Periconceptual foundations for a healthy start to life.

先入为主和早孕是妇女健康和未来孩子健康的关键时期。一项新的研究表明，女性的基因潜力、生活方式、所处的物质和社会经济环境，以及她与男性伴侣的生物学和社会关系，都会对宝宝的长期健康产生影响。怀孕期间和怀孕早期的异常事件可能使新生儿在成年后容易发生心脏病、糖尿病、肥胖和中风等疾病。这些不良事件起源于卵子和精子的发育，子宫为植入做好准备，早期胚胎附着在子宫内层，以及随后胎盘的生长。这一计划将研究早期生活事件，这些事件促进或限制了婴儿成功和健康生活的真正潜力的发展。更好地了解生活方式和环境如何与基因和生物学相互作用，以促进胎儿的最佳生长，将为不孕不育、流产和其他生殖疾病的新的预防措施和治疗方法奠定基础。所获得的知识将为卫生政策和临床实践提供依据，以改善所有澳大利亚妇女的生殖健康，促进所有澳大利亚儿童的健康发展。研究团队是一个世界级的临床医生、科学家和流行病学家组成的团队，他们为我们对这一领域的理解做出了重大贡献。该小组将与怀孕前和怀孕期间与妇女接触的诊所和医院进行接触，同时具有改变临床和卫生做法以及公共卫生政策的影响力。该团队将利用最新、最先进的实验室方法和临床技能，包括基因图谱、早期怀孕成像、随机临床试验以及获得最佳流行病学和统计评估。

Preconception and early pregnancy is a critical time for a women's health and that of her future child. New research suggests that a woman's genetic potential, her lifestyle and the physical and socioeconomic environment in which she lives, and her biological and social relationship with her male partner, all impact on the long term health of her baby. Abnormal events around the time of conception and in early pregnancy can predispose a newborn to later occurrence, in adult life, of conditions including heart disease, diabetes, obesity and stroke. These adverse events originate in the way that eggs and sperm develop, the uterus is prepared for implantation, the attachment of the early embryo to the lining of the uterus and subsequent growth of the placenta. This Program will study the early life events that promote or limit development of a baby's true potential for successful and healthy life. A better understanding of how lifestyle and environment interact with genes and biology to facilitate optimal growth of the fetus will underpin new preventative measures and therapeutic treatments for infertility, miscarriage and other reproductive disorders. The knowledge gained will inform health policy and clinical practise to improve reproductive health in all Australian women and promote healthy development in all Australian children. The team of researchers is a world-class group of clinicians, scientists and epidemiologists who have made major contributions to our understanding of this area. This team will interface with clinics and hospitals that engage with women prior to and during pregnancy, while having the influence to alter clinical and health practices as well as public health policies. The team will utilize the latest, most technologically advanced laboratory methods and clinical skills, including gene profiling, imaging of early pregnancy, randomised clinical trials and access to the best epidemiological and statistical assessments.