Pathways for Skeletal Muscle Hypertrophy

骨骼肌肥大的途径

• 批准号: nhmrc : 109000
• 负责人: Prof Bob Graham
• 金额: $ 22.2万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathways-skeletal-muscle-hypertrophy/77678
• 关键词: Pathways; Skeletal; Muscle; Hypertrophy

Maintenance of skeletal muscle integrity is critical for normal locomotor function. During adulthood skeletal muscle mass and strength is progressively lost which leads to locomotor impairment common in the elderly. Loss of skeletal muscle may also contribute to functional impairment in patients with inherited disorders of the scaffolding connective tissue that hold muscle fibres together, such as Duchenne's dystrophy. Understanding the biology of muscle cell growth and responses to environmental stresses such as exercise and ageing is, therefore, critical to healthy daily functioning. In preliminary studies we have defined a novel biochemical pathway which we believe underlies the ability of muscle to grow larger and stronger. In this application, we propose to rigorously evaluate the role of this pathway in muscle growth by experiments performed both with cell culture models and in animals. The findings of this study would have direct therapeutic benefit for a large number of major clinical conditions, such as heart failure, age-related muscular weakness and muscle diseases.

维持骨骼肌的完整性对于正常的运动功能是至关重要的。在成年期，骨骼肌质量和强度逐渐丧失，导致老年人常见的运动障碍。骨骼肌的丧失也可能导致患有将肌纤维保持在一起的支架结缔组织遗传性疾病的患者的功能障碍，例如杜氏营养不良症。因此，了解肌肉细胞生长的生物学和对环境压力（如运动和衰老）的反应对健康的日常功能至关重要。在初步研究中，我们已经确定了一种新的生化途径，我们认为这是肌肉变得更大更强的能力的基础。在本申请中，我们建议通过细胞培养模型和动物实验来严格评估该途径在肌肉生长中的作用。这项研究的结果将对许多主要的临床疾病有直接的治疗益处，如心力衰竭、与年龄相关的肌无力和肌肉疾病。