Pathways to treatment in blinding genetic retinal eye diseases

致盲遗传性视网膜眼病的治疗途径

• 批准号: nhmrc : 1099165
• 负责人: A/Pr John Grigg
• 金额: $ 38.15万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathways-treatment-blinding-eye-diseases/662429
• 关键词: Pathways; treatment; blinding; genetic; retinal

Blinding eye diseases with genetic contributing factors affecting the retina or light-sensing part of the eye, damage the vision of millions of people worldwide. The vision impairment is irreversible, untreatable, and worsens with age. In this project, we will use technological breakthroughs in genome correction and sequencing, in combination with stem cell and mouse model applications, to develop pathways to treatment of these currently incurable diseases.

致盲性眼病的遗传因素影响视网膜或眼睛的感光部分，损害了全世界数百万人的视力。视力损害是不可逆转的，无法治疗的，并随着年龄的增长而增加。在这个项目中，我们将利用基因组校正和测序方面的技术突破，结合干细胞和小鼠模型应用，开发治疗这些目前无法治愈的疾病的途径。