The obesity prone oocyte- causes, consequences, treatments

容易肥胖的卵母细胞 - 原因、后果、治疗

• 批准号: nhmrc : 1061819
• 负责人: A/Pr Jeremy Thompson
• 金额: $ 34.42万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/obesity-prone-oocyte-consequences-treatments/454936
• 关键词: obesity; prone; oocyte; causes; consequences

Obesity is perpetuated from mothers to offspring, in part due to changes in the oocyte (egg) that affect embryo growth. We have discovered that obesity causes changes in the mitochondria (the energy producers) of the egg. We hypothesise this causes long-lasting changes to embryo metabolism and will test, in mice, novel treatments to reverse the detrimental effects. The project will show how obesity affects embryo metabolism and growth, and determine whether defects can be prevented by drugs or lifestyle changes.

肥胖是从母亲传给后代的，部分原因是卵母细胞(卵子)的变化影响了胚胎的生长。我们已经发现，肥胖会导致鸡蛋线粒体(能量产生者)的变化。我们假设这会导致胚胎新陈代谢的长期变化，并将在小鼠身上测试逆转有害影响的新疗法。该项目将展示肥胖如何影响胚胎新陈代谢和生长，并确定缺陷是否可以通过药物或生活方式的改变来预防。