Performance and safety testing of the BioQ cardiac assist system in a chronic ovine heart failure animal model

BioQ 心脏辅助系统在慢性羊心力衰竭动物模型中的性能和安全性测试

• 批准号: nhmrc : 571931
• 负责人: A/Pr Craig Mclachlan
• 金额: $ 9.52万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/performance-safety-testing-animal-model/76644
• 关键词: Performance; safety; testing; BioQ; cardiac

This proposal will test a novel cardiac assist system in safety and performance studies using a chronic sheep heart failure model. This device has been tested in cardiovascular simulators and in an acute animal model showing attractive proof-of-concept data. Specifically, the device increased left coronary artery blood flow and reduced aortic pulse and mean pressures using our novel self-powered fully implantable stand alone device, a potential therapy treatment for heart failure.

该提案将使用慢性绵羊心力衰竭模型在安全性和性能研究中测试新型心脏辅助系统。该设备已在心血管模拟器和急性动物模型中进行了测试，显示出有吸引力的概念验证数据。具体而言，该设备增加了左冠状动脉血流量，并减少了主动脉脉搏和平均压力，使用我们的新型自供电完全植入式独立设备，一种潜在的治疗心力衰竭的治疗方法。