Peptide toxins from animal venoms specifically targeting voltage-gated sodium channels as novel analgesics and pesticides

来自动物毒液的肽毒素专门针对电压门控钠通道作为新型镇痛剂和杀虫剂

• 批准号: nhmrc : 1070030
• 负责人: Dr Rong Chen
• 金额: $ 21.1万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/peptide-toxins-animal-analgesics-pesticides/455421
• 关键词: Peptide; toxins; animal; venoms; specifically

This project aims to understand how certain animal toxins that cause analgesic and pesticidal effects in model animals interact with biological ion channels in atomistic detail using computational techniques. By understanding the detailed molecular interactions involved in the binding of the toxins to channels, toxin variants with improved potency and specificity may be designed as promising templates for novel analgesics and pesticides.

该项目旨在了解某些在模型动物中产生止痛和杀虫作用的动物毒素如何使用计算技术与生物离子通道进行原子细节的相互作用。通过了解毒素与通道结合所涉及的详细分子相互作用，具有更高效力和特异性的毒素变体可能被设计为新型止痛药和杀虫剂的有希望的模板。