使用。基于先前的重要学术研究，我们证明了在该项目的第一阶段创建拟议技术的可行性。我们现在建议创建一个功能齐全的交钥匙原型-一个紧凑的，相对低成本（制造成本：20,000美元）的PC板硬件加速图像配准，与商业化的最终目标。图像配准是现代医学的一个基本需求，但这一需求仍未得到满足。这是必要的第一步，然后才能融合具有互补信息的图像，或者可以减去在不同时间拍摄的图像，以量化解剖/生理变化。当从许多主题的图像创建基于人口的地图集时，它也是必不可少的。图像配准具有许多其他应用，包括在许多新兴的微创图像引导干预中的术前和术中图像的配准，特别是用于治疗癌症的那些。第二阶段的4个具体目标是：（1）创建一个完全集成的1分钟图像配准原型;（2）开发方便第三方集成和技术演示的软件;（3）执行PACS（图片存档和通信系统）集成并分析企业范围内的利用率;（4）开发高影响力模型应用程序。这些目标将继续在第一阶段取得的进展，并帮助创建一个临床测试和可行的多用途图像配准计算技术。拟议的第二阶段工作也将使我们处于有利地位，以确保私人资本和许可协议，并追求商业化。我们提出的低成本、超快、易于使用和准确的计算解决方案有望在几乎所有临床学科（包括放射学、肿瘤学、神经学和心脏病学）中释放医学图像配准的全部潜力。