Characterisation of Cumulus Cell Molecular Mediators of Oocyte Health

卵母细胞健康的卵丘细胞分子介质的表征

• 批准号: nhmrc : 1008137
• 负责人: A/Pr Jeremy Thompson
• 金额: $ 30.13万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-cumulus-cell-oocyte-health/109284
• 关键词: Characterisation; Cumulus; Cell; Molecular; Mediators

Many women are poorly fertile because of poor egg quality due to age, disease and lifestyle. IVF can assist, but requires large doses of hormone, which can lead to significant health risks. IVM is an alternative lab technique to IVF, but has very poor success. We discovered that synthetic proteins copied from recently discovered egg proteins can be added to the egg and substantially increase IVM success. Answering why will further will aid treatment for infertile women

由于年龄、疾病和生活方式的原因，许多女性的卵子质量不佳，因此生育能力较差。试管受精可以提供帮助，但需要大剂量的激素，这可能会导致重大的健康风险。体外受精是一种替代体外受精的实验室技术，但成功率很低。我们发现，从最近发现的鸡蛋蛋白中复制的合成蛋白质可以添加到鸡蛋中，大大提高体外受精的成功率。回答为什么会进一步有助于不孕不育妇女的治疗