The obesity prone oocyte- causes, consequences, treatments
The obesity prone oocyte- causes, consequences, treatments
批准号:
nhmrc : 1061819
负责人:
A/Pr Jeremy Thompson
金额:
$34.42万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
肥胖是从母亲传给后代的,部分原因是卵母细胞(卵子)的变化影响了胚胎的生长。我们已经发现,肥胖会导致鸡蛋线粒体(能量产生者)的变化。我们假设这会导致胚胎新陈代谢的长期变化,并将在小鼠身上测试逆转有害影响的新疗法。该项目将展示肥胖如何影响胚胎新陈代谢和生长,并确定缺陷是否可以通过药物或生活方式的改变来预防。
英文摘要
Obesity is perpetuated from mothers to offspring, in part due to changes in the oocyte (egg) that affect embryo growth. We have discovered that obesity causes changes in the mitochondria (the energy producers) of the egg. We hypothesise this causes long-lasting changes to embryo metabolism and will test, in mice, novel treatments to reverse the detrimental effects. The project will show how obesity affects embryo metabolism and growth, and determine whether defects can be prevented by drugs or lifestyle changes.
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会议论文
New insights into oocyte and embryo health
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批准号:nhmrc : 1077694
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项目类别:Research Fellowships
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资助金额:$52.04万
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财政年份:2015
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负责人:A/Pr Jeremy Thompson
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依托单位:
Inflammatory cytokines as causal agents in peri-conception programming of offspring health
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批准号:nhmrc : 1079150
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项目类别:Project Grants
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资助金额:$40.28万
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财政年份:2015
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负责人:A/Pr Jeremy Thompson
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依托单位:
EGF peptide signalling improves oocyte maturation and quality
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批准号:nhmrc : 1062762
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项目类别:Project Grants
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资助金额:$39.13万
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财政年份:2014
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负责人:A/Pr Jeremy Thompson
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依托单位:
Technology for hormone-free infertility treatment
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批准号:nhmrc : 1076004
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项目类别:Development Grants
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资助金额:$38.1万
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财政年份:2014
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负责人:A/Pr Jeremy Thompson
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依托单位:
Characterisation of Cumulus Cell Molecular Mediators of Oocyte Health
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批准号:nhmrc : 1008137
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项目类别:NHMRC Project Grants
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资助金额:$30.13万
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财政年份:2011
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负责人:A/Pr Jeremy Thompson
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依托单位:
Development of engineered novel growth factors for infertility treatment
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批准号:nhmrc : 1017484
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项目类别:NHMRC Development Grants
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资助金额:$27.37万
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财政年份:2011
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负责人:A/Pr Jeremy Thompson
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 627007
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项目类别:NHMRC Research Fellowships
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资助金额:$48.73万
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财政年份:2010
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负责人:A/Pr Jeremy Thompson
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依托单位:
A media formulation to improve implantation rates and pregnancy outcome following ART
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批准号:nhmrc : 519374
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项目类别:NHMRC Development Grants
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资助金额:$20.3万
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财政年份:2008
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负责人:A/Pr Jeremy Thompson
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依托单位:
Exploitation of unique growth factors to develop new products for infertility treatment
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批准号:nhmrc : 453685
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项目类别:NHMRC Development Grants
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资助金额:$8.84万
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财政年份:2007
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负责人:A/Pr Jeremy Thompson
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依托单位:
Periconceptual foundations for a healthy start to life.
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批准号:nhmrc : 453556
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项目类别:Programs
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资助金额:$735.0万
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财政年份:2007
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负责人:A/Pr Jeremy Thompson
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依托单位:
Research Fellowship - Grant ID:349446
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批准号:nhmrc : 349446
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项目类别:NHMRC Research Fellowships
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资助金额:$39.71万
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财政年份:2005
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负责人:A/Pr Jeremy Thompson
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依托单位:
Reproductive health for women
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批准号:nhmrc : 250306
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项目类别:Programs
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资助金额:$449.77万
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财政年份:2003
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负责人:A/Pr Jeremy Thompson
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依托单位:
GM-CSF Regulation of Preimplantation Embryo Development
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批准号:nhmrc : 250388
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项目类别:NHMRC Development Grants
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资助金额:$32.09万
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财政年份:2003
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负责人:A/Pr Jeremy Thompson
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依托单位:
Oxygen, oxidative phosphorylation and regulation of embryo development.
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批准号:nhmrc : 157941
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项目类别:NHMRC Project Grants
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资助金额:$9.41万
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财政年份:2001
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负责人:A/Pr Jeremy Thompson
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依托单位:
海外基金