Development of a low-cost hardware accelerator for 3D image registration

开发用于 3D 图像配准的低成本硬件加速器

• 批准号: 8652719
• 负责人: Raj Shekhar
• 金额: $ 18.83万
• 依托单位: IGI TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8652719
• 关键词: 3-Dimensional; Ablation; Acceleration; Address; Agreement; Algorithms; Anatomy; Atlases; Capital; Cardiology; Clinical; Communication; Complex; Computer software; Custom; Data; Development; Diagnosis; Discipline; Disease; Disease Progression; Disease regression; Economics; Goals; Head and Neck Neoplasms; Hospital Planning; Hospitals; Hour; Hybrids; Image; Legal patent; Licensing; Magnetic Resonance Imaging; Malignant Neoplasms; Maryland; Medical Imaging; Memory; Methods; Modality; Modeling; Modern Medicine; Monitor; Neurology; Organ; Patients; Performance; Phase; Physiological; Positioning Attribute; Procedures; Publications; Radiation therapy; Radiology Specialty; Research; Sampling; Secure; Simulate; Small Business Technology Transfer Research; Solutions; Speed; System; Systems Integration; Technology; Testing; Time; Universities; University Hospitals; Woman; Work; X-Ray Computed Tomography; base; clinical efficacy; commercialization; cost; design; follow-up; image guided intervention; image registration; imaging informatics; improved; meetings; minimally invasive; multimodality; novel; oncology; population based; prevent; programs; prototype; radiologist; research clinical testing; response; software development; tool; trend; tumor; user-friendly

Our overall goal is to develop a novel computing solution for automatic and accurate registration (spatial alignment) of 3-dimensional (3D) medical images of any modality and any anatomy (rigid or deformable) in 1 minute or less. Such capability currently does not exist. Existing image registration solutions have limited accuracy and/or limited applicability, preventing wide and routine clinical use. Building on significant prior academic research, we demonstrated the feasibility of creating the proposed technology in Phase I of this project. We now propose to create a fully functional turnkey prototype-a compact, relatively low-cost (manufacturing cost: ~$20,000) PC board-of hardware- accelerated image registration, with commercialization as the ultimate goal. Image registration is a fundamental need in modern medicine-a need that remains unmet. It is the necessary first step before images with complementary information can be fused or images taken at different times can be subtracted to quantify anatomic/physiologic changes. It is also essential when creating a population- based atlas from images of many subjects. Image registration has numerous other applications, including the registration of pre- and intra-operative images in a host of emerging minimally invasive image-guided interventions, especially those to treat cancer. Our 4 specific aims for Phase II are to: (1) create a fully integrated prototype of 1-min image registration; (2) develop software for convenient third-party integration and technology demonstration; (3) perform PACS (picture archival and communication system) integration and analyze enterprise-wide utilization; and (4) develop high- impact model applications. These aims will continue the progress made in Phase I and help create a clinically tested and viable multipurpose image registration computing technology. The proposed Phase II work will also put us in a strong position to secure private capital and licensing agreements and pursue commercialization. Our proposed low-cost, ultrafast, easy-to-use, and accurate computing solution promises to unlock the full potential of medical image registration in virtually all clinical disciplines, including radiology, oncology, neurology, and cardiology.

我们的总体目标是开发一种新型的计算解决方案，以通过1分钟或更短的任何方式（刚性或可变形）的3维（3D）医学图像进行自动和准确的注册（空间比对）。当前不存在此类功能。现有的图像注册解决方案的准确性和/或适用性有限，可防止广泛而常规的临床用途。在重要的先前学术研究的基础上，我们证明了在该项目的第一阶段创建拟议技术的可行性。现在，我们建议创建一个功能齐全的交钥匙原型-A紧凑，相对较低的成本（制造成本：〜20,000美元）PC硬件加速图像注册，并以商业化为最终目标。图像注册是现代医学的基本需求 - 尚未满足的需求。在可以融合具有互补信息的图像或在不同时间拍摄的图像以量化解剖/生理变化之前，这是必要的第一步。从许多受试者的图像中创建基于人群的地图集时，这也是必不可少的。图像注册还有许多其他应用，包括在许多新兴的微创图像引导的干预措施中，尤其是治疗癌症的术中和术中图像的注册。我们对II期的4个具体目标是：（1）创建1分钟图像注册的完全集成的原型； （2）开发用于方便的第三方集成和技术演示的软件； （3）执行PACS（图片档案和通信系统）集成并分析企业范围的利用； （4）开发高影响模型应用。这些目标将继续在第一阶段取得的进展，并帮助创建经过临床测试且可行的多功能图像注册计算技术。拟议的第二阶段工作还将使我们处于确保私人资本和许可协议并进行商业化的强大立场。我们提出的低成本，超快，易于使用和准确的计算解决方案有望在几乎所有临床学科中释放医学图像注册的全部潜力，包括放射学，肿瘤学，神经病学和心脏病学。