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Characterisation of Cumulus Cell Molecular Mediators of Oocyte Health

Characterisation of Cumulus Cell Molecular Mediators of Oocyte Health
卵母细胞健康的卵丘细胞分子介质的表征
批准号:
nhmrc : 1008137
负责人:
A/Pr Jeremy Thompson
金额:
$30.13万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

项目摘要

项目成果

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中文摘要
翻译
许多女性生育能力差,因为年龄,疾病和生活方式导致卵子质量差。试管婴儿可以提供帮助,但需要大剂量的激素,这可能导致重大的健康风险。IVM是IVF的替代实验室技术,但成功率很低。我们发现,从最近发现的鸡蛋蛋白质中复制的合成蛋白质可以添加到鸡蛋中,并大大提高IVM的成功率。解释为什么将进一步帮助不孕妇女的治疗
英文摘要
Many women are poorly fertile because of poor egg quality due to age, disease and lifestyle. IVF can assist, but requires large doses of hormone, which can lead to significant health risks. IVM is an alternative lab technique to IVF, but has very poor success. We discovered that synthetic proteins copied from recently discovered egg proteins can be added to the egg and substantially increase IVM success. Answering why will further will aid treatment for infertile women
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New insights into oocyte and embryo health
  • 批准号:
    nhmrc : 1077694
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $52.04万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Jeremy Thompson
  • 依托单位:
Inflammatory cytokines as causal agents in peri-conception programming of offspring health
  • 批准号:
    nhmrc : 1079150
  • 项目类别:
    Project Grants
  • 资助金额:
    $40.28万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Jeremy Thompson
  • 依托单位:
EGF peptide signalling improves oocyte maturation and quality
  • 批准号:
    nhmrc : 1062762
  • 项目类别:
    Project Grants
  • 资助金额:
    $39.13万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Jeremy Thompson
  • 依托单位:
Technology for hormone-free infertility treatment
  • 批准号:
    nhmrc : 1076004
  • 项目类别:
    Development Grants
  • 资助金额:
    $38.1万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Jeremy Thompson
  • 依托单位:
海外基金