Molecular mechanisms of cardiac function and disease

心脏功能和疾病的分子机制

• 批准号: nhmrc : 354400
• 负责人: Prof Bob Graham
• 金额: $ 547.69万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-cardiac-function-disease/97293
• 关键词: Molecular; mechanisms; cardiac; function; disease

Heart disease remains the leading cause of death in our society. Almost two million Australians suffer from the debilitating effects of heart disease and it is the leading cause of premature permanent disability in our workers. Heart defects are also the most common type of birth defect and the leading cause of deaths in infants dying from birth defects. Many of these problems can be attributed directly to defects in the development, repair and-or function of heart muscle and, at the cellular level, of heart muscle cells or cardiomyocytes. Understanding the cardiomyocyte as well as integrated heart development, biology, physiology and function, therefore, holds great promise for major advances in the prevention and treatment of contemporary heart diseases. This Program Grant brings together a unique team of interactive researchers with expertise in cardiovascular physiology, as well as developmental, cellular and molecular biology. The outcomes anticipated from new insights into heart biology that will result from the proposed studies, are the development of novel therapeutic approaches for the prevention and treatment of heart attacks and heart failure.

心脏病仍然是我们社会的主要死亡原因。近200万澳大利亚人患有心脏病，这是导致我们的工人过早永久残疾的主要原因。心脏缺陷也是最常见的出生缺陷类型，也是婴儿死于出生缺陷的主要原因。许多这些问题可以直接归因于心脏肌肉的发育，修复和或功能缺陷，在细胞水平上，心脏肌肉细胞或心肌细胞。因此，了解心肌细胞以及综合心脏发育、生物学、生理学和功能，对当代心脏病的预防和治疗取得重大进展具有很大的希望。该项目资助汇集了一支独特的互动研究团队，他们在心血管生理学，以及发育，细胞和分子生物学方面具有专业知识。从心脏生物学的新见解中预期的结果将从拟议的研究中得到，是预防和治疗心脏病发作和心力衰竭的新治疗方法的发展。