Animal toxins as novel analgesics and pesticides

作为新型镇痛剂和杀虫剂的动物毒素

• 批准号: nhmrc : GNT1070030
• 负责人: Dr Rong Chen
• 金额: $ 20.31万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/animal-toxins-novel-analgesics-pesticides/1344980
• 关键词: Animal; toxins; novel; analgesics; pesticides

This project aims to understand how certain animal toxins that cause analgesic and pesticidal effects in model animals interact with biological ion channels in atomistic detail using computational techniques. By understanding the detailed molecular interactions involved in the binding of the toxins to channels, toxin variants with improved potency and specificity may be designed as promising templates for novel analgesics and pesticides.

该项目旨在了解某些动物毒素如何在模型动物中引起镇痛和杀虫作用，并使用计算技术以原子细节与生物离子通道相互作用。通过了解毒素与通道结合所涉及的详细分子相互作用，可以将具有改进的效力和特异性的毒素变体设计为用于新型镇痛剂和杀虫剂的有希望的模板。