Molecular mechanisms of cardiac function and disease

心脏功能和疾病的分子机制

• 批准号: nhmrc : 573732
• 负责人: Prof Bob Graham
• 金额: $ 670.34万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-cardiac-function-disease/99104
• 关键词: Molecular; mechanisms; cardiac; function; disease

Adult-onset heart disease remains the leading cause of death and disability in our society, with almost 2 million Australians affected. Furthermore, structural heart malformations are the most common type of abnormality at birth and the leading cause of deaths in infants dying from non-infectious causes. Many of these problems are due to defects in the development, repair and-or function of heart muscle cells or cardiomyocytes. Thus, we propose to understand, in fine detail, cardiomyocyte as well as integrated heart development, biology, physiology and function as a prerequisite for the development of major advances in the prevention and treatment of these disorders.

成人心脏病仍然是造成我们社会死亡和残疾的主要原因，有近200万澳大利亚人受到影响。此外，结构性心脏畸形是出生时最常见的畸形类型，也是婴儿死于非感染性原因的主要原因。许多这些问题是由于心脏肌肉细胞或心肌细胞的发育、修复或功能缺陷造成的。因此，我们建议详细了解心肌细胞以及综合心脏发育、生物学、生理学和功能，作为在预防和治疗这些疾病方面取得重大进展的先决条件。