Molecular mechanisms of cardiac function and disease

心脏病仍然是我们社会的主要死亡原因。近200万澳大利亚人遭受心脏病的衰弱影响，这是我们工人过早永久残疾的主要原因。心脏缺陷也是最常见的出生缺陷类型，也是死于出生缺陷的婴儿的主要死亡原因。这些问题中的许多可以直接归因于心肌发育、修复和/或功能的缺陷，在细胞水平上，心肌细胞或心肌细胞。因此，了解心肌细胞以及心脏发育、生物学、生理学和功能的综合，对当代心脏病的预防和治疗具有重大进展的希望。该项目汇集了一支独特的互动研究团队，他们在心血管生理学以及发育、细胞和分子生物学方面具有专业知识。拟议的研究将产生对心脏生物学的新见解，预期的结果是开发新的治疗方法来预防和治疗心脏病发作和心力衰竭。

Heart disease remains the leading cause of death in our society. Almost two million Australians suffer from the debilitating effects of heart disease and it is the leading cause of premature permanent disability in our workers. Heart defects are also the most common type of birth defect and the leading cause of deaths in infants dying from birth defects. Many of these problems can be attributed directly to defects in the development, repair and-or function of heart muscle and, at the cellular level, of heart muscle cells or cardiomyocytes. Understanding the cardiomyocyte as well as integrated heart development, biology, physiology and function, therefore, holds great promise for major advances in the prevention and treatment of contemporary heart diseases. This Program Grant brings together a unique team of interactive researchers with expertise in cardiovascular physiology, as well as developmental, cellular and molecular biology. The outcomes anticipated from new insights into heart biology that will result from the proposed studies, are the development of novel therapeutic approaches for the prevention and treatment of heart attacks and heart failure.