Reversing oxidative inhibition of the Na-K pump by beta3 adrenergic agonists: implications for heart failure therapy

β3 肾上腺素能激动剂逆转 Na-K 泵的氧化抑制：对心力衰竭治疗的影响

• 批准号: nhmrc : 633252
• 负责人: A/Pr Craig Mclachlan
• 金额: $ 35.58万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reversing-oxidative-inhibition-failure-therapy/96019
• 关键词: Reversing; oxidative; inhibition; Na; pump

Heart failure is a debilitating condition characterised by a decreased heart pump function. Raised Na+ levels and increased oxidative stress in cardiac cells are important in its causation. While traditional antioxidants are not useful in treatment, we have found that a group of drugs designed to induce weight loss can reverse oxidative inhibition of the mechanism that pumps Na+ out of heart cells. The effect of these drugs on the Na+ pumping mechanism and heart failure will be examined.

心力衰竭是一种以心脏泵功能下降为特征的衰弱性疾病。心肌细胞中Na+水平升高和氧化应激增加是其重要原因。虽然传统的抗氧化剂在治疗中没有用，但我们发现一组旨在诱导减肥的药物可以逆转将Na+泵出心脏细胞的机制的氧化抑制。将检查这些药物对Na+泵送机制和心力衰竭的影响。