Periconceptual foundations for a healthy start to life.

孕前和早孕是妇女及其未来孩子健康的关键时期。新的研究表明，女性的遗传潜力、生活方式、生理和社会经济环境，以及与男性伴侣的生理和社会关系，都会影响婴儿的长期健康。怀孕前后和妊娠早期的异常事件可使新生儿在成年后易患心脏病、糖尿病、肥胖症和中风等疾病。这些不良事件源于卵子和精子发育的方式，子宫为着床做准备，早期胚胎附着在子宫内膜上以及随后胎盘的生长。该项目将研究促进或限制婴儿成功和健康生活的真正潜力发展的早期生活事件。更好地了解生活方式和环境如何与基因和生物学相互作用，以促进胎儿的最佳生长，将为不孕症、流产和其他生殖障碍提供新的预防措施和治疗方法。所获得的知识将为卫生政策和临床实践提供信息，以改善所有澳大利亚妇女的生殖健康，促进所有澳大利亚儿童的健康发展。该研究团队由世界级的临床医生、科学家和流行病学家组成，他们为我们对这一领域的理解做出了重大贡献。该小组将与与怀孕前和怀孕期间妇女接触的诊所和医院联系，同时对改变临床和卫生做法以及公共卫生政策产生影响。该团队将利用最新、技术最先进的实验室方法和临床技能，包括基因分析、早期妊娠成像、随机临床试验以及获得最佳流行病学和统计评估。

Preconception and early pregnancy is a critical time for a women's health and that of her future child. New research suggests that a woman's genetic potential, her lifestyle and the physical and socioeconomic environment in which she lives, and her biological and social relationship with her male partner, all impact on the long term health of her baby. Abnormal events around the time of conception and in early pregnancy can predispose a newborn to later occurrence, in adult life, of conditions including heart disease, diabetes, obesity and stroke. These adverse events originate in the way that eggs and sperm develop, the uterus is prepared for implantation, the attachment of the early embryo to the lining of the uterus and subsequent growth of the placenta. This Program will study the early life events that promote or limit development of a baby's true potential for successful and healthy life. A better understanding of how lifestyle and environment interact with genes and biology to facilitate optimal growth of the fetus will underpin new preventative measures and therapeutic treatments for infertility, miscarriage and other reproductive disorders. The knowledge gained will inform health policy and clinical practise to improve reproductive health in all Australian women and promote healthy development in all Australian children. The team of researchers is a world-class group of clinicians, scientists and epidemiologists who have made major contributions to our understanding of this area. This team will interface with clinics and hospitals that engage with women prior to and during pregnancy, while having the influence to alter clinical and health practices as well as public health policies. The team will utilize the latest, most technologically advanced laboratory methods and clinical skills, including gene profiling, imaging of early pregnancy, randomised clinical trials and access to the best epidemiological and statistical assessments.